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Research Grade Anti-Human CCL24/Eotaxin-2/MPIF-2 Antibody (CM101)

Catalog #:   DHA04001 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-nd
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHA04001

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-nd

Clonality

Monoclonal

Target

MPIF2, Eosinophil chemotactic protein 2, Small-inducible cytokine A24, CCL24, Eotaxin-2, SCYA24, MPIF-2, Myeloid progenitor inhibitory factor 2, CK-beta-6, C-C motif chemokine 24

Concentration

1.77 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O00175

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

NaAc, 0.2M Arg, pH5.5

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CM-101, CM101

Clone ID

CM101

Data Image
  • SDS-PAGE
    SDS PAGE for CM101
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Molecular imaging of fibrosis: recent advances and future directions, PMID: 30601139

CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism, PMID: 11824380

CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury, PMID: 9789063

Phase I study of the antineovascularization drug CM101, PMID: 9815693

Macrophage stimulation using a group B-streptococcus exotoxin (CM101) leads to axonal regrowth in the injured optic nerve, PMID: 15096692

Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines, PMID: 25915462

Isolation and identification of the group B streptococcal toxin CM101 from infants with sepsis, PMID: 10969257

Soluble E-selectin in cancer patients as a marker of the therapeutic efficacy of CM101, a tumor-inhibiting anti-neovascularization agent, evaluated in phase I clinical trail, PMID: 9119883

Collagen-targeted molecular imaging in diffuse liver diseases, PMID: 32737546

Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis, PMID: 11751519

CM101 treatment overrides tumor-induced immunoprivilege leading to apoptosis, PMID: 11059768

Islet Culture/Preservation Before Islet Transplantation, PMID: 26858905

Group B streptococcus, PMID: 10023965

Advances in functional and molecular MRI technologies in chronic liver diseases, PMID: 32585160

Extracellular virulence factors of group B Streptococci, PMID: 14977587

Acute inflammatory changes in subcutaneous microtumors in the ears of mice induced by intravenous CM101 (GBS toxin), PMID: 8781569

Functional studies on the anti-pathoangiogenic properties of CM101, PMID: 14517462

CM101, a polysaccharide antitumor agent, does not inhibit wound healing in murine models, PMID: 7538506

Metabolic engineering of the morphology of Aspergillus oryzae by altering chitin synthesis, PMID: 11916702

PSK as a chemopreventive agent, PMID: 8318880

Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI, PMID: 32611647

A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage, PMID: 32039405

Protein-bound polysaccharide-K (PSK) induces apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells, PMID: 22753720

Dye-sensitized solar cells based on a donor-acceptor system with a pyridine cation as an electron-withdrawing anchoring group, PMID: 23081757

Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound, PMID: 21249323

Protein-bound polysaccharide-K (PSK) induces apoptosis and inhibits proliferation of promyelomonocytic leukemia HL-60 cells, PMID: 21868514

Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis, PMID: 31129606

Protein-bound polysaccharide-K induces apoptosis via mitochondria and p38 mitogen-activated protein kinase-dependent pathways in HL-60 promyelomonocytic leukemia cells, PMID: 23604455

A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae), PMID: 9457474

Viscoelastic properties of waxy and nonwaxy rice flours, their fat and protein-free starch, and the microstructure of their cooked kernels, PMID: 17636935

Modulation of interleukin-12 mRNA expression in leukocytes of cancer patients treated with CM101, PMID: 8958950

Clinical trials of anti-vascular agent group B Streptococcus toxin (CM101), PMID: 14517391

CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis, PMID: 29156148

A new selective medium for the culture of clostridia from human faeces, PMID: 7184767

[Development of anti tumor agents targeting angiogenesis], PMID: 9030228

Improved recovery of myelosuppression following chemotherapy in mice by combined administration of PSK and various cytokines, PMID: 7532894

Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy, PMID: 12168863

Protective effect of Group B Streptococcus type-III polysaccharide conjugates against maternal colonization, ascending infection and neonatal transmission in rodent models, PMID: 29416049

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design, PMID: 22101769

Antibodies to type III group B streptococcal polysaccharide in breast milk, PMID: 15602200

[Effect of PSK on recurrence of stage II/III gastric cancer], PMID: 21224540

Characterization of polysaccharide conformational epitopes by surface plasmon resonance, PMID: 14579587

Isolation of carbohydrate-specific CD4(+) T cell clones from mice after stimulation by two model glycoconjugate vaccines, PMID: 23196974

Angiogenesis research enjoys growth spurt in the 1990s, PMID: 8637041

Construction of designer glycoconjugate vaccines with size-specific oligosaccharide antigens and site-controlled coupling, PMID: 12559788

Potentiation of virulence by group B streptococcal polysaccharides, PMID: 6376652

