Catalog No.
YHC29301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro297
Predicted molecular weight
34.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07992
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ERCC1, DNA excision repair protein ERCC-1
The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair., PMID:40475541
High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice., PMID:40416846
Targeting Cancer Stem Cells and Hedgehog Pathway: Enhancing Cisplatin Efficacy in Ovarian Cancer With Metformin., PMID:40387464
CARM1/PRMT4 facilitates XPF-ERCC1 heterodimer assembly and maintains nucleotide excision repair activity., PMID:40304182
Targeted inhibition of JMJD2C/MALAT1 axis compensates for the deficiency of metformin in reversing ovarian cancer platinum resistance., PMID:40280301
Excision repair cross complementation group 1 gene exon 3 skipping isoform presents selective cGAS-STING activation in platinum-sensitive lung adenocarcinoma., PMID:40258523
Germline variants in patients from the Iranian hereditary colorectal cancer registry., PMID:40223084
Comprehensive interrogation of synthetic lethality in the DNA damage response., PMID:40205037
Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancers., PMID:40008380
Beyond Nucleotide Excision Repair: The Importance of XPF in Base Excision Repair and Its Impact on Cancer, Inflammation, and Aging., PMID:39769376
Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction., PMID:39753531
Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy., PMID:39735668
The Ercc1-/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration., PMID:39604117
Lung cancer, platinum analog-based frontline treatment and pharmacogenetic limitations., PMID:39560009
m6A-Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma., PMID:39555714
The synergy between alkylating agents and ERCC1-XPF inhibitors is p53 dependent., PMID:39520092
Glioma-astrocyte connexin43 confers temozolomide resistance through activation of the E2F1/ERCC1 axis., PMID:39514365
Association of ERCC1 Gene Polymorphisms (rs3212986 and rs11615) With the Risk of Lung Cancer in a Population From Southeast Iran., PMID:39431656
Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair., PMID:39353945
miR-96-5p expression is sufficient to induce and maintain the senescent cell fate in the absence of stress., PMID:39325426
Calorie restriction increases the sensitivity of progeroid Ercc1Δ/- mice to acute (neuro)inflammation., PMID:39287878
ERCC1 which affects lipids metabolism and actin dynamics in coal workers' pneumoconiosis is a candidate biomarker for early warning and diagnosis., PMID:39283905
Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice., PMID:39245994
Prognostic value of nucleotide excision repair and translesion DNA synthesis proteins in muscle-infiltrating bladder carcinoma., PMID:39237917
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance., PMID:39181133
Potential association of SULT2A1 and ABCG2 variant alleles with increased risk for palbociclib toxicity., PMID:39092502
Does the XPA-FEN1 Interaction Concern to Nucleotide Excision Repair or Beyond?, PMID:39062528
A novel algorithm for the virtual screening of extensive small molecule libraries against ERCC1/XPF protein-protein interaction for the identification of resistance-bypassing potential anticancer molecules., PMID:39051064
The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation., PMID:39003251
Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats., PMID:38977669
KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells., PMID:38926398
Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway., PMID:38924867
Multi-index comprehensive evaluation of the efficacy and response mechanism of immunotherapy in non-small cell lung cancer., PMID:38822977
USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis., PMID:38819674
Pharmacogenomic predictor of long-term residual chemotherapy-induced peripheral neuropathy in ovarian cancer survivors: A substudy of the GINECO Vivrovaire study., PMID:38776631
Prediction of response to promising first-line chemotherapy in ovarian cancer patients with residual peritoneal tumors: practical biomarkers and robust multiplex models., PMID:38767719
Dual‑regulated oncolytic adenovirus carrying ERCC1‑siRNA gene possesses potent antitumor effect on ovarian cancer cells., PMID:38757346
FTO blocks RNA translational activity via the loss of N6-methyladenosine methylation at 5' UTR regulated by RBM5 in cisplatin-resistant NSCLC., PMID:38742685
Formosanin C inhibits pulmonary metastasis by targeting stearyl CoA desaturase-1., PMID:38728921
Prognostic Significance of Excision Repair Cross-Complementation Group 1 on Circulating Tumor Cells for Nasopharyngeal Carcinoma., PMID:38716503
Metabolomic analysis of dietary-restriction-induced attenuation of sarcopenia in prematurely aging DNA repair-deficient mice., PMID:38689513
Gene expression markers in peripheral blood and outcome in patients with platinum-resistant ovarian cancer: A study of the European GANNET53 consortium., PMID:38676430
Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure., PMID:38664429
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines., PMID:38659583
DNA Repair Genetics and the Risk of Radiation Pneumonitis in Patients With Lung Cancer: A Systematic Review and Meta-analysis., PMID:38653664
p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice., PMID:38514641
XPA tumor variant leads to defects in NER that sensitize cells to cisplatin., PMID:38500596
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice., PMID:38498063
Porcine alveolar macrophages host proteins interacting with African swine fever virus p72., PMID:38481793
Relationship between ERCC1 and XPC polymorphisms and the susceptibility to head and neck carcinoma: A systematic review, meta-analysis, and trial sequential analysis., PMID:38479279
For research use only. Not for human or drug use.
