Catalog No.
YHD10901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu271
Predicted molecular weight
31.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P15407
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FRA-1, FRA1, Fos-related antigen 1, FOSL1
Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer., PMID:40414926
Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements., PMID:40399273
FOSL1 promotes keratinocyte migration and wound repair by modulating the IL17 signaling pathway., PMID:40355666
Transcription Factor FOSL1 Promotes Cisplatin Resistance in Non-Small Cell Lung Cancer Cells by Modulating the Wnt3a/β-Catenin Signaling through Upregulation of PLIN3 Expression., PMID:40152390
Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma., PMID:40132584
FOSL1 drives the malignant progression of pancreatic cancer cells by regulating cell stemness, metastasis and multidrug efflux system., PMID:40038751
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition., PMID:39966375
Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis., PMID:39923427
Using the AP1 Transcription Factor FOSL1 to Assess the Exacerbation of Psoriasis., PMID:39835554
FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple-negative breast cancer., PMID:39748430
Spatiotemporal single-cell roadmap of human skin wound healing., PMID:39729995
FAM96B negatively regulates FOSL1 to modulate the osteogenic differentiation and regeneration of periodontal ligament stem cells via ferroptosis., PMID:39696611
Curcumin Alleviates Arecoline-induced Oral Submucous Fibrosis via the FOSL1/MAPK8 Axis., PMID:39674970
Oncogenic KRAS Promotes Ferroptosis in Pancreatic Cancer Through Regulation of the Fosl1-Tfrc Axis., PMID:39626178
Fra-1 affects chemotherapy sensitivity by inhibiting ferroptosis in gastric cancer cells., PMID:39624082
CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression., PMID:39607512
Endothelial FOSL1 drives angiotensin II-induced myocardial injury via AT1R-upregulated MYH9., PMID:39592734
METTL3 and IGF2BP2 coordinately regulate FOSL1 mRNA via m6A modification, suppressing trophoblast invasion and contributing to fetal growth restriction., PMID:39565355
Isorhamnetin ameliorates dopaminergic neuronal damage via targeting FOSL1 to activate AKT/mTOR in 6-OHDA-induced SH-SY5Y cells., PMID:39560297
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer., PMID:39523372
Eravacycline improves the efficacy of anti-PD1 immunotherapy via AP1/CCL5 mediated M1 macrophage polarization in melanoma., PMID:39288620
Saikosaponin A Recovers Impaired Filaggrin Levels in Inflamed Skin by Downregulating the Expression of FRA1 and c-Jun., PMID:39274912
FOSL1 promotes stem cell‑like characteristics and anoikis resistance to facilitate tumorigenesis and metastasis in osteosarcoma by targeting SOX2., PMID:39219279
FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia., PMID:39178842
FOSL1-mediated LINC01566 negatively regulates CD4+ T-cell activation in myasthenia gravis., PMID:39113081
Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation., PMID:39043184
Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cells., PMID:39002513
Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma., PMID:38870013
HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells., PMID:38862832
Interaction of NF-κB and FOSL1 drives glioma stemness., PMID:38856747
FOSL1's Oncogene Roles in Glioma/Glioma Stem Cells and Tumorigenesis: A Comprehensive Review., PMID:38791400
m6A demethylation of FOSL1 mRNA protects hepatoma cells against necrosis under glucose deprivation., PMID:38762597
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury., PMID:38755530
Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc., PMID:38657045
AP-1/C-FOS and AP-1/FRA2 differentially regulate early and late adipogenic differentiation of mesenchymal stem cells., PMID:38440920
Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis., PMID:38402581
FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3., PMID:38367916
Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures., PMID:38325559
Identification and validation of prognostic signature genes of bladder cancer by integrating methylation and transcriptomic analysis., PMID:38172584
miR-497/195 Cluster Affects the Development of Colorectal Cancer by Targeting FRA1., PMID:38147235
Transcription Factor FOSL1 Promotes Angiogenesis of Colon Carcinoma by Regulating the VEGF Pathway Through Activating TIMP1., PMID:38103125
PARP7-mediated ADP-ribosylation of FRA1 promotes cancer cell growth by repressing IRF1- and IRF3-dependent apoptosis., PMID:38011562
Mutant p53 and ELK1 co-drive FRA-1 expression to induce metastasis in breast cancer., PMID:37971884
FOSL1 modulates Schwann cell responses in the wound microenvironment and regulates peripheral nerve regeneration., PMID:37949219
Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression., PMID:37830558
TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness., PMID:37642779
In search of stress: analysis of stress-related markers in mice after hindlimb unloading and social isolation., PMID:37642364
YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells., PMID:37415737
Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells., PMID:37395651
Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis., PMID:37353480
For research use only. Not for human or drug use.
