InVivoMAb Anti-Human LGR5/GPR49 (Iv0101)

Catalog No.

VHB21801

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, LGR5, GPR49, GPR67

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O75473

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0101

Insights from the bottom-up development of LGR5-targeting immunotherapeutics., PMID:40405910

Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy., PMID:40398537

In vitro anti-tumor activities of a novel recombinant immunotoxin targeting differentially overexpressed Leucine-rich repeat-containing G-protein-coupled receptor 5 in cervical cancer., PMID:40376858

LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer., PMID:40280884

Development of Sheep Duodenum Intestinal Organoids and Implementation of High-Throughput Screening Platform for Veterinary Applications., PMID:40244396

Abortive PDCoV infection triggers Wnt/β-catenin pathway activation, enhancing intestinal stem cell self-renewal and promoting chicken resistance., PMID:40135895

FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development., PMID:40102860

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea., PMID:40091489

The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells., PMID:39952238

Necrotizing enterocolitis causes increased ileal goblet cell loss in Wnt2b KO mice., PMID:39829885

Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis., PMID:39764876

Apical-out intestinal organoids as an alternative model for evaluating deoxynivalenol toxicity and Lactobacillus detoxification in bovine., PMID:39733018

Conditional Overexpression of Net1 Enhances the Trans-Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea., PMID:39675772

Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation., PMID:39634560

Glial cell line derived neurotrophic factor (GDNF) induces mucosal healing via intestinal stem cell niche activation., PMID:39610047

Gpr54 deletion accelerates hair cycle and hair regeneration., PMID:39587329

FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response., PMID:39579768

Limosilactobacillus reuteri B1/1 modulated the intestinal immune response in preventing Salmonella Enteritidis PT4 infection in a chicken ileal explant model., PMID:39579331

Utilizing the apical-out enteroids in vitro model to investigate intestinal glucose transport, barrier function, oxidative stress, and inflammatory responses in broiler chickens., PMID:39568543

ISL1 and AQP5 complement each other to enhance gastric cancer cell stemness by regulating CD44 expression., PMID:39525012

Lgr5 + intestinal stem cells are required for organoid survival after genotoxic injury., PMID:39503201

Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells., PMID:39485528

Cooperation of Wnt/β-catenin and Dll1-mediated Notch pathway in Lgr5-positive intestinal stem cells regulates the mucosal injury and repair in DSS-induced colitis mice model., PMID:39444950

RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells., PMID:39432578

Macrophage-Derived Exosomes Promoted the Development and Stemness of Inflammatory Bowel Disease-Related Colorectal Cancer via nuclear paraspeckle assembly transcript 1-Mediated miRNA-34a-5p/phosphoprotein enriched in astrocytes 15 Axis., PMID:39425913

Vasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury., PMID:39380035

A live single-cell reporter system reveals drug-induced plasticity of a cancer stem cell-like population in cholangiocarcinoma., PMID:39349745

Extrahepatic Bile Duct Organoids as a Model to Study Ischemia/Reperfusion Injury During Liver Transplantation., PMID:39323909

1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5+ Intestinal Stem Cells In Vitro and In Vivo., PMID:39273035

4-Hydroxynonenal Promotes Colorectal Cancer Progression Through Regulating Cancer Stem Cell Fate., PMID:39264845

Inflammation-induced epigenetic imprinting regulates intestinal stem cells., PMID:39232559

Enhanced In Vitro Recapitulation of In Vivo Liver Regeneration by Co-Culturing Hepatocyte Organoids with Adipose-Derived Mesenchymal Stem Cells, Alleviating Steatosis and Apoptosis in Acute Alcoholic Liver Injury., PMID:39120332

Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma., PMID:39065640

QPH-FR: A Novel Quinoa Peptide Enhances Chemosensitivity by Targeting Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Colorectal Cancer., PMID:39047262

Reassessing the genetic lineage tracing of lingual Lgr5+ and Lgr6+ cells in vivo., PMID:39040684

The differentiation of Lgr5+ progenitor cells on nanostructures of self-assembled silica beads., PMID:38995923

WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors., PMID:38971196

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition., PMID:38915718

Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury., PMID:38848678

Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation., PMID:38815584

The main duct of von Ebner's glands is a source of Sox10 + taste bud progenitors and susceptible to pathogen infections., PMID:38798668

Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury., PMID:38645040

SOX17 enables immune evasion of early colorectal adenomas and cancers., PMID:38418875

LGR5 as a Therapeutic Target of Antibody-Functionalized Biomimetic Magnetoliposomes for Colon Cancer Therapy., PMID:38414530

Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo., PMID:38335653

CDKN2A-p16 Deletion and Activated KRASG12D Drive Barrett's-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions., PMID:38296052

Direct Reprogramming of Hepatocytes Into JAK/Stat-Dependent LGR5+ Liver Cells Able to Initiate Intrahepatic Cholangiocarcinoma., PMID:38262709

Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells., PMID:38243680

NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations., PMID:38228611

Adult stem cell activity in naked mole rats for long-term tissue maintenance., PMID:38123565

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