Catalog No.
DHG26701
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
Tetherin, Bone marrow stromal antigen 2, BST2, BST-2, CD317, HM1.24 antigen
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q10589
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
XmAb-5592, XmAb 5592, XmAb5592
Clone ID
XmAb 5592
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers., PMID:39718725
Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin., PMID:38190411
Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin., PMID:37858466
Chimeric antigen receptor T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastoma., PMID:37335916
The roles of BST-2 in murine B cell development and on virus propagation., PMID:36604771
OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver., PMID:36602064
Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients., PMID:35081977
Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells., PMID:34890590
Plasmacytoid dendritic cells promote the pathogenesis of Sjögren's syndrome., PMID:34780913
CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity., PMID:33785592
A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma., PMID:33753855
Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis., PMID:33150680
CD319 (SLAMF7) an alternative marker for detecting plasma cells in the presence of daratumumab or elotuzumab., PMID:33017079
Antibody development and property analysis of RhBST2 for accurate cell biological and viral research., PMID:32681953
The Nef Protein of the Macrophage Tropic HIV-1 Strain AD8 Counteracts Human BST-2/Tetherin., PMID:32325729
Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection., PMID:31824485
pDC depletion induced by CD317 blockade drives the antitumor immune response in head and neck squamous cell carcinoma., PMID:31422204
Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses., PMID:31213558
CD317 Activates EGFR by Regulating Its Association with Lipid Rafts., PMID:30890618
Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner., PMID:30759394
Aberrant expression of the innate restriction factor bone marrow stromal antigen-2 in primary Sjögren's syndrome., PMID:30249485
Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice., PMID:30219230
T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool., PMID:30201960
CD317 Signature in Head and Neck Cancer Indicates Poor Prognosis., PMID:29486141
Single-cell analysis identifies cellular markers of the HIV permissive cell., PMID:29073251
BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity., PMID:28331088
Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies., PMID:27853288
The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies., PMID:27707924
Tetherin Antagonism by HIV-1 Group M Nef Proteins., PMID:27654287
Monoclonal Antibody Against Bone Marrow Stromal Cell Antigen 2 Protein of Swine., PMID:27328062
Tetherin/BST-2: Restriction Factor or Immunomodulator?, PMID:26957198
CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody., PMID:26498112
Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors., PMID:26317613
Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge., PMID:26311886
Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity., PMID:26269175
Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes., PMID:25907558
The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA' enables screening of antibodies for immunotoxin development., PMID:25701195
The role of HIV-specific antibody-dependent cellular cytotoxicity in HIV prevention and the influence of the HIV-1 Vpu protein., PMID:25396265
Targeted therapy for HM1.24 (CD317) on multiple myeloma cells., PMID:25143955
The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells., PMID:24927408
Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity., PMID:24733916
HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells., PMID:24623433
HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2., PMID:24498878
Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors., PMID:24386306
Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities., PMID:23786957
Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo., PMID:23185591
Characterization of 5C11-positive activated interferon-producing cells in patients with systemic lupus erythematosus., PMID:23087259
Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer., PMID:22729361
Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function., PMID:22246035
Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction., PMID:22194693
For research use only. Not for human or drug use.
