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Research Grade Etanercept

Catalog #:   DHB94429 Specific References (99) DATASHEET
Host species: Human
Isotype: IgG1-Fc
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHB94429

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-Fc

Clonality

Monoclonal

Target

TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01375

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAS: 185243-69-0

Clone ID

Etanercept

Data Image
  • SDS-PAGE
    SDS PAGE for Etanercept
  • Bioactivity
    Detects TNFa/TNF-alpha in indirect ELISAs.
References

Etanercept for the treatment of rheumatoid arthritis, PMID: 29482402

Review of Biosimilar Trials and Data on Etanercept in Rheumatoid Arthritis, PMID: 30411183

Etanercept biosimilar SB-4, PMID: 30616405

Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial, PMID: 30747501

[Etanercept], PMID: 31204122

Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients in Sustained Remission, PMID: 33205906

GP2015: An Etanercept Biosimilar, PMID: 28940172

Etanercept-induced palisaded neutrophilic granulomatous dermatitis, PMID: 33279312

Etanercept for treating axial spondyloarthritis, PMID: 28682112

Etanercept (SB4): A Review in Autoimmune Inflammatory Diseases, PMID: 27455991

Safety update of etanercept treatment for moderate to severe plaque psoriasis, PMID: 32178543

Etanercept as a TNF-alpha inhibitor depresses experimental retinal neovascularization, PMID: 33043386

Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial, PMID: 31122296

Etanercept for pediatric acrodermatitis continua of Hallopeau: A case report and literature review, PMID: 32700773

Etanercept in the treatment of psoriatic arthritis, PMID: 25455504

The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study, PMID: 28448562

Etanercept for the treatment of non-radiographic axial spondyloarthritis, PMID: 26788837

Etanercept for Treatment of Taxane-Induced Pneumonitis, PMID: 31219735

Erythromycin-induced pemphigus foliaceus successfully treated with etanercept, PMID: 32808715

The EGALITY study: a confirmatory, randomized, double-blind study comparing the efficacy, safety and immunogenicity of GP2015, a proposed etanercept biosimilar, vs. the originator product in patients with moderate-to-severe chronic plaque-type psoriasis, PMID: 27787890

Intra-articular injection of etanercept versus glucocorticoids in rheumatoid arthritis patients, PMID: 32623650

[Etanercept-induced subacute thyroiditis. Case report and literature review], PMID: 28942661

Treatment of psoriasis with etanercept: the typical patient profile, PMID: 27073046

Lymphatic Distribution of Etanercept Following Intravenous and Subcutaneous Delivery to Rats, PMID: 32720159

Etanercept as Adjunctive Primary Therapy in Kawasaki Disease, PMID: 31048416

Efficacy and safety of etanercept in the treatment of sciatica: A systematic review and meta-analysis, PMID: 28779960

Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats, PMID: 32569601

Etanercept combined with systemic drugs or phototherapy for treatment of psoriasis, PMID: 25529463

Long-term safety and effectiveness of etanercept in JIA: an 18-year experience from the BiKeR registry, PMID: 33121528

Functional analysis of glycosylation in Etanercept: Effects over potency and stability, PMID: 32682933

Update upon efficacy and safety of etanercept for the treatment of spondyloarthritis and juvenile idiopathic arthritis, PMID: 28837372

TNF-α modulation via Etanercept restores bone regeneration of atrophic non-unions, PMID: 32745691

Targeted cutaneous delivery of etanercept using Er:YAG fractional laser ablation, PMID: 32194205

Etanercept for Ankylosing Spondylitis With Coexisting Demyelinating Myelitis, PMID: 30199382

Cardiovascular effects of Etanercept in patients with psoriatic arthritis: evidence from the cardiovascular risk in rheumatic diseases database, PMID: 26618553

Clinical experience with the etanercept biosimilar SB4 in psoriatic patients, PMID: 30610544

A Case Series of Patients With Psoriasis Exposed to Biologic Therapy During Pregnancy: The BIOBADADERM Register and a Review of the Literature, PMID: 27765165

Adherence to etanercept therapy in rheumatoid arthritis patients during 3 years of follow-up, PMID: 30300358

