Anti-ISLR Polyclonal Antibody

Catalog No.

PHA20001

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ISLR (Cys19-Phe428).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

ISLR,Immunoglobulin superfamily containing leucine-rich repeat protein

Purification

Purified by antigen affinity column.

Accession

O14498

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis., PMID:39136356

Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity by Suppressing Pyruvate Kinase Isozyme M2 Activity., PMID:38786060

Toward harmonized interpretation of anticardiolipin and anti-β2-glycoprotein I antibody detection for diagnosis of antiphospholipid syndrome using defined level intervals and likelihood ratios: communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies., PMID:38704123

Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis., PMID:36077405

Silencing of immunoglobulin superfamily containing leucine-rich repeat inhibits gastric cancer cell growth and metastasis by regulating epithelial-mesenchymal transition., PMID:35653801

CNN-LSTM Hybrid Real-Time IoT-Based Cognitive Approaches for ISLR with WebRTC: Auditory Impaired Assistive Technology., PMID:35237390

Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma., PMID:35209871

Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer., PMID:34713300

ISLR affects colon cancer progression by regulating the epithelial-mesenchymal transition signaling pathway., PMID:34520435

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity., PMID:33960573

Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue., PMID:33760832

The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., PMID:33197448

Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma., PMID:32705221

ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway., PMID:32696215

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling., PMID:32128839

Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis., PMID:31439548

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction., PMID:31221024

Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy., PMID:30510196

A novel ISLR2-linked autosomal recessive syndrome of congenital hydrocephalus, arthrogryposis and abdominal distension., PMID:30483960

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells., PMID:26924503

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo., PMID:18848646

Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling., PMID:11832495

Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression., PMID:10512678

Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)., PMID:9325048

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