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Anti-Human CA72-4/TAG72 Antibody (B72.3)

Catalog #:   RHK10001 Specific References (149) DATASHEET
Host species: Mouse
Isotype: IgG1, kappa
Applications: ELISA, FCM, IP, RIA, WB
Accession: TAG-72
Overview

Catalog No.

RHK10001

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

TAG-72, TAG72, HMW mucin-like glycoprotein, Cancer antigen 72-4, CA 72-4, CA 72-4/TAG72,STn,TAG-72

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

TAG-72

Applications

ELISA, FCM, IP, RIA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

B72.3

Data Image
References

[CA72-4 (TAG72)]. PMID: 10778173

[CA72 -4 (TAG72)]. PMID: 20963906

[CA72-4 (TAG-72)]. PMID: 16149608

Serum and tissue measurements of CA72-4 in ovarian cancer patients. PMID: 8381375

[Histological localization of TAG72 in gastric cancers and a clinico-pathological study of the CA72-4 serum values]. PMID: 2161468

T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope. PMID: 9322511

[Borderline Ovarian Tumours: CNGOF Guidelines for Clinical Practice - Value of Tumor Markers]. PMID: 32004789

Activation of resting T cells against the CA 72-4 tumor antigen with an anti-CD3/CA 72-4 bispecific antibody in combination with a costimulatory anti-CD28 antibody. PMID: 9216660

[Immunologically defined tumor-associated antigens: the possibilities and limitations of their use in gastroenterology]. PMID: 3061930

[Levels of circulating tumor-associated glycoprotein (TAG-72) in patients with carcinoma using a novel tumor marker, CA 72-4]. PMID: 3166366

Comparison of serum assays for TAG-72, CA19-9 and CEA in gastrointestinal carcinoma patients. PMID: 2810823

Technical performance of the Elecsys CA 72-4 test--development and field study. PMID: 11326700

Clinical evaluation of serum tumor-associated glycoprotein-72 as a novel tumor marker for colorectal cancer patients. PMID: 1892526

Apocrine carcinoma, adenopathies, and raised TAG-72 serum tumor marker. PMID: 15056154

[Fundamental studies and the reference values of cancer associated antigen TAG-72 (CA72-4)]. PMID: 3246730

The use of monoclonal antibody B72.3 in the management of gynecologic malignancies. PMID: 3055701

Tumor targeting with monoclonal antibody B72.3. PMID: 2654088

Binding of radiolabeled MAb B72.3 administered intravenously and intraperitoneally in colorectal cancer patients. An overview. PMID: 1966958

Applications of monoclonal antibodies in clinical cytology as exemplified by studies with monoclonal antibody B72.3. The George N. Papanicolaou award lecture. PMID: 3314301

Chimeric B72.3 mouse/human (IgG1) antibody directs the lysis of tumor cells by lymphokine-activated killer cells. PMID: 2386980

Utility of Claudin-4 versus BerEP4 and B72.3 in pleural fluids with metastatic lung adenocarcinoma. PMID: 32184064

Reactivity of B72.3 with adenocarcinomas. An immunohistochemical study of 476 cases. PMID: 8402466

90Y.B72.3 against pancreatic cancer: dosimetric and biological analysis. PMID: 2211210

Tumor targeting with monoclonal antibody B72.3: experimental and clinical results. PMID: 1977453

Generation and characterization of monoclonal antibody B72.3. Experimental and preclinical studies. PMID: 1576348

111In-(1-isothiocyanatobenzyl-3-methyldiethylenetriaminepentaaetic acid)-anti–TAG-72 humanized CH2 domain-deleted antibody. PMID: 20641320

Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen. PMID: 3396010

Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast. PMID: 17004974

A B72.3 second-generation-monoclonal antibody (CC49) defines the mucin-carried carbohydrate epitope Gal beta(1-3) [NeuAc alpha(2-6)]GalNAc. PMID: 2469434

Production of a bifunctional hybrid molecule B72.3/metallothionein-1 by protein engineering. PMID: 8495976

Pretargeting CWR22 prostate tumor in mice with MORF-B72.3 antibody and radiolabeled cMORF. PMID: 17909792

B72.3 and CD34 immunoreactivity in malignant epithelioid soft tissue tumors. Adjuncts in the recognition of endothelial neoplasms. PMID: 7678485

The value of monoclonal antibody B72.3 for the diagnosis of breast carcinoma: experience with the first commercially available source. PMID: 1864590

