Catalog No.
PHA69201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TNFSF12 (Asp65-Gln247).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TWEAK,DR3LG,TNFSF12,Tumor necrosis factor ligand superfamily member 12,APO3L,TNF-related weak inducer of apoptosis,APO3 ligand
Purification
Purified by antigen affinity column.
Accession
O43508
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
TWEAK increases angiogenesis to promote diabetic skin wound healing by regulating Fn14/EGFR signaling., PMID:39166480
Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury., PMID:38007933
TNF-like weak inducer of apoptosis inhibition is comparable to IL-13 blockade in ameliorating atopic dermatitis inflammation., PMID:37650473
Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel., PMID:34945004
TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy., PMID:34797693
Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI., PMID:34646379
TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease., PMID:34155062
Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation., PMID:32979359
Serum and urine TNF-like weak inducer of apoptosis, monocyte chemoattractant protein-1 and neutrophil gelatinase-associated lipocalin as biomarkers of disease activity in patients with systemic lupus erythematosus., PMID:32041504
MicroRNA-889 Inhibits Autophagy To Maintain Mycobacterial Survival in Patients with Latent Tuberculosis Infection by Targeting TWEAK., PMID:31992621
Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis., PMID:31885495
The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock., PMID:31679818
Changes in serum TNF-like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti-TNF treatments., PMID:31531981
A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis., PMID:31395500
Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts., PMID:30576385
Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study., PMID:29668584
Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults., PMID:29548604
Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells., PMID:29075649
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review., PMID:29065901
TWEAK/Fn14 signaling in tumors., PMID:28639899
Role of the tumour necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in autoimmune thyroid disease., PMID:28636775
Advanced glycation end products attenuate the function of tumor necrosis factor-like weak inducer of apoptosis to regulate the inflammatory response., PMID:28455790
TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice., PMID:28447667
Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice., PMID:28428709
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases., PMID:28275260
Systemic lupus erythematosus biomarkers: the challenging quest., PMID:28013203
Roles of tumour necrosis factor-related weak inducer of apoptosis/fibroblast growth factor-inducible 14 pathway in lupus nephritis., PMID:27786399
The role of soluble tumor necrosis factor like weak inducer of apoptosis and interleukin-17A in the etiopathogenesis of celiac disease: A cross-sectional study., PMID:27367991
Out of the TWEAKlight: Elucidating the Role of Fn14 and TWEAK in Acute Kidney Injury., PMID:27339384
TWEAK-binding autoantibodies are generated during psoriatic arthritis and are not influenced by anti-TNF therapy., PMID:27338143
Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108
Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway., PMID:27098560
TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease., PMID:27026366
Population pharmacokinetic and pharmacodynamic analysis of BIIB023, an anti-TNF-like weak inducer of apoptosis (anti-TWEAK) monoclonal antibody., PMID:26896828
The role of circulating sTWEAK in the pathogenesis of Hashimoto's thyroiditis - a pilot study., PMID:26884302
The role of TWEAK/Fn14 signaling in the MPTP-model of Parkinson's disease., PMID:26808775
Towards new avenues in the management of lupus glomerulonephritis., PMID:26729459
The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury., PMID:26535995
Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors., PMID:26446946
Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival., PMID:26359988
Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD., PMID:26012567
TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice., PMID:25911200
Elevated Serum Levels of Soluble CD163 in Polymyositis and Dermatomyositis: Associated with Macrophage Infiltration in Muscle Tissue., PMID:25877505
Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis., PMID:25765661
TWEAK and NT-proBNP levels predict exercise capacity in hypertrophic cardiomyopathy., PMID:25524713
TWEAK/Fn14, a pathway and novel therapeutic target in myotonic dystrophy., PMID:25504044
Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis., PMID:25270074
Pathological activation of canonical nuclear-factor κB by synergy of tumor necrosis factor α and TNF-like weak inducer of apoptosis in mouse acute colitis., PMID:25022957
TNF-like weak inducer of apoptosis aggravates left ventricular dysfunction after myocardial infarction in mice., PMID:24692845
TWEAK and the progression of renal disease: clinical translation., PMID:24493870
For research use only. Not for human or drug use.