Can etanercept treatment failure in moderate-to-severe psoriasis be overcome by addition of low-dose methotrexate? A single-center experience, PMID: 29466892

Use of Etanercept for Psoriasis in a Renal Transplant Recipient, PMID: 31627849

Efficacy of etanercept for treating the active rheumatoid arthritis: an updated meta-analysis, PMID: 26354025

Impact of pharmacogenomics upon the therapeutic response to etanercept in psoriasis and psoriatic arthritis, PMID: 28750567

Etanercept biosimilar associated with Guillain-Barré syndrome: insights from a case, PMID: 31309782

[Actual treatments of psoriasis : from etanercept to anti-IL17 and anti-IL23 antagonists], PMID: 32496683

Use of Etanercept in a Series of Pediatric Patients With Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis Spectrum Disease, PMID: 32347889

Prophylactic etanercept treatment in cisplatin ototoxicity, PMID: 28730299

Oxaliplatin-Induced Rather Than Taxane-Induced Pneumonitis Was Responsive to Etanercept, PMID: 31682545

Retention and survival rate of etanercept in psoriasis over 15 years and patient outcomes during the COVID-19 pandemic: The real-world experience of a single center, PMID: 33274541

Batch-to-Batch Consistency of SB4 and SB2, Etanercept and Infliximab Biosimilars, PMID: 31925703

A successful case of etanercept used for idiopathic granulomatous mastitis, PMID: 30790374

Two Consecutive Days of Low-Dose Methotrexate Toxicity: A Diagnostic Challenge., PMID:40520835

Tumor necrosis factor-alpha in mediation of acute salt loading induced natriuresis in mice; evidence for its physiological role in regulating kidney function., PMID:40517012

Comparison and analysis of biological drug consumption in two Italian hospital settings: Governance actions and prescribing appropriateness., PMID:40494065

Total Knee Arthroplasty in a Patient With Isolated Rheumatoid Arthritis of the Knee., PMID:40491655

Drug survival, long-term safety and efficacy of anti-TNF-alpha biosimilars: a monocentric retrospective study., PMID:40485573

Pharmacogenomics of TNF inhibitors., PMID:40469293

Evaluation of Factors Associated With Uveitis Onset Timing in Oligoarticular Juvenile Idiopathic Arthritis., PMID:40454975

Etanercept, a peripherally restricted TNF inhibitor, enhances cocaine-induced locomotor behaviors in male, but not female, rats., PMID:40446442

Psoriasis complicated with polymyositis successfully treated with Ixekizumab: A case report., PMID:40441209

Systematic review of comparative studies on emerging psoriasis treatments: comparing biologics with biologics, small molecule inhibitors with small molecule inhibitors, and biologics with small molecule inhibitors., PMID:40439875

Predicting Clinical Response to Monoclonal TNF Inhibitors in Rheumatoid Arthritis: A Transcriptomic Approach Based on Transmembrane TNF Reverse Signaling and Nrf2 Activation., PMID:40428231

Comparative efficacy, safety and immunogenicity of biosimilars and their reference biologic drugs in ankylosing spondylitis: a systematic review and meta-analysis of randomized controlled trials., PMID:40418343

The Relationship Between TNF-α Inhibitor Potency and HBV Reactivation in Patients With Rheumatic Disorders., PMID:40418092

Rapid baseline hump-free analysis of therapeutic proteins in a wide molecular weight range by SDS - capillary agarose gel electrophoresis., PMID:40409905

Coexistent Ankylosing Spondylitis and Ocular Toxocariasis in a Pediatric Patient Manifesting As Bilateral Panuveitis., PMID:40406765

Evaluating changes in baseline characteristics and drug utilisation pattern in patients with moderate-to-severe psoriasis: findings from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) Cohort., PMID:40402160

Dual therapy for amanita phalloides-induced acute liver failure in mice: A combination of etanercept and alpha-1 antitrypsin., PMID:40398510

Systematic review and meta-analysis of the efficacy of biologic and targeted synthetic therapies in sarcoidosis., PMID:40393718

Identification of therapeutic targets for neonatal respiratory distress: A systematic druggable genome-wide Mendelian randomization., PMID:40388790

Risk of adverse events of psoriasis treatment with biologic agents and new small molecules-BIOBADADERM Registry., PMID:40387427

