Catalog No.
YHC27601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu180
Predicted molecular weight
21.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07741
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APRT, Adenine phosphoribosyltransferase
2,8-dihyroxyadenine (DHA) crystalline nephropathy: A case report., PMID:40182129
Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single-cell RNA sequencing analysis., PMID:40017120
KBG syndrome: report and follow-up on three unrelated patients observed at different ages., PMID:39985057
Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment., PMID:39844397
CRISPR/Cas9 editing of two adenine phosphoribosyl transferase coding genes reveals the functional specialization of adenine salvage proteins in common bean., PMID:39387692
Multi-omics combined to investigate potential druggable therapeutic targets for stroke: A systematic Mendelian randomization study and transcriptome verification., PMID:39214372
LncR-GAS5 decrease in adenine phosphoribosyltransferase expresssion via binding TAF1 to increase kidney damage created by CIH., PMID:38994083
Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila., PMID:38700995
Targeting with Structural Analogs of Natural Products the Purine Salvage Pathway in Leishmania (Leishmania) infantum by Computer-Aided Drug-Design Approaches., PMID:38393130
Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasma., PMID:38359644
Selection and validation of reliable reference genes for quantitative real-time PCR in Barnyard millet (Echinochloa spp.) under varied abiotic stress conditions., PMID:37731036
Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate., PMID:37321215
Computational multi-target approach to target essential enzymes of Leishmania donovani using comparative molecular dynamic simulations and MMPBSA analysis., PMID:36760044
Cofactor Engineering for Efficient Production of α-Farnesene by Rational Modification of NADPH and ATP Regeneration Pathway in Pichia pastoris., PMID:36675279
[Development of an APRT-deficient CHO cell line and its ability of expressing recombinant protein]., PMID:36151813
miR-10b-5p-mediated upregulation of PIEZO1 predicts poor prognosis and links to purine metabolism in breast cancer., PMID:35351580
Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active., PMID:35104286
Gene Correction of Point Mutations Using PolyPurine Reverse Hoogsteen Hairpins Technology., PMID:34713221
Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme., PMID:34435306
A blueprint for gene function analysis through Base Editing in the model plant Physcomitrium (Physcomitrella) patens., PMID:33421132
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure., PMID:33382739
Inbreeding coefficients and runs of homozygosity islands in Brazilian water buffalo., PMID:33272579
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation., PMID:32939338
Integrated structural and functional analysis of the protective effects of kinetin against oxidative stress in mammalian cellular systems., PMID:32770053
Validation and identification of reference genes in Chinese hamster ovary cells for Fc-fusion protein production., PMID:32216463
The anti-inflammatory function of adenine occurs through AMPK activation and its downstream transcriptional regulation in THP-1 cells., PMID:31392929
Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction., PMID:31160323
Acute kidney failure and discrepant values of urinary proteins: When the case is not "crystal clear"., PMID:30890413
Tamoxifen therapy benefit predictive signature combining with prognostic signature in surgical-only ER-positive breast cancer., PMID:30537139
Examination of Hypoxanthine Guanine Phosphoribosyltransferase as a biomarker for colorectal cancer patients., PMID:30250925
N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation., PMID:29987005
Identification of a DNA Repair-Related Multigene Signature as a Novel Prognostic Predictor of Glioblastoma., PMID:29807183
Crystal structures of APRT from Francisella tularensis - an N-H···N hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases., PMID:29694705
Combining multi-dimensional data to identify a key signature (gene and miRNA) of cisplatin-resistant gastric cancer., PMID:29693274
Microhomology-assisted scarless genome editing in human iPSCs., PMID:29507284
Selection and validation of reference genes for RT-qPCR analysis in potato under abiotic stress., PMID:29075311
Schistosoma mansoni purine and pyrimidine biosynthesis: structures and kinetic experiments in the search for the best therapeutic target., PMID:29022512
Application of droplet digital PCR to determine copy number of endogenous genes and transgenes in sugarcane., PMID:28849385
Schistosoma mansoni displays an adenine phosphoribosyltransferase preferentially expressed in mature female gonads and vitelaria., PMID:28392476
The biosynthetic pathway of 2-azahypoxanthine in fairy-ring forming fungus., PMID:27991529
The homologous recombination protein RAD51D protects the genome from large deletions., PMID:27924006
Evolutionary engineering of Geobacillus thermoglucosidasius for improved ethanol production., PMID:27002479
Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells., PMID:26544976
Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals., PMID:26455426
Adenine phosphoribosyltransferase from Sulfolobus solfataricus is an enzyme with unusual kinetic properties and a crystal structure that suggests it evolved from a 6-oxopurine phosphoribosyltransferase., PMID:25790177
Deregulation of purine metabolism in Alzheimer's disease., PMID:25311278
Protective effects of ascorbic acid against the genetic and epigenetic alterations induced by 3,5-dimethylaminophenol in AA8 cells., PMID:25178734
Adenine phosphoribosyltransferase (APRT) deficiency: identification of a novel nonsense mutation., PMID:24986359
Selection of suitable endogenous reference genes for relative copy number detection in sugarcane., PMID:24857916
Investigation of adipocyte proteome during the differentiation of brown preadipocytes., PMID:24129212
For research use only. Not for human or drug use.
