Catalog No.
YHC15501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr239
Predicted molecular weight
29.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05198
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EIF2A, eIF-2A, Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit 1, EIF2S1, eIF-2-alpha, eIF-2alpha
EIF2S1 in Urinary Extracellular Vesicles as a Novel Diagnostic Marker for Bladder Cancer., PMID:40365898
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition., PMID:40304759
Plasticity of the mammalian integrated stress response., PMID:40140574
Calcium release from damaged lysosomes triggers stress granule formation for cell survival., PMID:39962896
Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseases., PMID:39920481
Identification of fibrosis-associated lncRNAs in diabetic cardiomyopathy patients., PMID:39475132
Isovalerylspiramycin I suppresses small cell lung cancer proliferation via ATR/CHK1 mediated DNA damage response and PERK/eIF2α/ATF4/CHOP mediated ER stress., PMID:39353535
Changes in the liver proteome of zebrafish (Danio rerio) exposed to glyphosate and aminomethylphosphonic acid in the presence of a humic substance., PMID:39277363
Identification of Biomarkers Associated With Paget's Disease of Bone and Bone Metastasis From Breast Cancer Patients., PMID:39233667
Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis., PMID:39103048
Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha-synuclein levels in Lewy body disease., PMID:39036837
Identification of differentially expressed ER stress-related genes and their association with pulmonary arterial hypertension., PMID:38789967
Suppression of PERK/eIF2α/CHOP pathway enhances oridonin-induced apoptosis by inhibiting autophagy in Small-Cell lung cancer cells., PMID:38713951
Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury., PMID:38539069
EIF2Ss, a Novel c-Myc-Correlated Gene Family, is Associated with Poor Prognosis and Immune Infiltration in Pancreatic Adenocarcinoma., PMID:38538250
Heparanase interacting BCLAF1 to promote the development and drug resistance of ICC through the PERK/eIF2α pathway., PMID:38467765
Adipose mesenchymal stem cell-derived exosomes promote skin wound healing in diabetic mice by regulating epidermal autophagy., PMID:38434722
Tris(1,3-dichloro-2-propyl) phosphate induces endoplasmic reticulum stress and mitochondrial-dependent apoptosis in mouse spermatocyte GC-2 cells., PMID:38331085
Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches., PMID:38322303
CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5., PMID:38272235
MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage., PMID:38151653
Ochratoxin A triggers endoplasmic reticulum stress through PERK/NRF2 signaling and DNA damage during early embryonic developmental competence in pigs., PMID:38064788
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice., PMID:37828427
Identification of hub genes and potential inhibitory compounds in the process of liver transplantation through transcriptome sequencing., PMID:37802426
Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting., PMID:37581984
Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock., PMID:37379316
Nutrient-dependent regulation of β-cell proinsulin content., PMID:37209827
MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma: A Systems Biology Approach., PMID:37143570
RNA-Sequencing Characterization of lncRNA and mRNA Functions in Septic Pig Liver Injury., PMID:37107704
Identification of a m6A-related ferroptosis signature as a potential predictive biomarker for lung adenocarcinoma., PMID:37072786
Bioinformatics Analysis of Molecular Interactions between Endoplasmic Reticulum Stress and Ferroptosis under Stress Exposure., PMID:37035018
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice., PMID:36934083
Autophagy is induced by swine acute diarrhea syndrome coronavirus through the cellular IRE1-JNK-Beclin 1 signaling pathway after an interaction of viral membrane-associated papain-like protease and GRP78., PMID:36888569
Establishment of Ferroptosis-Related Key Gene Signature and Its Validation in Compression-Induced Intervertebral Disc Degeneration Rats., PMID:36819777
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress., PMID:36719671
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response., PMID:36596357
PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells., PMID:36555509
Hub Genes in Non-Small Cell Lung Cancer Regulatory Networks., PMID:36551208
Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair., PMID:36430812
Analgesic Effectiveness and Dorsal Root Ganglia Protein Modulation of a Peripheral Adenosine Monophosphate Kinase Alpha Activator (O304) Following Lumbar Disk Puncture in the Mouse., PMID:36201356
Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation., PMID:35857873
Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells., PMID:35803572
ERH Interacts With EIF2α and Regulates the EIF2α/ATF4/CHOP Pathway in Bladder Cancer Cells., PMID:35774124
Glucocorticoids enhance chemotherapy-driven stress granule assembly and impair granule dynamics, leading to cell death., PMID:35713120
Clustering analysis revealed the autophagy classification and potential autophagy regulators' sensitivity of pancreatic cancer based on multi-omics data., PMID:35684936
Melatonin Induces AGS Gastric Cancer Cell Apoptosis via Regulating PERK/eIF2α and HSF1/NF-κB Signaling Pathway., PMID:35181617
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer., PMID:35163244
LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1., PMID:35095099
A Starvation-Based 9-mRNA Signature Correlates With Prognosis in Patients With Hepatocellular Carcinoma., PMID:34900672
Substrate recognition determinants of human eIF2α phosphatases., PMID:34847777
For research use only. Not for human or drug use.
