Catalog No.
YHC42801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala23-Val335
Predicted molecular weight
37.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P09668
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CPSB, Pro-cathepsin H, CTSH
Mendelian randomisation analysis to explore the association between cathepsins and bipolar disorder., PMID:39482620
Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk., PMID:37471639
Cathepsin H: Molecular characteristics and clues to function and mechanism., PMID:37148981
Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer's disease., PMID:36739351
A five-gene methylation signature predicts overall survival of patients with clear cell renal cell carcinoma., PMID:34716619
Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation., PMID:33992646
Some thiocarbamoyl based novel anticathepsin agents., PMID:32932119
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk., PMID:32724101
Characterizing the Causal Pathway for Genetic Variants Associated with Neurological Phenotypes Using Human Brain-Derived Proteome Data., PMID:32413284
Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes., PMID:30146008
Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade., PMID:29470604
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis., PMID:27913303
Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses., PMID:26429317
Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F., PMID:26247631
Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)., PMID:26245339
Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing., PMID:25525168
Molecular and computational analyses of genes involved in mannose 6-phosphate independent trafficking., PMID:25088547
CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients., PMID:24982147
[Changes in active cysteine cathepsins in lysosomes from tissues thyroid papillary carcinomas with various biological characteristics]., PMID:24400560
Amplification of steroid-mediated SP-B expression by physiological levels of caffeine., PMID:24163141
Mutations in LRPAP1 are associated with severe myopia in humans., PMID:23830514
Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus., PMID:23103411
The influence of differential processing of procathepsin H on its aminopeptidase activity, secretion and subcellular localization in human cell lines., PMID:22704610
Genome-wide association study on bipolar disorder in the Bulgarian population., PMID:21771265
Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer., PMID:20731543
[B-, H- and L-cathepsin-like activity in blood plasma of patients with diseases of the thyroid, parathyroid and adrenal glands]., PMID:20684245
The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes., PMID:19732768
Identification, expression and immunolocalization of cathepsin B3, a stage-specific antigen expressed by juvenile Fasciola gigantica., PMID:19632187
Levels of cathepsins S and H in pleural fluids of inflammatory and neoplastic origin., PMID:19404922
[Serum activity of chitotriosidase, lysozyme and cathepsin H in patients with lung cancer and patients with inflammatory exudate (preliminary report)]., PMID:19388531
The interactomics of sortilin: an ancient lysosomal receptor evolving new functions., PMID:19224451
Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer., PMID:18949742
Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis., PMID:18216060
Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1., PMID:17583678
Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis., PMID:17500053
Decrease of cholesterol in mouse melanoma causes secretion of lysosomal enzymes., PMID:17179181
Induced expression of cathepsins and cystatin C in a murine model of demyelination., PMID:17086443
Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide., PMID:17068963
The human cathepsin H gene encodes two novel minor histocompatibility antigen epitopes restricted by HLA-A*3101 and -A*3303., PMID:16822283
Murine M cells express annexin V specifically., PMID:16552796
Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K., PMID:15913550
Acyclic cyanamide-based inhibitors of cathepsin K., PMID:15896958
Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile., PMID:15728581
Serum cathepsin H as a potential prognostic marker in patients with colorectal cancer., PMID:15646835
Use of a transgenic mouse model to identify markers of human lung tumors., PMID:15645424
Some physicochemical properties of cathepsin H from human meningioma., PMID:15627059
Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes., PMID:15196205
Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder., PMID:15183956
Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme., PMID:15127951
Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L., PMID:14767779
For research use only. Not for human or drug use.