The utility of B72.3, carcinoembryonic antigen, and Leu M-1 in cell blocks: an adjunct to fine-needle aspiration diagnosis of bronchioloalveolar carcinoma of the lung. PMID: 15971208

B72.3 immunoreactivity in benign abdominal lymph nodes associated with gastrointestinal disease. PMID: 7656749

Efficacy of monoclonal antibody 131I-B72.3 immunoscintigraphy of pancreatic adenocarcinoma xenografts in nude mice. PMID: 10452260

Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3. PMID: 17591549

Monoclonal antibody B72.3 reactivity with human endometrium: a study of normal and malignant tissues. PMID: 3429107

Monoclonal antibody B72.3 in benign breast lesions. PMID: 2266175

Purification of recombinant chimeric B72.3 Fab' and F(ab')2 using streptococcal protein G. PMID: 1458050

Human biodistribution of 111In-labeled B72.3 monoclonal antibody. PMID: 2297744

Radioimmunoscintigraphy of colon cancer with iodine-131-labeled B72.3 monoclonal antibody. PMID: 3373312

Re-188 labelled antibodies. PMID: 8589673

Immunohistochemistry with monoclonal antibody B72.3 as an adjunct in the cytologic diagnosis of pancreatic carcinoma. PMID: 2467286

Detection of primary colorectal cancer with indium 111 monoclonal antibody B72.3. PMID: 2244814

Pharmacokinetics of 99mTc-metallothionein-B72.3 and its F(ab')2 fragment. PMID: 2297730

Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72.3. PMID: 2924317

Use of a monoclonal antibody (B72.3) as an immunocytochemical adjunct to diagnosis of adenocarcinoma in human effusions. PMID: 3884146

Expression, purification and characterization of B72.3 Fv fragments. PMID: 8457200

Cytomorphology and B72.3 labeling of benign and malignant ductal epithelium in pancreatic lesions compared to gastrointestinal epithelium. PMID: 17427224

Reactivity of CO17-1A and B72.3 in benign and malignant pancreatic diseases. PMID: 2673979

Immunoperoxidase studies by monoclonal antibody B72.3 applied to breast aspirates: diagnostic considerations. PMID: 3072171

Indium-111-labeled B72.3 monoclonal antibody in the detection and staging of breast cancer: a phase I study. PMID: 2066785

Differences in biodistribution of indium-111-and iodine-131-labeled B72.3 monoclonal antibodies in patients with colorectal cancer. PMID: 2738661

Clinical pharmacology, metabolism, and tissue distribution of 90Y-labeled monoclonal antibody B72.3 after intraperitoneal administration. PMID: 1721093

[Anti-sTn antibody 3P9 and B72.3 in serological diagnosis of endometrial carcinoma]. PMID: 24316923

Reactivity of the monoclonal antibody B72.3 with fetal antigen: correlation with expression of TAG-72 in human carcinomas. PMID: 3048576

Enhanced tumor binding using immunohistochemical analyses by second generation anti-tumor-associated glycoprotein 72 monoclonal antibodies versus monoclonal antibody B72.3 in human tissue. PMID: 2297774

Expression of human tumor mucin-associated carbohydrate epitopes, including sialylated Tn, and localization of murine monoclonal antibodies CC49 and B72.3 in a syngeneic rat colon carcinoma model. PMID: 7533599

Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72.3 in athymic mice bearing human colon carcinoma xenografts. PMID: 2785585

A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations. PMID: 6284656

Immunoreactivity of canine epithelial and nonepithelial neoplasms with monoclonal antibody B72.3. PMID: 7771055

Monoclonal antibody B72.3 reacts with a core region structure of O-linked carbohydrates. PMID: 3399812

Complementation of intracavitary and intravenous administration of a monoclonal antibody (B72.3) in patients with carcinoma. PMID: 3607761

Polarization in RMnO3 multiferroics. PMID: 26830791

Monoclonal antibody B72.3 immunostaining of breast carcinoma. Patterns of staining and relationship to mucin content and GCDFP-15 reactivity. PMID: 1370877

Applications of immunocytochemistry to clinical cytology. PMID: 3327572

Tumor-associated glycoprotein expression in salivary gland mucoepidermoid carcinomas: an immunohistochemical study using the monoclonal antibody B72.3. PMID: 8127187

Radioimmunoscintigraphy of human colon cancer xenografts in mice with radioiodinated monoclonal antibody B72.3. PMID: 6333494

