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Research Grade Teplizumab

Catalog #:   DHC27703 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC27703

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07766

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

MGA-031 / MGA031, PRV-031, CAS: 876387-05-2

Clone ID

Teplizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Teplizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes, PMID: 31180194

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial, PMID: 21719095

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders, PMID: 23835333

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis, PMID: 30569273

Antibodies to watch in 2020, PMID: 31847708

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes, PMID: 28664195

Teplizumab for treatment of type 1 diabetes mellitus, PMID: 22968521

Teplizumab in Relatives at Risk for Type 1 Diabetes, PMID: 31693815

Teplizumab in Relatives at Risk for Type 1 Diabetes, PMID: 31693816

Teplizumab in Relatives at Risk for Type 1 Diabetes, PMID: 31693817

Teplizumab therapy for type 1 diabetes, PMID: 20095914

Teplizumab in Relatives at Risk for Type 1 Diabetes. Reply, PMID: 31693818

New Frontiers in the Treatment of Type 1 Diabetes, PMID: 31839487

Teplizumab delays onset of type 1 diabetes mellitus, PMID: 31243389

Safety and Efficacy of Teplizumab for Treatment of Type One Diabetes Mellitus: A Systematic Review and Meta-analysis, PMID: 33302842

Cost Effectiveness of Teplizumab for Prevention of Type 1 Diabetes Among Different Target Patient Groups, PMID: 32960433

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside, PMID: 27161438

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes, PMID: 32023396

Changing the landscape for type 1 diabetes: the first step to prevention, PMID: 31533907

Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development, PMID: 24517093

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals, PMID: 33658358

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial, PMID: 23086558

Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protégé trial, PMID: 23801579

Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients, PMID: 22277969

Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes, PMID: 33847731

Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes, PMID: 26518356

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years, PMID: 19443276

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes, PMID: 32833543

Prospects for therapeutic tolerance in humans, PMID: 24378931

Insulin is necessary but not sufficient: changing the therapeutic paradigm in type 1 diabetes, PMID: 32789003

Immunotherapies currently in development for the treatment of type 1 diabetes, PMID: 26364507

Immunotherapies in diabetes mellitus type 1, PMID: 22703858

Microbiota control immune regulation in humanized mice, PMID: 29093268

Anti-CD3 drug keeps diabetes at bay, PMID: 31578500

Combination therapies in the context of anti-CD3 antibodies for the treatment of autoimmune diseases, PMID: 23254986

Traveling down the Long Road to Type 1 Diabetes Mellitus Prevention, PMID: 31180193

Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D, PMID: 31157632

Anti-CD3 clinical trials in type 1 diabetes mellitus, PMID: 23726024

Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance, PMID: 31523950

Prevention versus intervention of type 1 diabetes, PMID: 23803322

Preclinical efficacy of humanized, non-FcγR-binding anti-CD3 antibodies in T-cell acute lymphoblastic leukemia, PMID: 32483610

Primary and secondary prevention of Type 1 diabetes, PMID: 23231526

Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes, PMID: 28844471

Immune therapy and β-cell death in type 1 diabetes, PMID: 23423576

Immunomodulators: Cell savers, PMID: 22616095

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes, PMID: 33007232

Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease, PMID: 25437293

Anti-CD3 mAbs for treatment of type 1 diabetes, PMID: 19319985

Type 1 diabetes pathogenesis - Prevention???, PMID: 25941654

A future for CD3 antibodies in immunotherapy of type 1 diabetes, PMID: 30612137

Type 1 diabetes mellitus prevention: present and future., PMID:40527975

Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes., PMID:40447640

The Use of Continuous Glucose Monitoring to Diagnose Stage 2 Type 1 Diabetes., PMID:40444471

The Role of the Diabetes Care and Education Specialist in Screening and Monitoring for Type 1 Diabetes., PMID:40411371

Teplizumab: a promising intervention for delaying type 1 diabetes progression., PMID:40357199

An Exploratory Cost-Effectiveness Analysis of Immune Therapy in Delaying the Initiation of Automated Insulin Delivery Systems in Type 1 Diabetes., PMID:40354170

