Catalog No.
PHB26901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PRDM1 (His493-Lys678).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
BLIMP-1,PRDI-BF1,PRDI-binding factor 1,BLIMP1,Positive regulatory domain I-binding factor 1,Beta-interferon gene positive regulatory domain I-binding factor,PR domain-containing protein 1,PR domain zinc finger protein 1,PRDM1
Purification
Purified by antigen affinity column.
Accession
O75626
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Blocking plasma cell fate enhances antigen-specific presentation by B cells to boost anti-tumor immunity., PMID:40360528
[Relapse-related candidate genes and their clinicopathological connections of diffuse large B cell lymphoma]., PMID:40159024
Gut IgA-antibody secreting cells segregate into four Blimp1+ subsets based on differential expression of IgA and Ki-67 and are retained following prolonged αCD20 B cell depletion in mice., PMID:40073093
Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts., PMID:39923238
RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses., PMID:39824820
TP53 Mutation Is the Only Robust Mutational Biomarker for Outcome Found in a Consecutive Clinical Cohort of Real-Word Patients With Primary Large B-Cell Lymphoma., PMID:39691999
Assessing human B cell responses to influenza virus vaccines and adjuvants in a PBMC-derived in vitro culture system., PMID:39616951
Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis., PMID:39612915
Antimalarial Drug Artemotil Promotes Induction of Type 1 Regulatory T Cells., PMID:39607628
Blunting specific T-dependent antibody responses with engineered "decoy" B cells., PMID:39192583
Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity., PMID:39121849
Inhibition of GRK2 ameliorates the pristane-induced mouse SLE model by suppressing plasma cells differentiation., PMID:38936060
Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers., PMID:38838672
Interleukin 21 promotes IgG1+ plasma cell differentiation instead of class switching to IgE via Blimp1 expression., PMID:38794862
Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions., PMID:38605225
Leukemic presentation and progressive genomic alterations of MCD/C5 diffuse large B-cell lymphoma (DLBCL)., PMID:37730436
Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease., PMID:37561593
Follicular Helper T Cells in Peyer's Patches and Galactose- Deficient Iga1 Contribute to Iga Nephropathy., PMID:37475555
Potential Pathogenic Impact of Cow's Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma., PMID:37047075
The specific phagocytosis regulators could predict recurrence and therapeutic effect in thyroid cancer: A study based on bioinformatics analysis., PMID:36930113
Waldenström Macroglobulinemia and Non-IgM-Type Lymphoplasmacytic Lymphoma Are Genetically Similar., PMID:36917966
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499
The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells., PMID:36618345
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses., PMID:36223741
Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis., PMID:36081178
Epigenetic remodeling by vitamin C potentiates plasma cell differentiation., PMID:36069787
Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells., PMID:35921418
Romidepsin (FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway., PMID:35557040
Plasmablast-like Phenotype Among Antigen-Experienced CXCR5-CD19low B Cells in Systemic Lupus Erythematosus., PMID:35507291
Blimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2., PMID:35386001
Conserved and Unique Functions of Blimp1 in Immune Cells., PMID:35154079
NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs., PMID:35069572
Reprogramming of Chinese hamster ovary cells towards enhanced protein secretion., PMID:34929420
A System for In Vitro Generation of Mature Murine Plasma Cells Uncovers Differential Blimp-1/Prdm1 Promoter Usage., PMID:34911772
Dysregulated MDR1 by PRDM1/Blimp1 Is Involved in the Doxorubicin Resistance of Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma., PMID:34844236
Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade., PMID:34798898
AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation., PMID:34521812
Properties of regulatory B cells regulating B cell targets., PMID:34327838
Dexamethasone reduces autoantibody levels in MRL/lpr mice by inhibiting Tfh cell responses., PMID:34318604
Overexpression of transcription factor BLIMP1/prdm1 leads to growth inhibition and enhanced secretory capacity in Chinese hamster ovary cells., PMID:34265400
The Immunity-malignancy equilibrium in multiple myeloma: lessons from oncogenic events in plasma cells., PMID:34117720
Minimalistic In Vitro Culture to Drive Human Naive B Cell Differentiation into Antibody-Secreting Cells., PMID:34066151
Imaging of Bone Marrow Plasma Cells and of Their Niches., PMID:34057723
The diversity of the plasmablast signature across species and experimental conditions: A meta-analysis., PMID:34041745
Homotypic aggregates contribute to heterogeneity in B cell fates due to an intrinsic gradient of stimulant exposure., PMID:34029570
Follicular regulatory T cells produce neuritin to regulate B cells., PMID:33711260
Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help., PMID:33613551
Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis., PMID:33468194
Increased Expression of B Lymphocyte Induced Maturation Protein 1 (BLIMP1) in Patients with Common Variable Immunodeficiency (CVID)., PMID:33463110
Epigenetics of the antibody and autoantibody response., PMID:33176228
For research use only. Not for human or drug use.
