Catalog No.
YHC15001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu309-His534
Predicted molecular weight
27.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05166
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PCCase subunit beta, PCCB, Propanoyl-CoA:carbon dioxide ligase subunit beta, Propionyl-CoA carboxylase beta chain, mitochondrial
CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progression., PMID:40306957
LILRB1-directed CAR-T cells for the treatment of hematological malignancies., PMID:40186066
RNA-sequencing: A reliable tool to unveil transcriptional landscape of paediatric B-other acute lymphoblastic leukaemia., PMID:40159352
The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies., PMID:40093096
Six Chinese patients with propionic acidemia: from asymptomatic to death in the neonatal period., PMID:40075390
Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model., PMID:40067762
Novel CRISPR-Cas9 iPSC knockouts for PCCA and PCCB genes: advancing propionic acidemia research., PMID:40044943
Role of procalcitonin, C-reactive protein and ferritin in cytokine release syndrome after CAR T-cell therapy in children and young adults., PMID:39817702
A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro., PMID:39714446
Propionic Acidemia diagnosed in Amish adults and pregnancy outcomes: A case series., PMID:39639993
Causal gene identification using mitochondria-associated genome-wide mendelian randomization in atrial fibrillation., PMID:39135799
Human EWS-FLI protein levels and neomorphic functions show a complex, function-specific dose-response relationship in Drosophila., PMID:39013417
Dissecting genetic architecture of rare dystonia: genetic, molecular and clinical insights., PMID:38458754
Establishment of a non-integrated iPSC line (SDQLCHi043-A) from a male infant with propionic acidemia carrying compound heterozygote mutations in PCCB gene., PMID:38394970
Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring., PMID:38292483
Regulating PCCA gene expression by modulation of pseudoexon splicing patterns to rescue enzyme activity in propionic acidemia., PMID:38204914
Inotuzumab ozogamicin combined with chemotherapy in pediatric B-cell precursor CD22+ acute lymphoblastic leukemia: results of the phase IB ITCC-059 trial., PMID:38186333
Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease., PMID:37988184
Functional analysis of novel variants identified in cis in the PCCB gene in a patient with propionic acidemia., PMID:37839763
Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility., PMID:37670049
Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways., PMID:37620341
Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis., PMID:36714878
Natural history of propionic acidemia in the Amish population., PMID:36393899
[Differential diagnosis of a Chinese pedigree with methylmalonic acidemia by next-generation sequencing]., PMID:35810423
MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment., PMID:35715791
MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment., PMID:35393436
Identification of epilepsy concomitant candidate genes recognized in Saudi epileptic patients., PMID:35363364
Nucleic Acid-Based COVID-19 Therapy Targeting Cytokine Storms: Strategies to Quell the Storm., PMID:35330388
Therapeutic potential of living donor liver transplantation from heterozygous carrier donors in children with propionic acidemia., PMID:35189944
Combination of atmospheric and room temperature plasma (ARTP) mutagenesis, genome shuffling and dimethyl sulfoxide (DMSO) feeding to improve FK506 production in Streptomyces tsukubaensis., PMID:34160747
Functional Analysis of the PCCA and PCCB Gene Variants Predicted to Affect Splicing., PMID:33923806
Novel variants of the PCCB gene in Chinese patients with propionic acidemia., PMID:33798502
Gene diagnosis and pedigree analysis of two Han ethnicity families with propionic acidemia in Fujian., PMID:33725819
Cardiomyocytes Derived from Induced Pluripotent Stem Cells as a Disease Model for Propionic Acidemia., PMID:33503868
Functional Common and Rare ERBB2 Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility., PMID:33419763
Propionic acidemia identified in twin siblings conceived by in vitro fertilization (IVF) with parents who were unknown carriers of a PCCA mutation., PMID:33183246
Biochemical phenotype and its relationship to treatment in 16 individuals with PCCB c.1606A > G (p.Asn536Asp) variant propionic acidemia., PMID:33127324
RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis., PMID:33097530
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia., PMID:33087718
Characterization and directed evolution of propionyl-CoA carboxylase and its application in succinate biosynthetic pathway with two CO2 fixation reactions., PMID:32860966
Generation of isogenic Propionyl-CoA carboxylase beta subunit (PCCB) deficient induced pluripotent stem cell lines., PMID:32822967
DNA Methylation Associated with Mitochondrial Dysfunction in a South African Autism Spectrum Disorder Cohort., PMID:32490597
Case reports: three novel variants in PCCA and PCCB genes in Chinese patients with propionic acidemia., PMID:32252659
Functional characterisation of fatty acyl desaturase, Fads2, and elongase, Elovl5, in the Boddart's goggle-eyed goby Boleophthalmus boddarti (Gobiidae) suggests an incapacity for long-chain polyunsaturated fatty acid biosynthesis., PMID:32222967
Clinical features of 27 Turkish Propionic acidemia patients with 12 novel mutations., PMID:31916709
WT1-Mutant Wilms Tumor Progression Is Associated With Diverting Clonal Mutations of CTNNB1., PMID:31876779
Crystal structure of a neoagarobiose-producing GH16 family β-agarase from Persicobacter sp. CCB-QB2., PMID:31784792
Generation and characterization of a human iPSC line (UAMi004-A) from a patient with propionic acidemia due to defects in the PCCB gene., PMID:31132581
Identification of 34 novel mutations in propionic acidemia: Functional characterization of missense variants and phenotype associations., PMID:30274917
For research use only. Not for human or drug use.
