Catalog No.
FHJ44210
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
FCM
Target
Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3
Concentration
3.55 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99523
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0179
Note
For research use only.
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)., PMID:27998951
Binding of thyroglobulin (Tg) to the low-density lipoprotein receptor-associated protein (RAP) during the biosynthetic pathway prevents premature Tg interactions with sortilin., PMID:28382504
ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells., PMID:28528122
Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum., PMID:28638323
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations., PMID:28828399
Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes., PMID:28844948
Detection of retromer assembly in Plasmodium falciparum by immunosensing coupled to Surface Plasmon Resonance., PMID:29654975
Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques., PMID:29690919
Pro-BDNF Contributes to Hypoxia/Reoxygenation Injury in Myocardial Microvascular Endothelial Cells: Roles of Receptors p75NTR and Sortilin and Activation of JNK and Caspase 3., PMID:30046375
proBDNF inhibits the proliferation and migration of OLN‑93 oligodendrocytes., PMID:30132570
Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death., PMID:30800056
SORLA regulates endosomal trafficking and oncogenic fitness of HER2., PMID:31138794
Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain., PMID:31223654
Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress., PMID:31493120
Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis., PMID:31622668
Neurotoxicity of antibodies in cancer therapy: A review., PMID:31731087
Sortilin as a Novel Diagnostic and Therapeutic Biomarker in Chronic Lymphocytic Leukemia., PMID:31908734
The Association Between Sortilin and Inflammation in Patients with Coronary Heart Disease., PMID:32104044
Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer's Disease Human Brains., PMID:32477092
Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall., PMID:32875580
Prosaposin in the rat oviductal epithelial cells., PMID:33242172
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation., PMID:33384578
The multifaceted role of sortilin/neurotensin receptor 3 in human cancer development., PMID:33634506
Oxidized low-density lipoprotein activates extracellular signal-regulated kinase signaling to downregulate sortilin expression in liver sinusoidal endothelial cells., PMID:33694195
Neurotensin: A novel mediator of ovulation?, PMID:33710668
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities., PMID:34366786
The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion., PMID:34379697
Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy., PMID:34380469
Sortilin-related receptor is a druggable therapeutic target in breast cancer., PMID:34564954
New Peptide-Drug Conjugates for Precise Targeting of SORT1-Mediated Vasculogenic Mimicry in the Tumor Microenvironment of TNBC-Derived MDA-MB-231 Breast and Ovarian ES-2 Clear Cell Carcinoma Cells., PMID:34751242
Diagnostic and Therapeutic Implications of Sortilin Expressed on the Surface of Bladder Carcinoma Cells., PMID:35463727
Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells., PMID:35509360
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation., PMID:35978952
Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer., PMID:36089417
A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)2 and taxotere in ovarian cancer cells., PMID:36130999
Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina., PMID:37272764
Sortilin acts as an endocytic receptor for α-synuclein fibril., PMID:37272890
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia., PMID:37322482
Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA., PMID:37634829
Tracking of Prosaposin, a Saposin Precursor, in Rat Testis., PMID:37728096
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier., PMID:37932749
Generation of a Novel SORT1×HER2 Bispecific Antibody-Drug Conjugate Targeting HER2-Low-Expression Tumor., PMID:38003245
Generation and Characterization of SORT1-Targeted Antibody-Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor., PMID:38139459
A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking., PMID:38260508
Phase 1 study of latozinemab in progranulin-associated frontotemporal dementia., PMID:38356474
Propolis Reduces Inflammation and Dyslipidemia Caused by High-Cholesterol Diet in Mice by Lowering ADAM10/17 Activities., PMID:38931216
Designed endocytosis-inducing proteins degrade targets and amplify signals., PMID:39322662
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries., PMID:39402596
SORL1-Mediated EGFR and FGFR4 Regulation Enhances Chemoresistance in Ovarian Cancer., PMID:39858026
Function and application of brain‑derived neurotrophic factor precursors (Review)., PMID:40341415
For research use only. Not for human or drug use.
