Catalog No.
VHC01801
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
C-X-C motif chemokine 4, PF-4, Oncostatin-A, Endothelial cell growth inhibitor, CXCL4, Iroplact, Platelet factor 4, PF4, SCYB4
Concentration
2.28 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P02776
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0086
Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo., PMID:39464886
Proteomic screening identifies PF4/Cxcl4 as a critical driver of myelofibrosis., PMID:39025985
Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow., PMID:38941534
Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis., PMID:38307410
Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury., PMID:37991024
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis., PMID:36864432
Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner., PMID:36807143
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors., PMID:36640356
CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells., PMID:36614095
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets., PMID:34099640
Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature., PMID:32707718
Novel insights into dendritic cells in the pathogenesis of systemic sclerosis., PMID:31970748
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis., PMID:31043596
Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice., PMID:30744623
Surgical trauma contributes to progression of colon cancer by downregulating CXCL4 and recruiting MDSCs., PMID:30055136
CXCL4-induced macrophages in human atherosclerosis., PMID:28899579
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion., PMID:25326802
The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1., PMID:24385911
Platelet factor 4 mediates vascular smooth muscle cell injury responses., PMID:23568488
Alloantibody induced platelet responses in transplants: potent mediators in small packages., PMID:22789623
Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor., PMID:22645343
CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment., PMID:20961394
The COOH-terminal peptide of platelet factor-4 variant (CXCL4L1/PF-4var47-70) strongly inhibits angiogenesis and suppresses B16 melanoma growth in vivo., PMID:20215425
Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis., PMID:20004006
CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages., PMID:19910578
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice., PMID:19122657
Platelet-derived chemokines in vascular biology., PMID:17479180
Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo., PMID:17032923
Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro., PMID:15910246
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4., PMID:12782716
For research use only. Not for human or drug use.
