Catalog No.
PHA17001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CCN1 (Leu178-Asp381).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Insulin-like growth factor-binding protein 10,Protein GIG1,IGF-binding protein 10,CYR61,Cellular communication network factor 1,IBP-10,Cysteine-rich angiogenic inducer 61,GIG1,Protein CYR61,CCN1,IGFBP-10,IGFBP10,CCN family member 1
Purification
Purified by antigen affinity column.
Accession
O00622
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CYR61 as a Potential Biomarker and Target in Cancer Prognosis and Therapies., PMID:40497940
HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy., PMID:36418932
CCN1 upregulates IL-36 via AKT/NF-κB and ERK/CEBP β-mediated signaling pathways in psoriasis-like models., PMID:36376243
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes., PMID:35038159
ZNF213 negatively controls triple negative breast cancer progression via Hippo/YAP signaling., PMID:33939216
Cyr61 synthesis is induced by interleukin-6 and promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis., PMID:33228785
Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms., PMID:32818017
Cyr61 Promotes Inflammation of a Gouty Arthritis Model in Rats., PMID:32774151
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis., PMID:32622876
Pro-metastatic functions of Notch signaling is mediated by CYR61 in breast cells., PMID:32005345
CCN1 stimulated the osteoblasts via PTEN/AKT/GSK3β/cyclinD1 signal pathway in Myeloma Bone Disease., PMID:31769620
A Novel Electrochemiluminescent Immunoassay Based on Target Transformation Assisted with Catalyzed Hairpin Assembly Amplification for the Ultrasensitive Bioassay., PMID:31365231
Oncolytic Herpes Virus Armed with Vasculostatin in Combination with Bevacizumab Abrogates Glioma Invasion via the CCN1 and AKT Signaling Pathways., PMID:31092561
CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process., PMID:30642298
CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis., PMID:30347516
Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation., PMID:30262666
Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9., PMID:28608634
The profile of Cyr61 expression data correlate to the skin inflammation in psoriasis., PMID:28054013
Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway., PMID:27856305
CYR61 suppresses growth of human malignant melanoma., PMID:27665942
Cyr61 participates in the pathogenesis of rheumatoid arthritis via promoting MMP-3 expression by fibroblast-like synoviocytes., PMID:27585710
CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation., PMID:27482114
Liver Fibrosis: From Pathogenesis to Novel Therapies., PMID:27170396
Invasion and increased expression of S100A4 and CYR61 in mesenchymal transformed breast cancer cells is downregulated by GnRH., PMID:27098123
Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression., PMID:26630293
The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression., PMID:26625209
CCN1 acutely increases nitric oxide production via integrin αvβ3-Akt-S6K-phosphorylation of endothelial nitric oxide synthase at the serine 1177 signaling axis., PMID:26393424
The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing., PMID:26077348
Serum Cyr61 is associated with clinical disease activity and inflammation in patients with systemic lupus erythematosus., PMID:25984669
Cyr61 as mediator of Src signaling in triple negative breast cancer cells., PMID:25980494
The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6., PMID:25807183
Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion., PMID:25783840
Involvement of cysteine-rich protein 61 in the epidermal growth factor-induced migration of human anaplastic thyroid cancer cells., PMID:25773758
Effects of CCN1 and Macrophage Content on Glioma Virotherapy: A Mathematical Model., PMID:25758754
CCN1 induces oncostatin M production in osteoblasts via integrin-dependent signal pathways., PMID:25187949
Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway., PMID:25187756
Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury., PMID:24920753
CCN1 secreted by tonsil-derived mesenchymal stem cells promotes endothelial cell angiogenesis via integrin αv β3 and AMPK., PMID:24909560
Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance., PMID:24895995
Pancreatic tumor cell secreted CCN1/Cyr61 promotes endothelial cell migration and aberrant neovascularization., PMID:24833309
Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis., PMID:24517278
Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration., PMID:24371135
Interaction of CCN1 with αvβ3 integrin induces P-glycoprotein and confers vinblastine resistance in renal cell carcinoma cells., PMID:23744557
A novel anti-CCN1 monoclonal antibody suppresses Rac-dependent cytoskeletal reorganization and migratory activities in breast cancer cells., PMID:23618859
Coating decellularized equine carotid arteries with CCN1 improves cellular repopulation, local biocompatibility, and immune response in sheep., PMID:23521030
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury., PMID:23316072
CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion., PMID:23313051
[Promoting effects of CYR61 on proliferation, migration and tube formation of choroid-retinal endothelial cells]., PMID:22943867
Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells., PMID:22253074
Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy., PMID:22160564
For research use only. Not for human or drug use.
