Catalog No.
RHH20001
Species reactivity
Human, Mouse, Rat, Bovine, Sumatran orangutan, Zebrafish
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Mothers against decapentaplegic homolog 2, SMAD 2, SMAD2, JV18-1, Mad-related protein 2, hMAD-2, MADR2, Mothers against DPP homolog 2, SMAD family member 2, MADH2, Smad2, hSMAD2, MAD homolog 2
Concentration
1.98 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q15796
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
P4.B9
Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L., PMID:36093806
Endothelin-1 Induced Phosphorylation of Caveolin-1 and Smad2C in Human Vascular Smooth Muscle Cells: Role of NADPH Oxidases, c-Abl, and Caveolae Integrity in TGF-β Receptor Transactivation., PMID:37727643
Endoplasmic reticulum stress inhibits 3D Matrigel-induced vasculogenic mimicry of breast cancer cells via TGF-β1/Smad2/3 and β-catenin signaling., PMID:34320274
Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity., PMID:33577554
Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals., PMID:32133888
Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation., PMID:31290007
KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27., PMID:30786277
Reactive Oxygen Species and p38MAPK Have a Role in the Smad2 Linker Region Phosphorylation Induced by TGF-β., PMID:30046209
Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β., PMID:25707005
A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer., PMID:23993964
HRG-β1-driven ErbB3 signaling induces epithelial-mesenchymal transition in breast cancer cells., PMID:23937725
Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque., PMID:23770939
Smad7 foci are present in micronuclei induced by heavy particle radiation., PMID:23643526
Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition., PMID:23624917
IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects., PMID:23572226
Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis., PMID:23238123
TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity., PMID:21791611
Increased cavernous expression of transforming growth factor-β1 and activation of the Smad signaling pathway affects erectile dysfunction in men with spinal cord injury., PMID:20946170
Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats., PMID:20854076
Transforming growth factor (TGF)-β type I receptor kinase (ALK5) inhibitor alleviates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque., PMID:20233292
Palifermin induces alveolar maintenance programs in emphysematous mice., PMID:20007933
Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling., PMID:19351925
Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts., PMID:19171760
Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium., PMID:19081766
Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation., PMID:19038005
Role of increased penile expression of transforming growth factor-beta1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats., PMID:18778311
Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8., PMID:18312428
A sensitive detection of phospho-Smad1/5/8 and Smad2 in Western blot analyses., PMID:17976733
Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo., PMID:17878288
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells., PMID:17638924
TGF-beta-neutralizing antibodies improve pulmonary alveologenesis and vasculogenesis in the injured newborn lung., PMID:17400601
Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1., PMID:16849548
The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells., PMID:16818503
Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct., PMID:16643884
Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism., PMID:15734860
BMP and activin receptor expression in lens development., PMID:15346106
Acute allergen-induced airway remodeling in atopic asthma., PMID:15333330
Profile of transforming growth factor-beta responses during the murine hair cycle., PMID:14708594
Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma., PMID:12839562
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development., PMID:10851136
For research use only. Not for human or drug use.
