Catalog No.
RHD25201
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Applications
IF, WB
Target
5,6-dihydroxyindole-2-carboxylic acid oxidase, Glycoprotein 75, CAS2, TYRP1, TRP-1, TYRRP, TRP1, Catalase B, TYRP, Melanoma antigen gp75, TRP, DHICA oxidase, Tyrosinase-related protein 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P17643
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
TA99
Note
For research use only.
Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA., PMID:11564171
The role of phosphoinositide 3-kinase in the sorting and transport of newly synthesized tyrosinase-related protein-1 (TRP-1)., PMID:11764278
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase., PMID:11775059
The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase., PMID:12028586
Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo., PMID:12121667
Induction of autoantibodies against tyrosinase-related proteins following DNA vaccination: unexpected reactivity to a protein paralogue., PMID:12747753
Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1., PMID:14623273
Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment., PMID:15096515
Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes., PMID:16040064
The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers., PMID:16682408
Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage., PMID:18055784
Dependency of intraocular pressure elevation and glaucomatous changes in DBA/2J and DBA/2J-Rj mice., PMID:18235006
Tumor endothelial marker 8 enhances tumor immunity in conjunction with immunization against differentiation Ag., PMID:18236207
RHEB expression in fibroadenomas of the breast., PMID:18324915
Generation and characterization of a therapeutic human antibody to melanoma antigen TYRP1., PMID:18334748
Enhanced suppression of melanoma tumor growth and metastasis by combined therapy with anti-VEGF receptor and anti-TYRP-1/gp75 monoclonal antibodies., PMID:19035294
Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma., PMID:19047169
CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection., PMID:19276379
The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas., PMID:19287070
Immune rejection of mouse tumors expressing mutated self., PMID:19351857
Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosinase-related protein 1 and generates antitumor immunity in mice., PMID:19414747
GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1., PMID:20668223
Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma., PMID:21324755
Aire deficiency promotes TRP-1-specific immune rejection of melanoma., PMID:23370329
Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice., PMID:24613852
Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology., PMID:24880201
Hyperosmotic stress reduces melanin production by altering melanosome formation., PMID:25170965
An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen., PMID:25875653
A large insertion in intron 2 of the TYRP1 gene associated with American Palomino phenotype in American mink., PMID:26886941
Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection., PMID:27193292
CRISPR/Cas9 Targets Chicken Embryonic Somatic Cells In Vitro and In Vivo and generates Phenotypic Abnormalities., PMID:27694906
An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma., PMID:27797971
Spontaneous generation of a novel foetal human retinal pigment epithelium (RPE) cell line available for investigation on phagocytosis and morphogenesis., PMID:28924976
Antigen-specificity of antiretinal antibodies in patients with noninfectious uveitis., PMID:28985805
High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy., PMID:30397036
Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin., PMID:30543899
Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients., PMID:30786924
Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine., PMID:32088020
Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice., PMID:33084421
Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma., PMID:33520112
Characterization of Immune Infiltration and Construction of a Prediction Model for Overall Survival in Melanoma Patients., PMID:33869027
Comparison of tyrosinase antibody, tyrosinase-related protein-1 and -2 antibodies, melanin-concentrating hormone receptor antibody levels with autologous serum skin test and autologous plasma skin test results in patients with vitiligo., PMID:34377130
Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo., PMID:34854998
GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells., PMID:35011407
Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1., PMID:36207642
Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics., PMID:37050035
Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma., PMID:37208128
Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG., PMID:37593202
Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure., PMID:38577337
TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models., PMID:39308793
For research use only. Not for human or drug use.
