Catalog No.
FMD41010
Species reactivity
Mouse
Host species
Rat
Isotype
IgG2b
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P24063
Applications
FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
FD441.8
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance., PMID:40512837
MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases., PMID:40312574
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806
Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer., PMID:39082930
Flow cytometric immunophenotypic differentiation patterns of bone marrow eosinophilopoiesis., PMID:38666394
ValCitGlyPro-dexamethasone antibody conjugates selectively suppress the activation of human monocytes., PMID:37974960
Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis., PMID:37752582
Analysis of Novel Immunological Biomarkers Related to Rheumatoid Arthritis Disease Severity., PMID:37569732
Trail Formation Alleviates Excessive Adhesion and Maintains Efficient Neutrophil Migration., PMID:36976830
Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15., PMID:36944397
Allosteric targeting resolves limitations of earlier LFA-1 directed modalities., PMID:36921634
Phenotyping and Genotyping of HNA: Prevalence, Risk of Alloimmunization, and HNA Incompatibilities in Indians., PMID:36818775
Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis., PMID:36810163
Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction., PMID:36369367
Immune cell composition of the bronchoalveolar lavage fluid in healthy and respiratory diseased dromedary camels., PMID:36131278
Flow Cytometric Analysis of Leukocyte Populations in the Lung Tissue of Dromedary Camels., PMID:35737339
The Impact of Anticoagulation Agent on the Composition and Phenotype of Blood Leukocytes in Dromedary Camels., PMID:35202331
3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation., PMID:35001849
Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells., PMID:34368126
RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth., PMID:34043012
β2 Integrin Signaling Cascade in Neutrophils: More Than a Single Function., PMID:33679708
Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1., PMID:33462305
Systemic Delivery of Anti-Integrin αL Antibodies Reduces Early Macrophage Recruitment, Inflammation, and Scar Formation in Murine Burn Wounds., PMID:33124967
Human neutrophil antigens: Nature, clinical significance and detection., PMID:32970372
Dromedary camel CD14high MHCIIhigh monocytes display inflammatory properties and are reduced in newborn camel calves., PMID:32070351
Rat IgG mediated circulatory cell depletion in mice requires mononuclear phagocyte system and is facilitated by complement., PMID:31965640
Determination of CD Markers Profile of the Cell Line Infected by S15 Vaccine Strain of Theileria annulata Schizont Using RT-PCR Analysis., PMID:31939260
Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers., PMID:31447833
TGF-β enhances the cytotoxic activity of Vδ2 T cells., PMID:30546961
Effects of RNA interference-mediated E-selectin gene silencing on cell adhesion molecule expression and cell-cell adhesion in vascular endothelial cells in mice with immunologic contact urticaria., PMID:30206961
OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites., PMID:30073152
Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay., PMID:30053831
Similar Inhibition of Dynamic Adhesion of Lymphocytes From IBD Patients to MAdCAM-1 by Vedolizumab and Etrolizumab-s., PMID:29788362
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors)., PMID:29427804
Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism., PMID:29197072
Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules., PMID:29042015
Reactivity of commercially available monoclonal antibodies to human CD antigens with peripheral blood leucocytes of dromedary camels (Camelus dromedarius)., PMID:28652982
CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes., PMID:28611472
Mutation characterization and heterodimer analysis of patients with leukocyte adhesion deficiency: Including one novel mutation., PMID:28445705
Characterisation of monoclonal antibodies specific for hamster leukocyte differentiation molecules., PMID:28063475
IL-20 promotes epithelial healing of the injured mouse cornea., PMID:27818315
Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate., PMID:27731313
Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction., PMID:27570549
Leukocyte adhesion molecule dynamics after Natalizumab withdrawal in Multiple Sclerosis., PMID:27496090
Identification of Stage-Specific Surface Markers in Early B Cell Development Provides Novel Tools for Identification of Progenitor Populations., PMID:27456481
Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism., PMID:27378825
Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry., PMID:27260809
Brief Report: HIV-1 Infection Impairs CD16 and CD35 Mediated Opsonophagocytosis of Mycobacterium tuberculosis by Human Neutrophils., PMID:27258232
For research use only. Not for human or drug use.
