Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease., PMID:39672391
The novel HSP90 monoclonal antibody 9B8 ameliorates articular cartilage degeneration by inhibiting glycolysis via the HIF-1 signaling pathway., PMID:39229534
Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains., PMID:38867123
Angiopoietin-2 Promotes Mechanical Stress-induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF-1α/NF-κB Signaling Pathway., PMID:37475697
Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells., PMID:36980228
Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats., PMID:34049577
The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study., PMID:32559242
Inflammatory Response of Articular Cartilage to Femoroacetabular Impingement in the Hip., PMID:32383968
The protective effects of dulaglutide against advanced glycation end products (AGEs)-induced degradation of type Ⅱ collagen and aggrecan in human SW1353 chondrocytes., PMID:32004530
The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic., PMID:31621572
Analysis of Aggrecanase Activity Using Neoepitope Antibodies., PMID:31463908
Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages., PMID:30989556
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs., PMID:30700002
Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes., PMID:29803826
Depletion of aquaporin 1 decreased ADAMTS‑4 expression in human chondrocytes., PMID:29393494
Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms., PMID:28464560
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis., PMID:27789465
Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model., PMID:27615609
Glucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants., PMID:26958319
[Preparation of rabbit polyclonal antibody against mouse ADAMTS2]., PMID:26927563
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)., PMID:26612259
Carnosol Inhibits Pro-Inflammatory and Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes., PMID:26292290
Characterization of neopeptides in equine articular cartilage degradation., PMID:26124002
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants., PMID:25909781
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification., PMID:25800415
Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications., PMID:25707877
ADAMTS-4 and ADAMTS-5 expression in human temporomandibular joint discs with internal derangement, correlates with degeneration., PMID:25477257
Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity., PMID:25225099
ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain., PMID:23897278
Chondroadherin fragmentation mediated by the protease HTRA1 distinguishes human intervertebral disc degeneration from normal aging., PMID:23673665
Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid., PMID:23438438
The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model., PMID:23295731
MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover., PMID:22670872
Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism., PMID:22432033
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis., PMID:22324945
Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina., PMID:22205175
Zonal differences in meniscus matrix turnover and cytokine response., PMID:22062355
Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina., PMID:21345877
The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration., PMID:21276216
Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice., PMID:20662062
Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine., PMID:20633682
Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan., PMID:20135291
Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4., PMID:20018883
Stigmasterol: a phytosterol with potential anti-osteoarthritic properties., PMID:19786147
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis., PMID:19684582
Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork., PMID:19553617
Proteolytic processing causes extensive heterogeneity of tissue matrilin forms., PMID:19531486
Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373-Ala374., PMID:19071032
Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis., PMID:19035520
Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage., PMID:18975307
For research use only. Not for human or drug use.
