Anti-PLK4 Polyclonal Antibody

Catalog No.

PHA11801

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PLK4 (Met1-Pro263).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

PLK-4,Serine/threonine-protein kinase Sak,Serine/threonine-protein kinase PLK4,STK18,PLK4,Polo-like kinase 4,Serine/threonine-protein kinase 18,SAK

Purification

Purified by antigen affinity column.

Accession

O00444

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Cadmium promotes the binding and centrosomal translocation of CCDC85C and PLK4 via ROS-GCLM pathway to trigger centrosome amplification in colon cancer cells., PMID:38185225

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML., PMID:37738460

Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles., PMID:37654580

Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer., PMID:32255253

Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors., PMID:31506528

Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays., PMID:29468550

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton., PMID:27872092

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer., PMID:26832928

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly., PMID:26101219

Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification., PMID:25590559

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152., PMID:24277814

Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease., PMID:23300604

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes., PMID:23213374

CENP-C is a structural platform for kinetochore assembly., PMID:21353555

Polo-box domains confer target specificity to the Polo-like kinase family., PMID:18359294

Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles., PMID:18320067

Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase., PMID:11489907

Sak 57, an intermediate filament keratin present in intercellular bridges of rat primary spermatocytes., PMID:8873075

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Anti-PLK4 Polyclonal Antibody.pdf