Catalog No.
PHA08601
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TNFRSF11B (Thr76-Lys317).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,OCIF
Purification
Purified by antigen affinity column.
Accession
O00300
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
[Correlation of RANKL/OPG, dickkopf-1 and bone marrow edema in rheumatoid arthritis with the complaint of knee pain]., PMID:25924445
Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts., PMID:25956608
Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion., PMID:25978399
Characterisation of osteoprotegerin autoantibodies in coeliac disease., PMID:26092508
Osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as prognostic factors in rheumatoid arthritis: results from the ESPOIR cohort., PMID:26220665
Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy., PMID:26364678
RANKL/RANK interaction promotes the growth of cervical cancer cells by strengthening the dialogue between cervical cancer cells and regulation of IL-8 secretion., PMID:26398902
Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-α., PMID:26856585
Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-κB ligand., PMID:26894505
[Value of serum osteoprotegerin in noninvasive diagnosis of nonalcoholic steatohepatitis]., PMID:26983475
Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer., PMID:27145458
[Effect of tumour necrosis factor α blockade on bone metabolism in chronic inflammatory joint diseases]., PMID:27209224
Interleukin-4 released from human gingival fibroblasts reduces osteoclastogenesis., PMID:27608363
β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis., PMID:27621061
Denosumab for the treatment of adult multisystem Langerhans cell histiocytosis., PMID:28285639
Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study., PMID:28534161
Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts., PMID:28543818
Low-level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical-size defects and increases TGF-β, FGF-2, OPG/RANK and osteocalcin expression., PMID:28556971
Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy., PMID:28580511
Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function., PMID:28854965
The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats., PMID:29649498
Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy., PMID:29699580
Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer., PMID:30425091
Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies., PMID:30460589
Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke., PMID:30496210
Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden., PMID:30496606
Regulation of osteoblast differentiation by osteocytes cultured on sclerostin antibody conjugated TiO2 nanotube array., PMID:30590327
The induction of RANKL molecule clustering could stimulate early osteoblast differentiation., PMID:30594398
Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration., PMID:31101043
RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass., PMID:31120440
Combination of G-CSF and AMD3100 Improves the Anti-inflammatory Effect of Mesenchymal Stem Cells on Inducing M2 Polarization of Macrophages Through NF-κB-IL1RA Signaling Pathway., PMID:31191315
Correlation between Osteoprotegerin Levels and Antiphospholipid Syndrome Parameters., PMID:31414130
Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration., PMID:31425530
Increased frequency of regulatory T cells in pediatric inflammatory bowel disease at diagnosis: a compensative role?, PMID:31715619
Beneficial effects of anti-RANKL antibody in depression-like phenotype, inflammatory bone markers, and bone mineral density in male susceptible mice after chronic social defeat stress., PMID:31790783
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity., PMID:31932605
TNF Receptor: Fc Fusion Protein Downregulates RANKL/OPG Ratio by Inhibiting CXCL16/CXCR6 in Active Ankylosing Spondylitis., PMID:32116188
Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice., PMID:32854340
Iron Overload-Induced Osteocyte Apoptosis Stimulates Osteoclast Differentiation Through Increasing Osteocytic RANKL Production In Vitro., PMID:32995951
Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174
RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp., PMID:33633362
Rhizomelia and Impaired Linear Growth in a Girl with Juvenile Paget Disease: The Natural History of the Condition., PMID:34261073
The Effect of Flowable Composite Resins on Periodontal Health, Cytokine Levels, and Immunoglobulins., PMID:35502340
Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis., PMID:35680906
Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment., PMID:36189226
Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage., PMID:38097649
Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease., PMID:38443806
Genetic Variants in RANK and OPG Could Influence Disease Severity and Bone Remodeling in Patients with Early Arthritis., PMID:39337893
Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?, PMID:39684440
Long-Term Denosumab Treatment in Adults with Juvenile Paget Disease., PMID:40223037
For research use only. Not for human or drug use.
