Catalog No.
EHC35101
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Tyr995
Predicted molecular weight
109.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08648
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation., PMID:40501821
Age-Related Dysregulation of α5β1 and αvβ3 Integrin Activity Alters Contractile Properties of Trabecular Meshwork Cells., PMID:40488712
ITGA5 drives angiogenesis in diabetic retinopathy via TAK-1/NF-kB activation., PMID:40410450
Load activated FGFR and beta1 integrins target distinct chondrocyte mechano-response genes., PMID:40379111
Interaction of Serratia proteamaculans with Integrins Activates Invasion-Promoting Signaling Pathways., PMID:40362195
Digoxin promotes anoikis of circulating cancer cells by targeting Na+/K+-ATPase α3-isoform., PMID:40350473
TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression., PMID:40328789
ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway., PMID:40253517
Laminin α5: a key factor in tumor metastasis., PMID:40214832
Identification of potential cell surface targets in patient-derived cultures toward photoimmunotherapy of high-grade serous ovarian cancer., PMID:40205302
New insights on the protection of endangered aquatic species: Embryotoxicity effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) via integrin-mediated oxidative stress and inflammatory pathways in Siberian sturgeon, Acipenser baerii., PMID:40185295
[CEACAM6 inhibits proliferation and migration of nasopharyngeal carcinoma cells by suppressing epithelial-mesenchymal transition]., PMID:40159971
13-Methylpalmatine alleviates bleomycin-induced pulmonary fibrosis by suppressing the ITGA5/TGF-β/Smad signaling pathway., PMID:40023972
Effects of Cell Seeding Density, Extracellular Matrix Composition, and Geometry on Yes-Associated Protein Translocation in Corneal Fibroblasts., PMID:39940950
Caffeic acid stimulates migration and invasion of human trophoblast HTR-8/SVneo cells., PMID:39918297
Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cells., PMID:39883230
Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies., PMID:39829438
The regulatory role of integrin in gastric cancer tumor microenvironment and drug resistance., PMID:39798809
Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts., PMID:39785683
White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp., PMID:39637952
The NF-κB-HE4 axis: A novel regulator of HE4 secretion in ovarian cancer., PMID:39621651
Suppression of Dad1 induces cardiomyocyte death by weakening cell adhesion., PMID:39611549
Integrin-α5 expression and its role in non-small cell lung cancer progression., PMID:39581761
Nano-scale dangers: Unravelling the impact of nanoplastics on human trophoblast invasion., PMID:39580066
Myofibroblast-derived extracellular vesicles facilitate cancer stemness of hepatocellular carcinoma via transferring ITGA5 to tumor cells., PMID:39574133
Vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation in the heart., PMID:39554004
Discovery of Novel SIRT3 Inhibitors for the Cancer Differentiation Therapy by Structural Modification., PMID:39527674
Intercellular junction-driven stromal cell stacking in a confined 3D microcavity., PMID:39525363
Edaravone Dexborneol protects against blood-brain barrier disruption following cerebral ischemia/reperfusion by upregulating pericyte coverage via vitronectin-integrin and PDGFB/PDGFR-β signaling., PMID:39486750
Pericytes Modulate Third-Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR-Mutated Lung Cancer Cells Through IL32-β5-Integrin Paracrine Signaling., PMID:39435643
ITGA5 is associated with prognosis marker and immunosuppression in head and neck squamous cell carcinoma., PMID:39375732
Modulation of αv integrins by lebecetin, a viper venom-derived molecule, in experimental neuroinflammation and demyelination models., PMID:39333683
Integrins α5β1 and αvβ3 Differentially Participate in the Recruitment and Reprogramming of Tumor-associated Macrophages in the In Vitro and In Vivo Models of Breast Tumor., PMID:39330703
Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells., PMID:39316261
Hypoxia induces reversible gill remodeling in largemouth bass (Micropterus salmoides) through integrins-mediated cell adhesion., PMID:39307257
Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFβ1-Smad3-intergin αV signaling axis Based on optical image diagnosis., PMID:39299505
Unraveling the molecular basis for effective regulation of integrin α5β1 for enhanced therapeutic interventions., PMID:39236588
Hypoxia-driven heterogeneous expression of α5 integrin in glioblastoma stem cells is linked to HIF-2α., PMID:39154793
Structural modification of 2-phenylquinoline-4-carboxylic acid containing SIRT3 inhibitors for the cancer differentiation therapy., PMID:39085939
Overcoming Vemurafenib Resistance in Metastatic Melanoma: Targeting Integrins to Improve Treatment Efficacy., PMID:39063187
RGD Density on Tadpole Nanostructures Regulates Cancer Stem Cell Proliferation and Stemness., PMID:39056889
Itga5-PTEN signaling regulates striatal synaptic strength and motor coordination in Parkinson's disease., PMID:38993558
PRELP reduce cell stiffness and adhesion to promote the growth and metastasis of colorectal cancer cells by binding to integrin α5., PMID:38992455
Augmenting fibronectin levels in injured adult CNS promotes axon regeneration in vivo., PMID:38944331
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer., PMID:38918360
Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer., PMID:38910148
Fibronectin and vitronectin alleviate adipose-derived stem cells senescence during long-term culture through the AKT/MDM2/P53 pathway., PMID:38902430
Cepharanthine inhibits migration, invasion, and EMT of bladder cancer cells by activating the Rap1 signaling pathway in vitro., PMID:38883391
Integrins play a role in stress relaxation of perivascular adipose tissue., PMID:38880313
Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis., PMID:38844957
For research use only. Not for human or drug use.
