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Anti-Durvalumab Polyclonal Antibody

Catalog #:   PAJ70101 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA
Accession: CAS: 1428935-60-7
Overview

Catalog No.

PAJ70101

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

Durvalumab

Tested applications

ELISA: 1:4000-1:8000

Target

Rabbit polyclonal antibody to Imfinzi.

Specificity

The product is specific for Durvalumab. This antibody serves as an excellent positive control for Durvalumab immunogenicity (ADA) assays.

Concentration

0.5 mg/ml

Purification

Purified by antigen affinity column.

Accession

CAS: 1428935-60-7

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.

Background

Durvalumab (Imfinzi) is a human IgG1 monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of cancer. It was developed by Medimmune/AstraZeneca. Durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody which blocks the interaction of PD-L1 with the PD-1 and CD80 molecules.Antibodysystem Anti-Durvalumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Durvalumab.

Data Image
References

Immune-mediated enterocolitis is associated with immune checkpoint inhibitors: A pharmacovigilance study from the FDA Adverse Event Reporting System (FAERS) database., PMID:40465755

Perioperative durvalumab plus chemotherapy plus new agents for resectable non-small-cell lung cancer: the platform phase 2 NeoCOAST-2 trial., PMID:40450142

Differential safety profiles of durvalumab monotherapy and durvalumab in combination with tremelimumab in adult patients with advanced cancers., PMID:40447320

Treatment of small cell lung cancer; advances and future prospects., PMID:40446464

[Complete Response Achieved by Gemcitabine+Cisplatin+Durvalumab Therapy for Lymph Node Recurrence of Intraductal Cholangiocarcinoma-A Case Report]., PMID:40420374

Adjuvant Immunotherapy in Microsatellite Instability-High Colon Cancer: A Literature Review on Efficacy, Challenges, and Future Directions., PMID:40415356

Real-world survival outcomes, treatment patterns, and impact of PD-L1 expression among patients with unresectable, stage III NSCLC treated with CRT → durvalumab in Canada: The RELEVANCE study., PMID:40393235

A platform for SpyCatcher conjugation to native antibodies., PMID:40386161

First-line durvalumab therapy alone or in combination with tremelimumab for metastatic head and neck squamous cell carcinoma: A cost-effectiveness analysis., PMID:40378108

A pharmacovigilance analysis of post-marketing safety of durvalumab., PMID:40360595

Equalizing prognostic disparities in KRAS-mutated stage III NSCLC patients: addition of durvalumab to combined chemoradiotherapy improves survival., PMID:40349418

Impact of durvalumab re-administration after moderate symptomatic pneumonitis in locally advanced non-small cell lung cancer., PMID:40349417

Real-world outcomes of subsequent treatment strategies after durvalumab consolidation in stage III unresectable non-small cell lung cancer., PMID:40347676

Carboplatin, etoposide, atezolizumab, and bevacizumab in the first-line treatment of patients with extensive stage small-cell lung cancer: the GOIRC-01-2019 CeLEBrATE study., PMID:40341031

Durvalumab with or without tremelimumab in combination with chemotherapy in first-line metastatic non-small-cell lung cancer: outcomes by tumor mutational burden in POSEIDON., PMID:40334315

Adverse events self-reported by patients with extensive-stage small-cell lung cancer in the phase III CASPIAN study., PMID:40331625

DOMENICA: dostarlimab versus chemotherapy alone in first-line MMR-deficient advanced endometrial cancer patients., PMID:40323277

Revisiting resectability of biliary tract cancers, in the triplet drug therapy era with immune checkpoint inhibitors., PMID:40314879

LAURA Completes the Osimertinib Treatment Jigsaw Puzzle of EGFR+ NSCLC from Stage IB to IV: Adjuvant Osimertinib Significantly Improves PFS and CNS Progression in Unresectable Stage III EGFR-Mutated NSCLC Compared to Placebo (LAURA, NCT03521154)., PMID:40313586

Multimodality treatment in synchronous oligometastatic NSCLC: Analysis of the ETOP CHESS trial., PMID:40311307

A phase II study of monalizumab and durvalumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: results of the I2 cohort of the EORTC-HNCG-1559 trial (UPSTREAM)., PMID:40311183

Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab., PMID:40311014

Tremelimumab plus durvalumab versus sorafenib in first-line treatment of unresectable hepatocellular carcinoma: a cost-effectiveness analysis from the US payer perspective., PMID:40306910