Comparison of methods for the generation of immunoreactive fragments of a monoclonal antibody (B72.3) reactive with human carcinomas. PMID: 2499638

A tumor-associated antigen in carcinoma of the pancreas defined by monoclonal antibody B72.3. PMID: 3277379

Tumor-associated glycoprotein (TAG-72) in ovarian carcinomas defined by monoclonal antibody B72.3. PMID: 3520078

Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. PMID: 3652889

Radioiodinated anti–TAG-72 CC49 Fab’ antibody fragment. PMID: 20641734

Generation and characterization of a recombinant/chimeric B72.3 (human gamma 1). PMID: 1988082

A simple and sensitive assay for determination of human anti-idiotypic anti-B72.3 antibodies, which is not affected by the presence of tumour-associated glycoprotein 72. PMID: 8721411

Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies. PMID: 3396011

Frequent anti-V-region immune response to mouse B72.3 monoclonal antibody. PMID: 1373150

Expression in COS cells of a mouse-human chimaeric B72.3 antibody. PMID: 3508296

Identification of adenocarcinoma in cytospin preparations of effusions using monoclonal antibody B72.3. PMID: 3524191

Immunohistochemical staining with monoclonal Ab B72.3 in benign and malignant breast disease. PMID: 2301698

Pharmacokinetic evaluation of technetium-99-metallothionein-conjugated mouse monoclonal antibody B72.3 in rhesus monkeys. PMID: 2754490

Comparison of two sialosyl-Tn binding monoclonal antibodies (MLS102 and B72.3) in detecting pancreatic cancer. PMID: 8282261

Antibody imaging in breast cancer. PMID: 9122722

Phase I study of 90Y-labeled B72.3 intraperitoneal administration in patients with ovarian cancer: effect of dose and EDTA coadministration on pharmacokinetics and toxicity. PMID: 10353726

Radioiodinated anti-TAG-72 humanized CH2 domain-deleted antibody. PMID: 20641585

Phenotypic characterization of lung cancers in fine needle aspiration biopsies using monoclonal antibody B72.3. PMID: 3022920

Evaluation of immunoreactivity of normal tissues from dogs, using monoclonal antibody B72.3. PMID: 7978655

Comparative biodistributions of indium-111-labelled macrocycle chimeric B72.3 antibody conjugates in tumour-bearing mice. PMID: 8018538

Localization of colorectal carcinoma by rhenium-188-labeled B72.3 antibody in xenografted mice. PMID: 9637278

Autoradiographic evaluation of radiolabeled monoclonal antibody B72.3 distribution in tumor and lymph nodes of adenocarcinoma patients. PMID: 7645989

Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. PMID: 3516392

Radioiodinated anti–TAG-72 CC49 (Fab’)2 antibody fragment. PMID: 20641775

Immunohistochemical examination of anti-STn monoclonal antibodies LLU9B4, B72.3, and B35.2 for their potential use as tumor markers. PMID: 18299983

Pharmacokinetics and immune response of 131I-chimeric mouse/human B72.3 (human gamma 4) monoclonal antibody in humans. PMID: 1913665

Immunohistochemical analysis of pulmonary and pleural neoplasms with monoclonal antibodies B72.3 and CSLEX-1. PMID: 1972825

Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3. PMID: 3793270

Lymphoscintigraphy of human colorectal carcinoma metastases in athymic mice by use of radioiodinated B72.3 monoclonal antibody. PMID: 3473248

Radioimmunoguided surgery using iodine 125 B72.3 in patients with colorectal cancer. PMID: 1998477

Highly Sensitive Label-Free Immunosensor based on 5-Sulfosalicylic Acid Doped Poly(2-chloroaniline) for Detection of CA72-4 in Gastric Cancer., PMID:40359729

A Dual Nano-Signal Probe-Based Electrochemical Immunosensor for the Simultaneous Detection of Two Biomarkers in Gastric Cancer., PMID:39996982

Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression., PMID:39920693

An ultrasensitive sandwich-type electrochemical immunosensor based on rGO-TEPA/ZIF67@ZIF8/Au and AuPdRu for the detection of tumor markers CA72-4., PMID:38878457

Antibody engineering to generate anti-tumor-associated glycoprotein 72 mouse recombinant CC49 IgG with improved solubility, purity, and thermal stability., PMID:38145790

The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen., PMID:37828556

Prevalence of elevated Anti-p53 in Chinese patients with upper gastrointestinal or colorectal cancer., PMID:35345938

