Anti-AGR2 Polyclonal Antibody

Catalog No.

PHB81901

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AGR2 (Arg21-Leu175).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

AGR2,AG-2,AG2,Anterior gradient protein 2 homolog,hAG-2,HPC8,Secreted cement gland protein XAG-2 homolog

Purification

Purified by antigen affinity column.

Accession

O95994

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

DR5 disulfide bonding functions as a sensor and effector of protein folding stress., PMID:40105733

Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation., PMID:39971962

Amelioration of LPS-Induced Jejunum Injury and Mucus Barrier Damage in Mice by IgY Embedded in W/O/W Emulsion., PMID:39767078

A High-Affinity Monoclonal Antibody Against the Pancreatic Ductal Adenocarcinoma Target, Anterior Gradient-2 (AGR2/PDIA17)., PMID:39727484

Multiplexed immunoassay for a serum autoantibody biomarker panel in diagnostic and prognostic prediction of canine mammary tumors., PMID:39639821

Prevalence and Significance of AGR2 Expression in Human Cancer., PMID:39533806

AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells., PMID:38822246

Prostate cancer research: tools, cell types, and molecular targets., PMID:38595814

DR5 disulfide bonding as a sensor and effector of protein folding stress., PMID:38496520

Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study., PMID:38288749

Anterior gradient-2 regulates cell communication by coordinating cytokine-chemokine signaling and immune infiltration in breast cancer., PMID:36853166

Construction and stable gene expression of AGR2xPD1 bi-specific antibody that enhances attachment between T-Cells and lung tumor cells, suppress tumor cell migration and promoting CD8 expression in cytotoxic T-cells., PMID:36685298

Bronchodilatory effect of higenamine as antiallergic asthma treatment., PMID:35410888

Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to β-catenin that requires AGR2 dimerization and adhesion domains., PMID:34399098

An Ultrasensitive Biosensor for Detection of Femtogram Levels of the Cancer Antigen AGR2 Using Monoclonal Antibody Modified Screen-Printed Gold Electrodes., PMID:34200338

Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer., PMID:34092584

Dietary Soy Protein Isolate Attenuates Intestinal Immunoglobulin and Mucin Expression in Young Mice Compared with Casein., PMID:32911830

Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain., PMID:32140067

Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients., PMID:32024004

Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration., PMID:31710263

The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer., PMID:31644911

Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC., PMID:31436131

AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting., PMID:31303962

Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study., PMID:30685412

Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab., PMID:30647455

Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2)., PMID:29937991

A novel lentiviral scFv display library for rapid optimization and selection of high affinity antibodies., PMID:29559238

Pro-metastatic activity of AGR2 interrupts angiogenesis target bevacizumab efficiency via direct interaction with VEGFA and activation of NF-κB pathway., PMID:29410027

Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain., PMID:28665039

Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization., PMID:28481872

An efficient method for native protein purification in the selected range from prostate cancer tissue digests., PMID:28061542

Cancer-secreted AGR2 induces programmed cell death in normal cells., PMID:27283903

A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth., PMID:27166154

Mechanism of Action of Secreted Newt Anterior Gradient Protein., PMID:27100463

Binding of anterior gradient 2 and estrogen receptor-α: Dual critical roles in enhancing fulvestrant resistance and IGF-1-induced tumorigenesis of breast cancer., PMID:27063095

Regulation of Gene Expression by Sodium Valproate in Epithelial-to-Mesenchymal Transition., PMID:26286207

Anterior gradient 2 is a binding stabilizer of hypoxia inducible factor-1α that enhances CoCl2 -induced doxorubicin resistance in breast cancer cells., PMID:26079208

New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice., PMID:25646014

Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection., PMID:25644820

Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition., PMID:25418581

Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10., PMID:24768923

A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG)., PMID:24555920

Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions., PMID:24076771

Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein., PMID:23780840

AGR2 expression is regulated by HIF-1 and contributes to growth and angiogenesis of glioblastoma., PMID:23712868

Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models., PMID:22361111

Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine., PMID:22072305

Analysis of EpCAM positive cells isolated from sentinel lymph nodes of breast cancer patients identifies subpopulations of cells with distinct transcription profiles., PMID:21816090

Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree., PMID:21281432

Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells., PMID:21275604

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