Catalog No.
YHC13701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys14-Asp100
Predicted molecular weight
11.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05114
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HMG14, Non-histone chromosomal protein HMG-14, HMGN1, High mobility group nucleosome-binding domain-containing protein 1
HMGB1 as a biomarker for myeloproliferative neoplasm complicated with atherosclerosis., PMID:40383792
Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1., PMID:40272371
CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study., PMID:39897524
HMGA2 as a prognostic and immune biomarker in hepatocellular carcinoma: Comprehensive analysis of the HMG family and experiments validation., PMID:39591457
Phosphorylation of the HMGN1 Nucleosome Binding Domain Decreases Helicity and Interactions with the Acidic Patch., PMID:39186607
HMGN1 loss sensitizes lung cancer cells to chemotherapy., PMID:38710740
KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer's disease., PMID:38617985
Combinational delivery of TLR4 and TLR7/8 agonist enhanced the therapeutic efficacy of immune checkpoint inhibitors to colon tumor., PMID:38507020
Do Alarmins Have a Role in Multiple Myeloma?, PMID:38426298
HMGN1 down-regulation in the diabetic kidney attenuates tubular cells injury and protects against renal inflammation via suppressing MCP-1 and KIM-1 expression through TLR4., PMID:38409569
Pan-cancer Multi-omics Analysis Reveals HMGN1 as a Potential Prognostic and Immune Infiltration-associated Biomarker., PMID:38310387
[High mobility group nucleosome binding protein 1 (HMGN1) induces activation of mouse BV2 microglia and upregulates their pro-inflammatory mediator expression by activating TLR4/MyD88/NF-κB p65/IKK-β signal pathway]., PMID:38284254
Chromatin binding protein HMGN1 promotes HBV cccDNA transcription and replication by regulating the phosphorylation of histone 3., PMID:38181856
Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins., PMID:37950483
Reactive Oxygen Species-Sensitive Biodegradable Mesoporous Silica Nanoparticles Harboring TheraVac Elicit Tumor-Specific Immunity for Colon Tumor Treatment., PMID:37831945
PM2.5 exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice., PMID:37671359
Gain of chromosome 21 increases the propensity for P2RY8::CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression., PMID:37483494
The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21., PMID:37216686
linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells., PMID:37191016
Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies., PMID:37190294
HMGN1 enhances CRISPR-directed dual-function A-to-G and C-to-G base editing., PMID:37105976
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome., PMID:36995257
Anti-TNFR2 enhanced the antitumor activity of a new HMGN1/3M-052 stimulated dendritic cell vaccine in a mouse model of colon cancer., PMID:36868074
Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway., PMID:36691481
Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer., PMID:36568211
Eugenol attenuates ischemia-mediated oxidative stress in cardiomyocytes via acetylation of histone at H3K27., PMID:36526244
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain., PMID:36463299
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins., PMID:36435799
An immunogenic cell death-related regulators classification patterns and immune microenvironment infiltration characterization in intracranial aneurysm based on machine learning., PMID:36248807
Tumor-Infiltrated CD8+ T Cell 10-Gene Signature Related to Clear Cell Renal Cell Carcinoma Prognosis., PMID:35812454
HMGN4 plays a key role in STAT3-mediated oncogenesis of triple-negative breast cancer., PMID:35792800
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin., PMID:35761366
Correlation Between Plasma High Mobility Group Protein N1 Level and the Prognosis of Patients with Acute Cerebral Infarction: Preliminary Findings., PMID:35469241
H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors., PMID:35197580
Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome., PMID:34946949
HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort., PMID:34857887
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer., PMID:34794079
Function of chromatin modifier Hmgn1 during neural crest and craniofacial development., PMID:34478234
Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications., PMID:34458797
Combining an Alarmin HMGN1 Peptide with PD-L1 Blockade Results in Robust Antitumor Effects with a Concomitant Increase of Stem-Like/Progenitor Exhausted CD8+ T Cells., PMID:34344641
Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters., PMID:34335698
Characterization of Novel Progression Factors in Castration-Resistant Prostate Cancer Based on Global Comparative Proteome Analysis., PMID:34298646
Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity., PMID:34118309
Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells., PMID:33597549
Prognostic value of HMGN family expression in acute myeloid leukemia., PMID:33467898
Identification of Tumorigenic and Prognostic Biomarkers in Colorectal Cancer Based on microRNA Expression Profiles., PMID:32802869
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice., PMID:32286296
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity., PMID:32179749
Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair., PMID:32152397
FAM96B inhibits the senescence of dental pulp stem cells., PMID:32039527
For research use only. Not for human or drug use.
