Anti-MACROH2A1 Polyclonal Antibody

Catalog No.

PHB17201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MACROH2A1 (Ile109-Leu369).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Histone macroH2A1,mH2A1,H2A/y,MACROH2A1,Medulloblastoma antigen MU-MB-50.205,Core histone macro-H2A.1,H2AFY,Histone H2A.y

Purification

Purified by antigen affinity column.

Accession

O75367

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nuclear PD-L1 compartmentalization suppresses tumorigenesis and overcomes immunocheckpoint therapy resistance in mice via histone macroH2A1., PMID:39545415

Epigenetic regulation of cell state by H2AFY governs immunogenicity in high-risk neuroblastoma., PMID:39255035

Integrated spatial genomics reveals global architecture of single nuclei., PMID:33505024

The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate., PMID:28564596

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis., PMID:25526730

Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains., PMID:23118866

X chromosome inactivation and differentiation occur readily in ES cells doubly-deficient for macroH2A1 and macroH2A2., PMID:21738686

The histone H2A variant macroH2A1 does not localize to the centrosome., PMID:21364955

Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome., PMID:18936163

Epigenetic processes in a tetraploid mammal., PMID:18758856

A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis., PMID:18227505

Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist., PMID:12356914

Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos., PMID:10804171

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals., PMID:9634239

Developmental and tissue expression patterns of histone macroH2A1 subtypes., PMID:9138085

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