Catalog No.
PHA12601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TRAF5 (Gln181-Arg437).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TRAF5,RNF84,TNF receptor-associated factor 5,RING finger protein 84
Purification
Purified by antigen affinity column.
Accession
O00463
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
The Role of TNF Receptor-Associated Factor 5 in the Formation of Germinal Centers by B Cells During the Primary Phase of the Immune Response in Mice., PMID:39596396
An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression., PMID:37473759
IL-17A neutralizing antibody attenuates eosinophilic meningitis caused by Angiostrongylus cantonensis by involving IL-17RA/Traf6/NF-κB signaling., PMID:31415761
TRAF5 negatively regulates TLR signaling in B lymphocytes., PMID:24259503
TNF receptor-associated factor 5 gene confers genetic predisposition to acute anterior uveitis and pediatric uveitis., PMID:24020968
Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction., PMID:23413803
T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy., PMID:22017440
TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40., PMID:19805155
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma., PMID:16953224
Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis., PMID:15914563
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway., PMID:12842894
The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death., PMID:12566458
CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line., PMID:12220533
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals., PMID:11867568
Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells., PMID:11144929
Immune regulation by CD40-CD40-l interactions - 2; Y2K update., PMID:11056083
CD40-mediated activation of Ig-Cgamma1- and Ig-cepsilon germ-line promoters involves multiple TRAF family proteins., PMID:10601998
Frequent expression of the variant CD30 in human malignant myeloid and lymphoid neoplasms., PMID:10595933
An 11-amino acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun N-terminal kinase, activation of MAPKAP kinase-2, phosphorylation of I kappa B alpha, and protection of WEHI-231 cells from anti-IgM-induced growth arrest., PMID:10202013
For research use only. Not for human or drug use.
