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Anti-Sarilumab Polyclonal Antibody

Catalog #:   PAC36901 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA
Accession: CAS: 1189541-98-7
Overview

Catalog No.

PAC36901

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

Sarilumab

Tested applications

ELISA: 1:4000-1:8000

Target

Rabbit polyclonal to Kevzara.

Specificity

The product is specific for Sarilumab. This antibody serves as an excellent positive control for Sarilumab immunogenicity (ADA) assays.

Concentration

0.5 mg/ml

Purification

Purified by antigen affinity column.

Accession

CAS: 1189541-98-7

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.

Background

Sarilumab with the trade name of Kevzara, is a human monoclonal IgG1 antibody. It binds to membrane bound and soluble interleukin 6 (IL-6) receptor forms. It was FDA-approved in for the treatment of Rheumatoid Arthritis (RA) in combination with methotrexate.

Data Image
References

Comparative effectiveness of subcutaneous sarilumab 200 mg biweekly, subcutaneous Tocilizumab 162 mg biweekly, and intravenous Tocilizumab 8 mg/kg every 4 weeks in patients with rheumatoid arthritis: a prospective cohort study., PMID:40055759

Interleukin 6 inhibition in refractory antisynthetase syndrome: case-based literature review., PMID:40053413

Long-term safety and efficacy of anti-GM-CSF otilimab in patients with rheumatoid arthritis: long-term extension of three phase 3 randomised trials (contRAst X)., PMID:40044198

Nontraumatic terminal ileal perforation in a patient with resistant palindromic rheumatism treated with sarilumab: A case report., PMID:40024808

Effectiveness of baricitinib versus sarilumab on disease activity in patients with RA: a propensity score matching study., PMID:39959132

Successful Remission of Refractory Rheumatoid Pleural Effusion and Arthritis Using Sarilumab: A Case Report., PMID:39744302

Long-term efficacy of sarilumab on the progression of interstitial lung disease in rheumatoid arthritis: the KEIO-RA cohort and literature review., PMID:39711360

Rates of glucocorticoid taper in the management of polymyalgia rheumatica: the science behind the "art"., PMID:39641835

A Glimpse for the subsistence from pandemic SARS-CoV-2 infection., PMID:39603070

Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies., PMID:39563277

Investigating the impact of Tocilizumab, Sarilumab, and Anakinra on clinical outcomes in COVID-19: A systematic review and meta-analysis., PMID:39221116

[Polymyalgia rheumatica: What's new?]., PMID:39146754

Use of interleukin-6 receptor antibodies in the second and third trimester of pregnancy: a retrospective cohort study., PMID:39116898

Newer Therapies in Rheumatology., PMID:39084836

The effects of sarilumab as monotherapy and in combination with non-methotrexate disease-modifying anti-rheumatic drugs on unacceptable pain in patients with rheumatoid arthritis: A post-hoc analysis of the HARUKA phase 3 study., PMID:39073577

Efficacy and safety of sarilumab in patients with rheumatoid arthritis stratified by age (<65 and ≥65 years): A post hoc analysis of Japanese Phase 3 clinical trials., PMID:39073574

Assessment of adverse events related to anti-interleukin-6 receptor monoclonal antibodies using the FDA adverse event reporting system: a real-world pharmacovigilance study., PMID:39049740

Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized COVID-19 patients., PMID:39028068

Safety of sarilumab in a Japanese population with rheumatoid arthritis by age group: Data from an interim analysis of a postmarketing surveillance study., PMID:38804962

Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection., PMID:38795859

Late Tuberculosis Reactivation After Severe Covid-19., PMID:38715882

Sarilumab (Kevzara) for polymyalgia rheumatica., PMID:38696312

Cancer risk with tocilizumab/sarilumab, abatacept and rituximab treatment in patients with rheumatoid arthritis: a Danish cohort study., PMID:38452297

Structural insights into IL-6 signaling inhibition by therapeutic antibodies., PMID:38393945

[Sarilumab for polymyalgia rheumatica]., PMID:38240818

Two cases of dermatomyositis associated with neuroendocrine tumors., PMID:38187177

Effectiveness and safety of sarilumab in patients with rheumatoid arthritis: A multicenter, retrospective, inverse probability of treatment-weighted analysis based on the FRAB-registry., PMID:38182801

Treatment experiences with focus on IL-6R inhibition in patients with VEXAS syndrome and a case of remission with azacytidine treatment., PMID:38141211

Efficacy of pharmacological interventions: a systematic review informing the 2023 EULAR recommendations for the management of fatigue in people with inflammatory rheumatic and musculoskeletal diseases., PMID:38056919

Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis: What Have We Learned?, PMID:37989892

Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper., PMID:37792612

Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)., PMID:37696589

Effect of sarilumab on unacceptable pain and inflammation control in Japanese patients with moderately-to-severely active rheumatoid arthritis: Post hoc analysis of a Phase III study (KAKEHASI)., PMID:37606691

Real-World Data of Adherence and Drug Survival of Biologics in Treatment-Naïve and Treatment-experienced Adult Patients with Rheumatoid Arthritis., PMID:37566157

A double-blind, placebo-controlled, randomized withdrawal trial of sarilumab for the treatment of glucocorticoid-dependent sarcoidosis., PMID:37471590

Real-World Sarilumab Use and Rule Testing to Predict Treatment Response in Patients with Rheumatoid Arthritis: Findings from the RISE Registry., PMID:37349636

Selective immune suppression using interleukin-6 receptor inhibitors for management of immune-related adverse events., PMID:37328287

Safety and effectiveness of sarilumab in Japanese patients with rheumatoid arthritis refractory to previous treatments: An interim analysis of a post-marketing surveillance., PMID:37300807

Sarilumab (interleukin-6 receptor monoclonal antibody) for the treatment of pemphigus vulgaris., PMID:37146158

Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients., PMID:37055774

Improvement or Worsening of Disease Activity After Switch to Sarilumab in Patients With Rheumatoid Arthritis With a Partial Response to Adalimumab., PMID:36858816

Long-term safety and efficacy of sarilumab with or without background csDMARDs in rheumatoid arthritis., PMID:36727470

Comparison of the efficacy and safety of tocilizumab, sarilumab, and olokizumab in patients with active rheumatoid arthritis: a network meta-analysis of randomized controlled trials., PMID:36607422

Disproportionate articular pain is a frequent phenomenon in rheumatoid arthritis and responds to treatment with sarilumab., PMID:36413080

Fetal and Neonatal Adverse Drug Reactions Associated with Biologics Taken During Pregnancy by Women with Autoimmune Diseases: Insights from an Analysis of the World Health Organization Pharmacovigilance Database (VigiBase®)., PMID:36401769

Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients: An updated network meta-analysis of 48 randomized controlled trials., PMID:36254081

Care for adults with COVID-19: living guidelines from the National COVID-19 Clinical Evidence Taskforce., PMID:36150213

Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors., PMID:36148395

Immune-related adverse events of biological immunotherapies used in COVID-19., PMID:36091800

Pediatric rheumatologists' perspectives on diagnosis, treatment, and outcomes of Sjögren disease in children and adolescents., PMID:36064423

Datasheet
$ 354
Product specifications
50 μg 354 100 μg 680

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Anti-Sarilumab Polyclonal Antibody [PAC36901]
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