Catalog No.
PHA97301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human JAK2 (Asn508-Ala800).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Janus kinase 2,JAK2,Tyrosine-protein kinase JAK2,JAK-2
Purification
Purified by antigen affinity column.
Accession
O60674
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2 V617F clonal hematopoiesis-driven atherosclerosis., PMID:40501724
CD19+IL-10+ regulatory B cells induced by IL-12p35 regulates functional T-cell subsets in patients with immune thrombocytopenia., PMID:40415408
VSIG4 Promotes Tumour-Associated Macrophage M2 Polarization and Immune Escape in Colorectal Cancer via Fatty Acid Oxidation Pathway., PMID:40405491
Defective neutrophil clearance in JAK2V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24., PMID:40373279
Emerging Therapeutic Approaches for Anemia in Myelofibrosis., PMID:40317385
Ruxolitinib mediated paradoxical JAK2 hyperphosphorylation is due to the protection of activation loop tyrosines from phosphatases., PMID:40269271
CCL7 promotes macrophage polarization and synovitis to exacerbate rheumatoid arthritis., PMID:40224025
A novel IgD-FcδR blocker, IgD-Fc-Ig fusion protein, effectively alleviates abnormal activation of T cells the disease progression in systemic lupus erythematosus., PMID:40194603
Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications., PMID:40187711
Recurrent ERBB2 alterations are associated with esophageal adenocarcinoma brain metastases., PMID:40061311
Emerging Pathogenetic Mechanisms and New Drugs for Anemia in Myelofibrosis and Myelodysplastic Syndromes., PMID:40056069
Gastric-type endocervical adenocarcinoma, superficial myofibroblastoma, sex cord-stromal tumors, and HSIL in Peutz-Jeghers syndrome: a rare case report, genetic characterization, and review of literature., PMID:40018404
Cellular War: The Dominance Struggle of Polycythemia Vera and Chronic Lymphocytic Leukemia Clones Within a Patient., PMID:39967529
CALR-mutated myeloproliferative neoplasms., PMID:39960832
[Immunohistochemical method of megakaryocytic lineage staining in bone marrow biopsy specimens as an additional pathomorphological differential diagnostic sign of primary myelofibrosis and essential thrombocythemia]., PMID:39943725
Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review., PMID:39931054
Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis., PMID:39928525
Canthaxanthin ameliorates atopic dermatitis in mice by suppressing Th2 immune response., PMID:39787760
Dual efficacy of tocilizumab in managing PD-1 inhibitors-induced myocardial inflammatory injury and suppressing tumor growth with PD-1 inhibitors: a preclinical study., PMID:39752010
Shaping the Future of Myeloproliferative Neoplasm Therapy: Immune-Based Strategies and Targeted Innovations., PMID:39682299
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis., PMID:39636853
Aberrantly Expressed Mitochondrial Lipid Kinase, AGK, Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy., PMID:39636206
Type 2 cytokine-JAK1 signaling is involved in the development of dry skin-induced mechanical alloknesis., PMID:39616021
Efficacy of Daratumumab-Based Regimens for Extramedullary Pulmonary Plasmacytoma: A Case Report., PMID:39544101
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice., PMID:39531316
New approaches to standard of care in early-phase myeloproliferative neoplasms: can interferon-α alter the natural history of the disease?, PMID:39445431
Clonal hematopoiesis and atherosclerosis., PMID:39352379
Inhibition of JAK/STAT3 Expression by Acute Myeloid Leukemia-Targeted Nanoliposome for Chemotherapy Enhancement., PMID:39281932
Dual Role of Necroptosis in Cervical Cancer: Promoting Tumor Aggression and Modulating the Immune Microenvironment via the JAK2-STAT3 Pathway., PMID:39247606
Demethylzeylasteral ameliorates podocyte damage in murine lupus by inhibiting inflammation and enhancing autophagy., PMID:39241387
SOHO State of the Art Updates and Next Questions | Approach to BCR::ABL1-Like Acute Lymphoblastic Leukemia., PMID:39217000
Pembrolizumab Combined With GDP Regimen Inducing Sustained Remission in Histiocytic Sarcoma: A Case Report., PMID:39215504
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes., PMID:39214514
The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells., PMID:39188724
The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets., PMID:39161981
CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p., PMID:39103836
Simultaneous portal vein thrombosis and splenic vein thrombosis in a COVID-19 patient: A case report and review of literature., PMID:38983408
FRACTION: protocol of a phase II study of Fedratinib and Nivolumab combination in patients with myelofibrosis and resistance or suboptimal response to JAK-inhibitor treatment of the German MPN study group (GSG-MPN)., PMID:38967662
Knockdown of miR-155 alleviates skin damage in rats with chronic spontaneous urticaria by modulating the JAK/STAT signaling pathway., PMID:38951930
Interleukin-6 serves as a critical factor in various cancer progression and therapy., PMID:38900329
An in silico investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products., PMID:38833509
Role of autonomic nervous system in BDE-209 maternal exposure induced immunotoxicity in female offspring., PMID:38808594
Advances in Hodgkin Lymphoma Treatment: From Molecular Biology to Clinical Practice., PMID:38791909
The clonal hematopoiesis mutation Jak2V617F aggravates endothelial injury and thrombosis in arteries with erosion-like intimas., PMID:38759798
Spinal lipocalin 2 as a factor in the development of central post-stroke pain., PMID:38705557
Autoimmune myelofibrosis: A Mayo Clinic series of 22 patients., PMID:38698680
IL20Rb aggravates pulmonary fibrosis through enhancing bone marrow derived profibrotic macrophage activation., PMID:38583686
Effectiveness of tofacitinib monotherapy for patients with IgG4-RD or idiopathic retroperitoneal fibrosis., PMID:38530663
Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice., PMID:38526174
An in vitro study elucidating the synergistic effects of aqueous cinnamon extract and an anti-TNF-α biotherapeutic: implications for a complementary and alternative therapy for non-responders., PMID:38521924
For research use only. Not for human or drug use.
