Catalog No.
DHJ94702
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Applications
Research Grade Biosimilar
Target
FcRL5, FCRH5, FCRL5, Fc receptor homolog 5, FcRH5, CD307e, FcR-like protein 5, IRTA2, Immune receptor translocation-associated protein 2, BXMAS1, Fc receptor-like protein 5
Concentration
3 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q96RD9
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
RG7598,CD307
Clone ID
RG7598
Note
For research use only. Not suitable for clinical or therapeutic use.
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy., PMID:11290337
Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies., PMID:15671532
Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1., PMID:16439682
Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera., PMID:16681430
Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia., PMID:18802695
A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis., PMID:21937757
Fc receptor-like 5 promotes B cell proliferation and drives the development of cells displaying switched isotypes., PMID:22028333
Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG., PMID:22491254
FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma., PMID:22807577
Micro-volume wall-less immunoassays using patterned planar plates., PMID:23380873
Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors., PMID:23616577
CD21(-/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis., PMID:24504816
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure., PMID:25993340
B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT., PMID:27065451
Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells., PMID:27076679
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing., PMID:28262555
High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis., PMID:28973482
Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants., PMID:29101848
CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity., PMID:30107486
HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis., PMID:30333570
Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties., PMID:30550367
Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma., PMID:30718503
FCRL5+ Memory B Cells Exhibit Robust Recall Responses., PMID:31042472
Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis., PMID:32841219
Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria., PMID:34758841
[Bispecific antibodies in multiple myeloma]., PMID:34920804
SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease., PMID:34936684
B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection., PMID:34990486
Regulation of B-cell function and expression of CD11c, T-bet, and FcRL5 in response to different activation signals., PMID:38700378
Just scratching the surface: novel treatment approaches for multiple myeloma targeting cell membrane proteins., PMID:38961233
Allostimulation leads to emergence of a human B cell population with increased expression of HLA class I antigen presentation-associated molecules and the immunoglobulin receptor FcRL5., PMID:38992496
Management of Toxicities Associated with BCMA, GPRC5D, and FcRH5-Targeting Bispecific Antibodies in Multiple Myeloma., PMID:39145912
For research use only. Not for human or drug use.
