Anti-DDX58 Polyclonal Antibody

Catalog No.

PHB74601

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DDX58 (Ile725-Lys925).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Probable ATP-dependent RNA helicase DDX58,Retinoic acid-inducible gene I protein,RIG-1,DEAD box protein 58,RLR-1,DDX58,Retinoic acid-inducible gene 1 protein,Antiviral innate immune response receptor RIG-I,RIG-I-like receptor 1,RIG-I

Purification

Purified by antigen affinity column.

Accession

O95786

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410

Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response., PMID:38331257

Molecular Signatures in Swine Innate and Adaptive Immune Responses to African Swine Fever Virus Antigens p30/p54/CD2v Expressed Using a Highly Efficient Semliki Forest Virus Replicon System., PMID:37298266

Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model., PMID:36851724

RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine., PMID:36426358

Transcriptome analysis reveals similarities and differences in immune responses in the head and trunk kidneys of yellow catfish (Pelteobagrus fulvidraco) stimulated with Aeromonas hydrophila., PMID:36055554

Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes., PMID:35797939

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine., PMID:35577151

T cell and memory B cell responses in tetravalent DNA, tetravalent inactivated and tetravalent live-attenuated prime-boost dengue vaccines in rhesus macaques., PMID:34823910

TLR genetic variation is associated with Rotavirus-specific IgA seroconversion in South African Black infants after two doses of Rotarix vaccine., PMID:34740476

A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine., PMID:34603303

NanoString technology distinguishes anti-TIF-1γ+ from anti-Mi-2+ dermatomyositis patients., PMID:34043263

Higher-order assemblies in immune signaling: supramolecular complexes and phase separation., PMID:33835418

Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway., PMID:33593967

From Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies., PMID:33314705

Host gene expression modulated by Zika virus infection of human-293 cells., PMID:33059318

Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma., PMID:32816890

Combined Intranasal Nanoemulsion and RIG-I Activating RNA Adjuvants Enhance Mucosal, Humoral, and Cellular Immunity to Influenza Virus., PMID:32491861

Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy., PMID:32427578

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade., PMID:32371478

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade., PMID:31740809

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade., PMID:31645452

Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages., PMID:31562757

N6-Methyladenosine Modification Controls Circular RNA Immunity., PMID:31474572

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles., PMID:31200750

CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways., PMID:31195953

Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells., PMID:31088527

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters., PMID:30909389

Diagnostic potential of sarcoplasmic myxovirus resistance protein A expression in subsets of dermatomyositis., PMID:30267437

Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells., PMID:30087859

Aberrant activation of the type I interferon system may contribute to the pathogenesis of anti-melanoma differentiation-associated gene 5 dermatomyositis., PMID:29947075

Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha., PMID:29247698

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production., PMID:29186193

RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNA., PMID:28806404

Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies., PMID:28286158

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response., PMID:28279563

A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects., PMID:28077601

Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling., PMID:27992555

Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue Vaccine Candidate in Non-human Primates., PMID:27214236

RIG-I ligand enhances the immunogenicity of recombinant H7HA protein., PMID:27106062

Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy., PMID:26923481

[Expression of retinoic acid-I nducible gene I in the muscle tissues of idiopathic inflammatory myopathies]., PMID:26712399

Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I., PMID:26695369

HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?, PMID:26616295

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus., PMID:26506431

Induction of interferon-λ contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells., PMID:26502803

IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation., PMID:26348439

Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant., PMID:26269188

Biology of Zika Virus Infection in Human Skin Cells., PMID:26085147

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