Catalog No.
DHF68801
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
TACE, Snake venom-like protease, ADAM17, CD156b, CSVP, ADAM 17, Disintegrin and metalloproteinase domain-containing protein 17, TNF-alpha convertase, TNF-alpha-converting enzyme
Concentration
3.1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P78536
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MEDI3622
Clone ID
MEDI3622
Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex., PMID:40512800
The role of EphA2 in ADAM17- and ionizing radiation-enhanced lung cancer cell migration., PMID:36998455
An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model., PMID:35757773
The ADAM17-directed Inhibitory Antibody MEDI3622 Antagonizes Radiotherapy-induced VEGF Release and Sensitizes Non-Small Cell Lung Cancer for Radiotherapy., PMID:36860547
Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils., PMID:33264689
Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis., PMID:32932701
Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells., PMID:29978334
Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency., PMID:29029414
Molecular basis for the mechanism of action of an anti-TACE antibody., PMID:27610476
A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways., PMID:25948294
For research use only. Not for human or drug use.