Electrochemiluminescent immunoassay for the determination of CA15-3 and CA72-4 using graphene oxide nanocomposite modified with CdSe quantum dots and Ru(bpy)3 complex., PMID:34184115

Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers., PMID:33247667

First clinical study of a pegylated diabody 124I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers., PMID:33052222

Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models., PMID:32871754

TAG-72-Targeted α-Radionuclide Therapy of Ovarian Cancer Using 225Ac-Labeled DOTAylated-huCC49 Antibody., PMID:32620701

Improved targeting of an anti-TAG-72 antibody drug conjugate for the treatment of ovarian cancer., PMID:32368864

Humanized Anti-Tumor-Associated Glycoprotein-72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models., PMID:32217350

Frequency of BRCA1 and BRCA2 Mutations in Individuals with Breast and Ovarian Cancer in a Chinese Hakka Population Using Next-Generation Sequencing., PMID:32101877

The prognostic role of tumor associated glycoprotein 72 (TAG-72) in stage II and III colorectal adenocarcinoma., PMID:30466765

Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity., PMID:30303958

Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice., PMID:29728559

Linker engineering in anti-TAG-72 antibody fragments optimizes biophysical properties, serum half-life, and high-specificity tumor imaging., PMID:29669811

Antibody-sandwich ELISA analysis of a novel blood biomarker of CST4 in gastrointestinal cancers., PMID:29636621

A 3E8.scFv.Cys-IR800 Conjugate Targeting TAG-72 in an Orthotopic Colorectal Cancer Model., PMID:28643153

Improving theranostics in pancreatic cancer., PMID:28513912

In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme., PMID:28505463

Pretargeting with bispecific fusion proteins facilitates delivery of nanoparticles to tumor cells with distinct surface antigens., PMID:28363519

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer., PMID:28344808

A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio., PMID:28292939

Searching for New Biomarkers and the Use of Multivariate Analysis in Gastric Cancer Diagnostics., PMID:27069188

CdSe/ZnS Quantum Dot-Labeled Lateral Flow Strips for Rapid and Quantitative Detection of Gastric Cancer Carbohydrate Antigen 72-4., PMID:26969591

Rapid detection and quantification of tumor marker carbohydrate antigen 72-4 (CA72-4) using a superparamagnetic immunochromatographic strip., PMID:26825343

Role of tumor-associated glycoprotein-72 in the progression of endometrial adenocarcinoma: a proposed study., PMID:25769704

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma., PMID:25762629

Sandwich-type electrochemical immunosensor using dumbbell-like nanoparticles for the determination of gastric cancer biomarker CA72-4., PMID:25618672

[Preparation and characterization of the monoclonal antibodies against human CA19-9 and establishment of a sandwich CLIA system]., PMID:25481186

Ultrasensitive electrochemical immunosensor for carbohydrate antigen 72-4 based on dual signal amplification strategy of nanoporous gold and polyaniline-Au asymmetric multicomponent nanoparticles., PMID:25194795

[Preparation and characterization of the monoclonal antibodies against human CA15-3 and establishment of a sandwich CLIA system]., PMID:24405600

Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach., PMID:24210286

New optical method for enhanced detection of colon cancer by capsule endoscopy., PMID:23969635

Development of oligoclonal nanobodies for targeting the tumor-associated glycoprotein 72 antigen., PMID:23015323

Genetically engineered T cells bearing chimeric nanoconstructed receptors harboring TAG-72-specific camelid single domain antibodies as targeting agents., PMID:22902507

Engineering of near IR fluorescent albumin nanoparticles for in vivo detection of colon cancer., PMID:22891637

Oncologic theranostics: recognition of this concept in antigen-directed cancer therapy for colorectal cancer with anti-TAG-72 monoclonal antibodies., PMID:21902525

Antigen-directed cancer surgery for primary colorectal cancer: 15-year survival analysis., PMID:21732140

Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages., PMID:21331365

Adding a clearing agent to pretargeting does not lower the tumor accumulation of the effector as predicted., PMID:21204772

Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells., PMID:21172564

124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: preliminary results., PMID:20691066

Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumor-associated glycoprotein 72., PMID:20127951

Biodistribution of HuCC49DeltaCH2-beta-galactosidase in colorectal cancer xenograft model., PMID:19944136

Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice., PMID:19718796

[The determination of medical reference values for tumor markers in cerebrospinal fluid]., PMID:19563718

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-Human CA72-4/TAG72 Antibody (B72.3) [RHK10001]
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