Durvalumab consolidation after chemoradiotherapy in unresectable stage III non-small cell lung cancer: A real-world experience from the Australian subset of PACIFIC-R., PMID:40300443

Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial., PMID:40298406

TROPION-Breast05: a randomized phase III study of Dato-DXd with or without durvalumab versus chemotherapy plus pembrolizumab in patients with PD-L1-high locally recurrent inoperable or metastatic triple-negative breast cancer., PMID:40297626

Conversion Surgery Performed Following Durvalumab Combined With Gemcitabine and Cisplatin in Cholangiocarcinoma: A Case Report., PMID:40294984

A phase I clinical trial of radiation therapy, durvalumab and tremelimumab in recurrent gynecologic cancer., PMID:40273550

Cost-effectiveness of perioperative nivolumab + neoadjuvant platinum doublet chemotherapy as treatment for resectable non-small cell lung cancer in the United States., PMID:40253592

Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review., PMID:40247987

Cardiological adverse events in hepatocellular carcinoma patients receiving immunotherapy: Influence of comorbidities and clinical outcomes., PMID:40245453

Pathological complete response following addition of durvalumab to gemcitabine and cisplatin therapy for intrahepatic cholangiocarcinoma with Lynch syndrome-associated mismatch repair deficiency., PMID:40210796

Factors affecting survival and prognosis in extensive stage small cell lung cancer., PMID:40200252

Comparing Durvalumab, Olaparib, and Cediranib Monotherapy, Combination Therapy, or Chemotherapy in Patients with Platinum-Resistant Ovarian Cancer with Prior Bevacizumab: The Phase II NRG-GY023 Trial., PMID:40192715

Evaluating the Efficacy and Safety of Durvalumab Plus Radiotherapy in Second-Line Treatment for Advanced Bladder Cancer., PMID:40191869

Early insulin averts hyperglycemic crisis in slow-onset durvalumab-induced checkpoint inhibitor-associated autoimmune diabetes mellitus., PMID:40182155

PD-L1 expression in multiple myeloma myeloid derived suppressor cells., PMID:40180451

Mid-term Combination Immunotherapy and its Effect on the Albumin-Bilirubin Score in Unresectable Hepatocellular Carcinoma., PMID:40155043

Advanced intrahepatic cholangiocarcinoma successfully treated with combined immunotherapy: focusing on the tumor immune microenvironment., PMID:40153223

A phase 1 study of durvalumab as monotherapy or combined with tremelimumab with or without azacitidine in patients with myelodysplastic syndrome., PMID:40153010

Immunoscore Predicted by Dynamic Contrast-Enhanced Computed Tomography Can Be a Non-Invasive Biomarker for Immunotherapy Susceptibility of Hepatocellular Carcinoma., PMID:40149284

Immune Checkpoint Inhibitor-associated Pneumonitis: A Narrative Review., PMID:40145913

Prompt initiation of durvalumab and tremelimumab for unresectable hepatocellular carcinoma in patients with chronic active hepatitis B: a phase 2 clinical trial., PMID:40128285

Completion Rates for Patients Undergoing Concurrent Chemoradiotherapy for Stage III Nonsmall Cell Lung Cancer and its Importance in the Era of Consolidation Immunotherapy: A Cohort Study., PMID:40113513

Immune-related adverse events are associated with better event-free survival in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage triple-negative breast cancer., PMID:40107153

Current and future perspectives in extensive-stage small-cell lung cancer., PMID:40093978

Epigenetic therapy sensitizes anti-PD-1 refractory head and neck cancers to immunotherapy rechallenge., PMID:40091844

A new standard for HCC: The high stakes of TACE-immunotherapy combinations., PMID:40088884

The evolving landscape of stage III unresectable non-small cell lung cancer "between lights and shadows"., PMID:40086102

Phase 2 study of neoadjuvant durvalumab plus docetaxel, oxaliplatin, and S-1 with surgery and adjuvant durvalumab plus S-1 for resectable locally advanced gastric cancer., PMID:40081945

Datasheet
$ 354
Product specifications
50 μg 354 100 μg 680

Contact Information

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Mail: support@antibodysystem.com

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For research use only. Not for human or drug use.

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Anti-Durvalumab Polyclonal Antibody [PAJ70101]
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