Catalog No.
EHC27201
Description
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.
Expression system
Mammalian
Species
Homo sapiens (Human)
Protein length
Beta-Hexosaminidase B (HEXB) is expressed in Mammalian.
Predicted molecular weight
62 kDa
Nature
Recombinant
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Applications
Beta-Hexosaminidase B can release all types of GlcNAc(β1-x) units, including the bisecting GlcNAc structure in N-linked glycans.
Form
Liquid
Storage buffer
PBS pH 7.4,50% glycerin
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 °C for one week .Store at -20 to -80 °C for twelve months from the date of receipt.
Alternative Names
Beta-hexosaminidase subunit beta, N-Acetyl-β-glucosaminidase (NAG),chitobiase,NAG,Beta-N-acetylhexosaminidase subunit beta, N-acetyl-beta-glucosaminidase subunit beta, Cervical cancer proto-oncogene 7 protein, Hexosaminidase subunit B, HCC-7, HEXB, β-Hexosaminidase, β-Hex B, Hex B
Subacute Juvenile Sandhoff Disease: A Progressive Neurodegenerative Disorder., PMID:40415753
Isolation, Characterization, and Anti-Allergic Evaluation of Phytochemicals from Wikstroemia trichotoma., PMID:40362859
Urinary bioorthogonal reporters for the monitoring of the efficacy of chemotherapy for lung cancer and of associated kidney injury., PMID:39880894
Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease., PMID:39791736
Suppression of Pathological Allergen-Specific B Cells by Protein-Engineered Molecules in a Mouse Model of Chronic House Dust Mite Allergy., PMID:39769423
AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity., PMID:39675352
4-Phenylbutyric acid mitigates ER stress-induced neurodegeneration in the spinal cords of a GM2 gangliosidosis mouse model., PMID:39530163
Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase., PMID:39481848
Isolation of holostane-type saponins from the black sea cucumber Holothuria atra and evaluating their anti-allergic activity: in vitro and in silico study., PMID:39435416
Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma., PMID:39353936
Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways., PMID:39221239
Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein., PMID:39211733
A multiplexed targeted method for profiling of serum gangliosides and glycosphingolipids: application to GM2-gangliosidosis., PMID:39190143
L-proline H2SO4 catalyzed synthesis of novel coumarin-based spiroindolino-3,4-dihydropyrimidin-2(1H)-ones: in vitro cytotoxic assay and molecular docking study., PMID:39030285
Nematode Galectin Inhibits Basophilic Leukaemia RBL-2H3 Cells Apoptosis in IgE-Mediated Activation., PMID:39000527
Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma., PMID:38944674
Tandem mass spectrometric enzyme assay for simultaneous detection of Tay-Sachs and Sandhoff diseases in dried blood spots for newborn screening., PMID:38908075
Tachycardia and Acute Kidney Injury among Critically Ill Patients with Sepsis: A Prospective Observational Study., PMID:38870917
Ameliorative effects of Wikstroemia trichotoma 95% EtOH extract on a mouse model of DNCB-induced atopic dermatitis., PMID:38823660
Short-time ozone treatment promotes protease-mediated destruction of B cell allergen epitopes by altering the structural characteristics of whey protein., PMID:38712538
Ameliorative potential of galangin in murine model of ovalbumin-induced allergic rhinitis: a role of PI3K-PKB pathway., PMID:38697189
Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384., PMID:38664572
The effect of Bruton's tyrosine kinase (BTK) inhibitor in the eosinophilic asthma model of mouse., PMID:38579561
Ursodeoxycholic acid alleviates atopic dermatitis-associated inflammatory responses in HaCaT and RBL-2H3 cells and DNCB/DFE-treated mice., PMID:38490296
Marine-Derived Alternariol Monomethyl Ether Alleviates Ovalbumin-Induced Food Allergy by Suppressing MAPK and NF-κB Signaling Pathways of Mast Cells., PMID:38414429
N-acetyl-β-hexosaminidase activity is important for chitooligosaccharide metabolism and biofilm formation in Burkholderia pseudomallei., PMID:38178319
Clinical, Imaging, Genetic, and Disease Course Characteristics in Patients With GM2 Gangliosidosis: Beyond Age of Onset., PMID:38165373
Characterization of novel endo-β-N-acetylglucosaminidases from intestinal Barnesiella intestinihominis that hydrolyze multi-branched complex-type N-glycans., PMID:38142217
Leaves and pseudostems extract of Curcuma longa attenuates immunoglobulin E/bovine serum albumin-stimulated bone marrow-derived cultured mast cell activation and passive cutaneous anaphylaxis in BALB/c mice., PMID:38042384
Dehydroleucodine and xanthatin, two natural anti-inflammatory lactones, inhibit mast cell degranulation by affecting the actin cytoskeleton., PMID:37929805
Differential patterns of lysosomal dysfunction are seen in the clinicopathological forms of primary progressive aphasia., PMID:37917233
Hexa-Histidine, a Peptide with Versatile Applications in the Study of Amyloid-β(1-42) Molecular Mechanisms of Action., PMID:37894616
Morel (Morchella spp.) intake alters gut microbial community and short-chain fatty acid profiles in mice., PMID:37810928
Femoral Structure and Biomechanical Characteristics in Sanfilippo Syndrome Type-B Mice., PMID:37762291
Functional analysis of two SLC9A6 frameshift variants in lymphoblastoid cells from patients with Christianson syndrome., PMID:37381736
A case of Sandhoff disease caused by a novel β-hexosaminidase B (HEXB) mutation c.118delG (p.A40fs*24): A case report from China., PMID:37327298
Biological activity of human IgE monoclonal antibodies targeting Der p 2, Fel d 1, Ara h 2 in basophil mediator release assays., PMID:37228609
Mechanistic Insights into How the Protonation State of D234 Dictates the Reactivity in Streptomyces coelicolor β-N-Acetylhexosaminidase., PMID:37198733
GH20 and GH84 β-N-acetylglucosaminidases with different linkage specificities underpin mucin O-glycan breakdown capability of Bifidobacterium bifidum., PMID:37146969
Isolation of Momordica charantia seed lectin and glycosidases from the protein bodies: Lectin-glycosidase (β-hexosaminidase) protein body membrane interaction reveals possible physiological function of the lectin., PMID:36989986
Plasma GM2 ganglioside potential biomarker for diagnosis, prognosis and disease monitoring of GM2-Gangliosidosis., PMID:36709536
Esomeprazole induces structural changes and apoptosis and alters function of in vitro canine neoplastic mast cells., PMID:36592548
Apigenin attenuates inflammatory response in allergic rhinitis mice by inhibiting the TLR4/MyD88/NF-κB signaling pathway., PMID:36350155
Release of bifidogenic N-glycans from native bovine colostrum proteins by an endo-β-N-acetylglucosaminidase., PMID:36252443
Oxymatrine Alleviates Gentamicin-Induced Renal Injury in Rats., PMID:36234739
Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome., PMID:36233303
[Clinical characteristics and genetic analysis of a child with infantile Sandhoff disease and eosinophilia]., PMID:36184097
CRISPR/nCas9-Based Genome Editing on GM2 Gangliosidoses Fibroblasts via Non-Viral Vectors., PMID:36142595
Antiallergic Effects of N,N-dicoumaroylspermidine Isolated from Lithospermum erythrorhizon on Mast Cells and Ovalbumin-Induced Allergic Rhinitis., PMID:36142314
The endoglycosidase activity of Dispersin B is mediated through electrostatic interactions with cationic poly-β-(1→6)-N-acetylglucosamine., PMID:36083143
For research use only. Not for human or drug use.