Paediatric screening in Italy as a gateway to secondary prevention in type 1 diabetes., PMID:40339706

Teplizumab: Not all that glitters is gold., PMID:40329663

Quality of life and physical activity in type 1 diabetes., PMID:40312313

Immunomodulatory agents and cell therapy for patients with type 1 diabetes., PMID:40215356

Immunotherapy as a treatment for type 1 diabetes mellitus in children and young adults: A comprehensive systematic review and meta-analysis., PMID:40215252

M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-Term Response to Preventive Immunotherapy., PMID:40208750

Pharmacotherapeutic strategies to promote regulatory T cell function in autoimmunity., PMID:40187268

Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening., PMID:40134221

Anti-diabetic Biologicals: Exploring the Role of Different Analytical Techniques., PMID:40088445

Pharmacotherapy of type 1 diabetes - part 2 Today., PMID:40082213

Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes., PMID:40073269

Pharmacotherapy of type 1 diabetes - part 3: tomorrow., PMID:40056035

Immunotherapies for prevention and treatment of type 1 diabetes., PMID:40033931

[Early diagnosis of type 1 diabetes : a step towards precision medicine]., PMID:39976138

Real-world experiences of adult individuals or caregivers of children who received teplizumab treatment in stage 2 type 1 diabetes., PMID:39949173

Immunotherapy in Type 1 Diabetes: Emerging Therapies and Future Directions., PMID:39948801

Corrigendum: Shifting the paradigm of type 1 diabetes: a narrative review of disease-modifying therapies., PMID:39936148

Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators., PMID:39929732

Emerging Immunotherapies for Disease Modification of Type 1 Diabetes., PMID:39873914

Pre-Type 1 Diabetes in Adolescents and Teens: Screening, Nutritional Interventions, Beta-Cell Preservation, and Psychosocial Impacts., PMID:39860389

An Atypical Presentation of Cytokine Release Syndrome With Signs of Arthritis During Treatment With Teplizumab in a Pediatric Patient., PMID:39841557

Current perspectives and the future of disease-modifying therapies in type 1 diabetes., PMID:39817218

Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation., PMID:39735417

ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes., PMID:39662065

Time to reframe the disease staging system for type 1 diabetes., PMID:39608963

Shifting the paradigm of type 1 diabetes: a narrative review of disease modifying therapies., PMID:39568817

Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab., PMID:39560746

Immunotherapy in type 1 diabetes: Novel pathway to the future ahead., PMID:39493558

Type 1 diabetes: immune pathology and novel therapeutic approaches., PMID:39469552

Latent Autoimmune Diabetes in Adults Following Bariatric Surgery-Induced Hypoglycemia in a 36-Year-Old Woman., PMID:39463547

Emerging Concepts and Success Stories in Type 1 Diabetes Research: A Road Map for a Bright Future., PMID:39446565

Immunotherapy-Based Strategies for Treatment of Type 1 Diabetes., PMID:39401495

The Benefits of Using Continuous Glucose Monitoring to Diagnose Type 1 Diabetes., PMID:39394887

The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation., PMID:39284671

Safety of teplizumab in patients with high-risk for diabetes mellitus type 1: A systematic review., PMID:39192866

Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop., PMID:39167668

From pre-clinical efficacy to promising clinical trials that delay Type 1 diabetes., PMID:39142538

Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes., PMID:39137044

The Pathogenesis of Type 1 Diabetes., PMID:39134388

Teplizumab's immunomodulatory effects on pancreatic β-cell function in type 1 diabetes mellitus., PMID:39123252

Exploring Novel Treatment Modalities for Type 1 Diabetes Mellitus: Potential and Prospects., PMID:39120188

Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus: A systematic review and meta-analysis., PMID:39099823

The Role of Teplizumab in Newly Diagnosed Type 1 Diabetes., PMID:38992798

Reply to the Letter to the Editor, Endocrine Practice for "Role of Teplizumab, a Humanized Anti-CD3 Monoclonal Antibody, in Managing Newly Diagnosed Type 1 Diabetes: An Updated Systematic Review and Meta-Analysis"., PMID:38992797

Datasheet

Document Download

Research Grade Teplizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Teplizumab [DHC27703]
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