Catalog No.
YHC25401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp339
Predicted molecular weight
40.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07355
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lipocortin II, Annexin A2, Calpactin-1 heavy chain, PAP-IV, p36, CAL1H, Calpactin I heavy chain, ANX2, ANX2L4, Protein I, Annexin-2, LPC2D, Annexin II, ANXA2, Placental anticoagulant protein IV, Chromobindin-8
Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma., PMID:40496929
Proteomic profiling of the human amniotic stem cell-highly abundant secreted proteins., PMID:40487068
S100 A16 promotes the progression of osteosarcoma by activating the PI3 K/AKT signaling pathway through ANXA2., PMID:40481236
TAGLN2 Exacerbates Acute Pancreatitis-Induced Liver Injury by Increasing Hepatocyte Pyroptosis via Kupffer Cells-Mediated Inflammatory Response., PMID:40472315
Transcriptome and proteome profile analysis of the regulation of chicken ovarian development., PMID:40466268
The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2., PMID:40369630
HSPB1/KDM1 A facilitates ANXA2 expression via hypomethylated DNA promoter to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer., PMID:40366396
Annexin A2 Contributes to Release of Extracellular Vimentin in Response to Inflammation., PMID:40346842
ANXA2 regulates mitochondrial function and cellular senescence of PDLCs via AKT/eNOS signaling pathway under high glucose conditions., PMID:40328825
Target Identification of Ginsenosides Against Cognitive Impairment by Using Mass Spectrometry-Based Cellular Thermal Shift Assay (CETSA)., PMID:40323441
Exosome biomarkers in breast cancer: Systematic review and meta-analysis., PMID:40311726
The relevance of calcium-binding domains to promoting activities of annexin A2 in calcium oxalate stone formation., PMID:40280516
AnxA2-EGFR pro-inflammatory signaling potentiates EMT-induced fibrotic stress and its modulation by short-chain fatty acid butyrate in idiopathic pulmonary fibrosis., PMID:40239744
ANXA2 in cancer: aberrant regulation of tumour cell apoptosis and its immune interactions., PMID:40234383
E53, E96, D162, E247 and D322 in Ca2+-binding domains of annexin A2 are essential for regulating intracellular [Ca2+] and crystal adhesion to renal cells via ERK1/2 and JNK signaling pathways., PMID:40189002
Lactylation-driven USP4-mediated ANXA2 stabilization and activation promotes maintenance and radioresistance of glioblastoma stem cells., PMID:40185997
Multi-Omic Analysis Reveals Astrocytic Annexin-A2 as Critical for Network-Level Circadian Timekeeping in the Suprachiasmatic Nucleus., PMID:40171808
PD-L1/PD-1 checkpoint pathway regulates astrocyte morphogenesis and myelination during brain development., PMID:40164696
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation., PMID:40164417
ANXA2 Protein and Its Role in Neurodegeneration Processes., PMID:40141747
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer., PMID:40138122
[The application of ANXA2 gene knockout mouse models in lung cancer metastasis]., PMID:40113426
Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients., PMID:40112136
A Pilot Study of ANXA2, MED12, CALM1 and MAPK1 Gene Variants in Primary Hyperparathyroidism., PMID:40070855
USP10/XAB2/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancer., PMID:40069750
Identification and validation of a CD4+ T cell-related prognostic model to predict immune responses in stage III-IV colorectal cancer., PMID:40069612
Annexin A's Life in Pan-Cancer: Especially in Glioma Immune Cells., PMID:40011350
miRNome analysis reveals mir-155-5p as a protective factor to dengue infection in a resistant Thai cohort., PMID:39976655
MMP28 recruits M2-type tumor-associated macrophages through MAPK/JNK signaling pathway-dependent cytokine secretion to promote the malignant progression of pancreatic cancer., PMID:39972459
LncRNA-MEG3 Mediated Diabetic Cerebral Ischemia-Reperfusion Injury-Induced Apoptosis via Modulating Interaction Between Annexin A2 and Akt in Mitochondria., PMID:39912333
The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review., PMID:39892077
Confined CHA-HCR system for sensitive and specific detection of ANXA2 mRNA in adenomyosis tissues., PMID:39879821
Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo., PMID:39867883
A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis., PMID:39865116
ANXA2 promotes chondrocyte differentiation and fracture healing by regulating the phosphorylation of STAT3 and PI3K/AKT signaling pathways., PMID:39863030
Mechanistic insights into HPV-positivity in non-smokers and HPV-negativity in smokers with head and neck cancer., PMID:39850816
Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis., PMID:39833358
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line., PMID:39733438
DHAV-1 3C protein promotes viral proliferation by antagonizing type I interferon via upregulating the ANXA2 protein., PMID:39722380
Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2., PMID:39709496
Bone metastasis in endocrine-related cancer: unravelling invasion and destruction., PMID:39699130
Biomarkers and potential therapeutic targets driving progression of non-alcoholic steatohepatitis to hepatocellular carcinoma predicted through transcriptomic analysis., PMID:39697329
Annexin A2: the feasibility of being a therapeutic target associated with cancer metastasis and drug resistance in cancer microenvironment., PMID:39692932
Phosphorylation of annexin A2 at serine 25 is required for endothelin-1 stimulated cell proliferation and AKT activation in melanoma cells., PMID:39675170
Differential structural characteristics, physicochemical properties, and calcium-binding capabilities of annexin A2 wild-type versus E53A, E96A, D162A, E247A and D322A mutants., PMID:39674566
Heterologous expression, purification and generation of specific antibodies for Annexin A8., PMID:39674528
Annexin A2 in Tumors of the Gastrointestinal Tract, Liver, and Pancreas., PMID:39594718
Visium spatial transcriptomics and proteomics identifies novel hepatic cell populations and transcriptomic signatures of alcohol-associated hepatitis., PMID:39592394
Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling., PMID:39572752
Annexin levels in GCF determine the imbalance of periodontal inflammatory regulation., PMID:39572681
For research use only. Not for human or drug use.
