Catalog No.
DHB95603
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
Fusion - [IL1RAP (interleukin-1 receptor accessory protein) - IL1R1 (type 1 interleukin-1 receptor, interleukin 1 receptor, type I)]2 - IGHG1 Fc (Fragment constant)
Applications
Research Grade Biosimilar
Target
Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta
Concentration
1.72 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01584
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CAS: 501081-76-1
Clone ID
Rilonacept
Note
For research use only. Not suitable for clinical or therapeutic use.
Inhibition of interleukin-1 with rilonacept is not effective in cold urticaria-Results of a randomized, placebo-controlled study., PMID:36973954
New Developments in the Management of Recurrent Pericarditis., PMID:37075863
The Identification of Potential Drugs for Dengue Hemorrhagic Fever: Network-Based Drug Reprofiling Study., PMID:38935956
Interleukin-1 Blockers for the Treatment of Recurrent Pericarditis: Pathophysiology, Patient-Reported Outcomes, and Perspectives., PMID:37163222
Cardiac magnetic resonance imaging of pericardial diseases: a comprehensive guide., PMID:37207354
Pericardial late gadolinium enhancement and time to recurrence: a substudy from RHAPSODY, a phase 3 clinical trial of rilonacept in recurrent pericarditis., PMID:39044797
Key Articles and Guidelines in the Management of Pericardial Syndromes., PMID:37306306
Tuberculosis in children and adolescents with rheumatic diseases using biologic agents: an integrative review., PMID:37436237
Paradigm Shift in Diagnosis and Targeted Therapy in Recurrent Pericarditis., PMID:37458866
Interleukin-1β inhibitors for the management of acute gout flares: a systematic literature review., PMID:37491293
IL-1 blockade in cardiovascular disease: an appraisal of the evidence across different inflammatory paradigms., PMID:37705370
Efficacy and safety of anti-interleukin-1 treatment in familial Mediterranean fever patients: a systematic review and meta-analysis., PMID:37769252
Interleukin-1β converting enzyme (ICE): A comprehensive review on discovery and development of caspase-1 inhibitors., PMID:37857145
Successful Treatment of Recurrent Pericarditis With Rilonacept in Acute Promyelocytic Leukemia., PMID:38094210
Correction: Transition to rilonacept monotherapy from oral therapies in patients with recurrent pericarditis., PMID:38123179
The clinical role of anakinra in the armamentarium against familial Mediterranean fever., PMID:38133629
Comparative Risk of Gout Flares When Initiating or Escalating Various Urate-Lowering Therapy: A Systematic Review With Network Meta-Analysis., PMID:38303574
Safety and Efficacy of Interleukin-1β Inhibitors for Hidradenitis Suppurativa: A Systematic Review., PMID:38323589
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)., PMID:38376736
Biomaterials Functionalized with Inflammasome Inhibitors-Premises and Perspectives., PMID:38391885
Sustained Pericarditis Recurrence Risk Reduction With Long-Term Rilonacept., PMID:38471825
Rilonacept use in lupus pericarditis., PMID:38526001
Interleukin inhibitors and the associated risk of candidiasis., PMID:38605952
Comparative efficacy and safety of different drugs in patients with systemic juvenile idiopathic arthritis: A systematic review and network meta-analysis., PMID:38701278
Goflikicept and Related IL-1 Inhibitors in the Treatment of Recurrent Pericarditis., PMID:38709249
Efficacy and safety of biologic drugs in Still's disease: a systematic review and network meta-analysis of randomized controlled trials., PMID:38775654
Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From the RHAPSODY Long-term Extension., PMID:39022168
Identification of critical genes and metabolic pathways in rheumatoid arthritis and osteoporosis toward drug repurposing., PMID:39079412
Newer Therapies in Rheumatology., PMID:39084836
Pericardial Diseases: International Position Statement on New Concepts and Advances in Multimodality Cardiac Imaging., PMID:39111992
Longitudinal cardiac magnetic resonance imaging following clinical response to rilonacept and prior to recurrence upon treatment suspension: a RHAPSODY subgroup analysis., PMID:39172552
Reply to Albulushi et al.-Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From RHAPSODY Long-term Extension., PMID:39211751
Queries on Rilonacept in COVID-19 and Vaccine-Linked Pericarditis: Addressing Study Outcomes., PMID:39211756
Clinical Utility of Rilonacept for the Treatment of Recurrent Pericarditis: Design, Development, and Place in Therapy., PMID:39247795
Long-Standing Chronic Recurrent Pericarditis Managed With Advanced Diagnostic and Therapeutic Methods., PMID:39359977
Unveiling Rheumatoid Arthritis: Recurrent Pericarditis as the Sentinel Manifestation., PMID:39484330
Comparative efficacy and safety of colchicine and interleukin-1 antagonists in recurrent pericarditis: a network meta-analysis., PMID:39705019
Assessing the Impact of Rilonacept on Lipid Profiles in Patients With Recurrent Pericarditis., PMID:39791103
Advancement in the Treatment of Recurrent Pericarditis: Exploring Innovative Therapeutic Options., PMID:39821260
Background and Clinical Features of a Unique and Mysterious Autoinflammatory Disease, Schnitzler Syndrome., PMID:39859314
[Pericarditis: state-of-the art and perspectives in 2025]., PMID:40045835
Deficiency of interleukin-1 receptor antagonist: A systematic review., PMID:40060136
The Role of the Advanced Practice Provider in a Pericardial Center of Excellence., PMID:40063308
The Golden Card of Interleukin-1 Blockers in Systemic Inflammasomopathies of Childhood., PMID:40076498
Rilonacept in Refractory Immune Checkpoint Inhibitor-Induced Recurrent Pericarditis: A Potential Treatment Option., PMID:40118613
Current Drug Treatment for Acute and Recurrent Pericarditis., PMID:40119189
Tumor Necrosis Factor Receptor-Associated Periodic Syndrome: Genetics, Autoinflammation, and Recurrent Pericarditis., PMID:40250904
Comprehensive Clinical Analysis of Rilonacept in the Treatment of Cryopyrin-Associated Periodic Syndromes: A Systematic Review., PMID:40370685
Resolution of Colchicine-Resistant, Corticosteroid-Dependent Acute Idiopathic Recurrent Pericarditis With Rilonacept: A Case Report., PMID:40376326
Running into trouble: exercise-exacerbated recurrent pericarditis-a case report., PMID:40438423
For research use only. Not for human or drug use.
