Anti-Human PAC-1 Antibody (PAC-1)

Catalog No.

FHC33340

Description

The PAC-1 antibody is derived from the fusion of SP-2 mouse myeloma cells with splenic lymphocytes from BALB/c mice that were immunized with human platelets. The PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, αIIbβ3) complex of activated platelets at or near the platelet fibrinogen receptor.

Species reactivity

Human

Host species

Mouse

Isotype

IgM, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

FCM

Target

CD41, ITGAB, GPIIb, ITGA2B, Platelet membrane glycoprotein IIb, GP2B, Integrin alpha-IIb, GPalpha IIb, GPIIIa, Integrin beta-3, CD61, ITGB3, Platelet membrane glycoprotein IIIa, GP3A, PAC-1

Concentration

1.13 mg/ml

Endotoxin level

Please contact with the lab for this information.

Accession

P08514 & P05106

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

PAC-1

Note

For research use only.

Acute Impact of Different Exercise Modalities on Arterial and Platelet Function., PMID:29240651

Increased platelet activation occurs in cystic fibrosis patients and correlates to clinical status., PMID:29274562

Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets., PMID:29306729

PACAP38 in human models of primary headaches., PMID:29453754

PACAP38 and PAC1 receptor blockade: a new target for headache?, PMID:30088106

A preliminary study of platelet hyperactivity in the chronic indeterminate phase of Chagas' disease., PMID:33601755

A Proposed Role of Surfactant in Platelet Function and Treatment of Pulmonary Hemorrhage in Preterm and Term Infants., PMID:30343298

Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins., PMID:30385858

A unique phenotype of acquired Glanzmann thrombasthenia due to non-function-blocking anti-αIIbβ3 autoantibodies., PMID:30388316

Platelet activity and hypercoagulation in type 2 diabetes., PMID:30388964

Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study., PMID:30571484

Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa., PMID:30692520

First description of an IgM monoclonal antibody causing αIIb β3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia., PMID:30868743

Reduced β2-GPI is associated with increased platelet aggregation and activation in patients with prolonged isolated thrombocytopenia after allo-HSCT., PMID:30929196

Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes., PMID:30978226

Altered activation of integrin ɑIIbβ3 on platelets irradiated with ultraviolet C from pathogen-reducing xenon flash., PMID:31105058

Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma., PMID:31326577

Acquired Glanzmann thrombasthenia associated with platelet desialylation., PMID:31869497

Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae-The role of FcγRIIa and platelet factor 4/heparinantibodies., PMID:32237268

Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia., PMID:32272276

Platelet hyperactivation in multiple myeloma is also evident in patients with premalignant monoclonal gammopathy of undetermined significance., PMID:32478420

Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)., PMID:32508559

Small procoagulant platelets in diabetes type 2., PMID:32629151

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19., PMID:32887634

Difference in inflammation, atherosclerosis, and platelet activation between coronary artery aneurysm and coronary artery ectasia., PMID:33209413

Emerging Targets for Migraine Treatment., PMID:34003154

Platelet reticulated forms, size indexes and functional activity. Interactions in healthy volunteers., PMID:34029503

Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination., PMID:34388849

Evaluation of Platelet Activation by HIV Protease Inhibitors - The HIV-PLA II Study., PMID:34393518

Levels of procoagulant microparticles expressing phosphatidylserine contribute to bleeding phenotype in patients with inherited thrombocytopenia., PMID:34475331

Platelet Phenotype and Function Changes With Increasing Duration of Extracorporeal Membrane Oxygenation., PMID:35020670

Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel., PMID:35037555

Clot-targeted magnetic hyperthermia permeabilizes blood clots to make them more susceptible to thrombolysis., PMID:35950914

PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies., PMID:36430275

Platelet Activation and Cytokine Release of Interleukin-8 and Interferon-Gamma-Induced Protein 10 after ChAdOx1 nCoV-19 Coronavirus Vaccine Injection., PMID:36851332

A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia., PMID:36884296

Future targets for migraine treatment beyond CGRP., PMID:37370051

The effects of glucocorticoid plus intravenous immunoglobulin (IVIG) vs IVIG alone on platelet activation in children with Kawasaki disease., PMID:37661679

Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress., PMID:38112069

Targeting the PACAP-38 pathway is an emerging therapeutic strategy for migraine prevention., PMID:38337150

Feasibility and comparability of different platelet function tests in acute stroke with or without prior antiplatelet therapy., PMID:38410198

Optimization of Platelet-Rich Plasma Preparation for Regenerative Medicine: Comparison of Different Anticoagulants and Resuspension Media., PMID:38534483

Off-target effect of high-dose sildenafil on adenosine 5'- diphosphate and collagen-induced platelet activation through mitogen-activated protein kinase pathway in treated BALB/C mice and in vitro experiments: A preliminary study., PMID:38808925

Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology., PMID:38940930

An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding., PMID:38968144

Platelet transfusion enhances pro-aggregatory status shortly after coronary artery bypass grafting (CABG while modulating platelet pro-inflammatory state 1-week post-surgery., PMID:39121235

Association between O-GlcNAc levels and platelet function in obese insulin-resistant subjects., PMID:39300054

Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2., PMID:39640769

Influence of sodium ferulate on neutrophil extracellular traps-platelet activation-mediated endothelial dysfunction in immune small vasculitis., PMID:39917008

An αIIbβ3 Ligand-Mimetic Murine Monoclonal Antibody That Produces Platelet Activation by Engaging the FcγIIa Receptor., PMID:40101235

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