Ethanol-induced dysfunction of the mesenteric perivascular adipose tissue is driven by mineralocorticoid receptors., PMID:40377659

Cardiovascular Outcomes of Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis: A Review of the Current Evidence., PMID:40376321

Efficacy of Tumor Necrosis Factor Inhibitors for Refractory Leg Ulcers in Cutaneous Polyarteritis Nodosa: A Case Series., PMID:40374513

Drug survival and predictor factors for discontinuation of first-line biologic therapy in rheumatoid arthritis: data from a real-world single-centre study., PMID:40371548

Drug-associated infections and infestations in older adults with tumor necrosis factor-alpha inhibitors: a real-world retrospective and pharmacovigilance study., PMID:40371340

Real-World Insights From Türkiye: Biologic DMARDs Usage in Spondyloarthritis Patients With Chronic Kidney Disease., PMID:40358366

Assessing real-world treatment with SDZ ETN (an etanercept biosimilar) in people with rheumatic diseases included in the COMPACT study: a plain language summary., PMID:40353738

Subclinical Enthesitis in Children with Chronic Nonbacterial Osteomyelitis., PMID:40353601

Aggregate Distributional Cost-Effectiveness Analysis of Biologics for the Treatment of Ankylosing Spondylitis in Chile., PMID:40329067

Compatibility between Proteins and Polysaccharide Excipients in Oral Delivery Tablets., PMID:40323221

TNF-α antagonist alleviates muscular layer enlargement but does not prevent myenteric neuronal loss in the colon of streptozotocin-induced diabetic rats., PMID:40288461

Impact of excess weight on clinical features of psoriasis and efficacy of biologic therapies in children with severe psoriasis: Analysis of data from the BiPe cohorts., PMID:40286464

Patient-Reported Outcome Measures in Patients with Rheumatoid Arthritis, Psoriasis, or Psoriatic Arthritis Treated with GP2015, an Etanercept Biosimilar: Results from Two Phase III Studies (EGALITY and EQUIRA)., PMID:40279006

The impact of biosimilar use on healthcare utilization among new users of etanercept for inflammatory arthritis: a population-based regression discontinuity analysis., PMID:40270586

Predicting extra-musculoskeletal and peripheral manifestations and their role on biologic treatment in patients with axial spondyloarthritis: TReasure experience., PMID:40264484

Recommendations for the Use of Disease-Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review., PMID:40256995

Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo., PMID:40251677

Characterising infusion/injection-related reactions in patients with rheumatoid arthritis treated with biologic agents., PMID:40249052

Relapsing-remitting multiple sclerosis as a potential consequence of thalidomide treatment: A case report., PMID:40245782

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Current Management and Innovative Therapies., PMID:40231717

Risk of Serious Infections in Patients Treated With Biologic or Targeted-synthetic Disease Modifying Antirheumatic Drugs in Qatar., PMID:40230031

Drug- and Vaccine-Induced Cutaneous T-Cell Lymphoma: A Systematic Review of the Literature., PMID:40226161

Immunotherapy as a treatment for type 1 diabetes mellitus in children and young adults: A comprehensive systematic review and meta-analysis., PMID:40215252

Effects of biological agents on lipid profile and hemogram parameters in patients with psoriasis., PMID:40208364

Dual biological treatments in immune-mediated disorders: a single center experience., PMID:40200173

From the Cochrane Library: Anti-tumor necrosis factor agents for pediatric psoriasis., PMID:40187532

Optimizing Maternal and Fetal Antibody Exposure and Dosing Regimens During Pregnancy Using a Physiologically Based Pharmacokinetic Model., PMID:40181734

Analysis of the Reduction in the Duration of Sick Leave for 32,512 Psoriasis Patients Following the Integration of Targeted Therapies for Psoriatic Disease into the Brazilian Healthcare System: a Retrospective Cohort Study., PMID:40171531

Anti-TNFα as an Adjunctive Therapy in Pancreas and Kidney Transplantation., PMID:40170787

Datasheet

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Research Grade Etanercept.pdf

 

$ 426
Product specifications
100 μg 426 1 mg 1704

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Research Grade Etanercept [DHB94429]
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