Group B streptococcal type II and III conjugate vaccines: physicochemical properties that influence immunogenicity, PMID: 16893995

Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice, PMID: 12496386

Definition of a bacterial virulence factor: sialylation of the group B streptococcal capsule, PMID: 2554337

Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14, PMID: 11895934

Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life., PMID:40073088

Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation., PMID:39566608

Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma., PMID:39097197

Macrophage activation and inflammatory priming by anti-MAA antibodies in rheumatoid arthritis., PMID:38969267

Targeting CCL24 in Inflammatory and Fibrotic Diseases: Rationale and Results from Three CM-101 Phase 1 Studies., PMID:38822943

Expression of inducible nitric oxide synthase, nitrotyrosine, eosinophilic peroxidase, eotaxin-3, and galectin-3 in patients with gastroesophageal reflux disease, eosinophilic esophagitis, and in healthy controls: a semiquantitative image analysis of 3,3'-diaminobenzidine-stained esophageal biopsies., PMID:38679488

Characterization of the Pro-Inflammatory and Pruritogenic Transcriptome in Skin Lesions of the Experimental Canine Atopic Acute IgE-Mediated Late Phase Reactions Model and Correlation to Acute Skin Lesions of Human Atopic Dermatitis., PMID:38535843

Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia., PMID:38360867

The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging Patient Serum Proteomics to Preclinical Data., PMID:38334601

The Eotaxin-1/CCR3 Axis and Matrix Metalloproteinase-9 Are Critical in Anti-NC16A IgE-Induced Bullous Pemphigoid., PMID:37672029

The Role of CCL24 in Systemic Sclerosis., PMID:37555717

CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis., PMID:37345655

CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor-associated myeloid cells., PMID:37275530

Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts., PMID:37129566

Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy., PMID:36380370

CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment., PMID:36342195

Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer., PMID:36324077

Cytokines/chemokines and soluble immune checkpoint molecules in anti-GABAB receptor encephalitis., PMID:36270252

CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation., PMID:36131165

Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis., PMID:35624133

Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway., PMID:35296330

Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves' Disease., PMID:33912135

IL-1α antibody inhibits dose-dependent exacerbation of eosinophilic inflammation by crude house-dust-mite antigen in the conjunctiva of an atopic keratoconjunctivitis mouse model., PMID:33428487

Non-invasive Embryo Assessment: Altered Individual Protein Profile in Spent Culture Media from Embryos Transferred at Day 5., PMID:33151525

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps., PMID:32935490

Increased serum CCL26 level is a potential biomarker for the effectiveness of anti-PD1 antibodies in patients with advanced melanoma., PMID:32658051

Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis., PMID:32419252

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae., PMID:32394439

Possible Mechanisms of Eosinophil Accumulation in Eosinophilic Pneumonia., PMID:32326200

Biologics or immunotherapeutics for asthma?, PMID:32275962

Differential Gene Expression of Lymphocytes Stimulated with Rhinovirus A and C in Children with Asthma., PMID:32142615

Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma., PMID:32051393

A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage., PMID:32039405

IgG4 Related Autoimmune Pancreatitis: An Overview and the Emerging Role of Serum Eotaxin as a Potential Treatment Target., PMID:31542909

Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma., PMID:31330043

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner., PMID:31285764

Allergic rhinitis is associated with complex alterations in high-density lipoprotein composition and function., PMID:31185305

Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis., PMID:31129606

The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation., PMID:30943376

Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice., PMID:30910757

A synthetic glycosaminoglycan reduces sinonasal inflammation in a murine model of chronic rhinosinusitis., PMID:30252910

Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody-Negative Eosinophilic Granulomatosis with Polyangiitis., PMID:30179583

Aggregates of IVIG or Avastin, but not HSA, modify the response to model innate immune response modulating impurities., PMID:30065306

Mesenchymal Stromal Cell (MSC)-Derived Combination of CXCL5 and Anti-CCL24 Is Synergistic and Superior to MSC and Cyclosporine for the Treatment of Graft-versus-Host Disease., PMID:29883796

Extensive serum biomarker analysis in patients with nasopharyngeal carcinoma., PMID:29759660

Novel mediators of statin effects on plaque in HIV: a proteomics approach., PMID:29369166

Interleukin-33 promotes the inflammatory reaction in chronic rhinosinusitis with nasal polyps by NF-κB signaling pathway., PMID:29131267

Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity., PMID:28785009

Human lactoferrin induces asthmatic symptoms in NC/Nga mice., PMID:28774951

Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor., PMID:28623741

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1314

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For research use only. Not for human or drug use.

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Research Grade Anti-Human CCL24/Eotaxin-2/MPIF-2 Antibody (CM101) [DHA04001]
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