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Research Grade Aflibercept

Catalog #:   DHD12629 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG1-Fc
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD12629

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-Fc

Clonality

Monoclonal

Target

Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A

Concentration

2.37 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15692

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAS: 862111-32-8

Clone ID

Aflibercept

Data Image
  • Bioactivity
    Detects Human VEGFA in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Aflibercept
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration, PMID: 23084240

Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema: Two-Year Results from a Comparative Effectiveness Randomized Clinical Trial, PMID: 26935357

Aflibercept, bevacizumab or ranibizumab for diabetic macular oedema: recent clinically relevant findings from DRCR.net Protocol T, PMID: 28837425

Intravitreal Ziv-Aflibercept: A Comprehensive Review, PMID: 31314638

Aflibercept for neovascular age-related macular degeneration, PMID: 26857947

SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB, PMID: 28106709

Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial, PMID: 28551167

Persistent Macular Thickening Following Intravitreous Aflibercept, Bevacizumab, or Ranibizumab for Central-Involved Diabetic Macular Edema With Vision Impairment: A Secondary Analysis of a Randomized Clinical Trial, PMID: 29392288

Nephrotoxicity Associated with Novel Anticancer Agents (Aflibercept, Dasatinib, Nivolumab): Case Series and Nephrological Considerations, PMID: 32664269

Ranibizumab or Aflibercept for Diabetic Macular Edema: Comparison of 1-Year Outcomes from the Fight Retinal Blindness! Registry, PMID: 31932092

Aflibercept, PMID: 23444216

The cost-effectiveness of bevacizumab, ranibizumab and aflibercept for the treatment of age-related macular degeneration-A cost-effectiveness analysis from a societal perspective, PMID: 29772018

Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen, PMID: 22949147

HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration, PMID: 30986442

Aflibercept, PMID: 22460118

Aflibercept: A review of its effect on the treatment of exudative age-related macular degeneration, PMID: 30813810

Intravitreal aflibercept and ranibizumab for pachychoroid neovasculopathy, PMID: 30765771

Change in Diabetic Retinopathy Through 2 Years: Secondary Analysis of a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab, PMID: 28448655

Aflibercept: A Review in Metastatic Colorectal Cancer, PMID: 26220913

Real-World Effectiveness and Real-World Cost-Effectiveness of Intravitreal Aflibercept and Intravitreal Ranibizumab in Neovascular Age-Related Macular Degeneration: Systematic Review and Meta-Analysis of Real-World Studies, PMID: 31728825

A Randomized, Double-Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab versus Aflibercept in Patients with Visual Impairment due to Diabetic Macular Edema (KITE), PMID: 32131127

Intravitreal Ziv-Aflibercept: Clinical Effects and Economic Impact, PMID: 28971631

Aflibercept: A Review of Its Use in the Management of Diabetic Eye Complications, PMID: 27166390

Potential of subconjunctival aflibercept in treating choroidal neovascularization, PMID: 32795527

Aflibercept (VEGF-TRAP): the next anti-VEGF drug, PMID: 21999177

Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD, PMID: 25001321

Aflibercept: A Review in Macular Oedema Secondary to Branch Retinal Vein Occlusion, PMID: 28365905

Ziv-aflibercept (Zaltrap) for the treatment of metastatic colorectal cancer, PMID: 24259608

Aflibercept: A Review of Its Use in Diabetic Macular Oedema, PMID: 26056030

Intravitreal Aflibercept in Diabetic Macular Edema: Long-Term Outcomes, PMID: 28427067

Aflibercept in the Treatment of Diabetic Macular Edema: A Review and Consensus Paper, PMID: 29077188

Transport and fate of aflibercept in VEGF-A 165-challenged retinal endothelial cells, PMID: 32712182

Aflibercept in age-related macular degeneration: evaluating its role as a primary therapeutic option, PMID: 28548650

Aflibercept for the treatment of diabetic macular edema, PMID: 26907516

Influence of aflibercept on platelet activation profile, PMID: 29908884

A preclinical and clinical review of aflibercept for the management of cancer, PMID: 22264850

Aflibercept for age-related macular degeneration: a game-changer or quiet addition?, PMID: 22813448

Switching between ranibizumab and aflibercept for the treatment of neovascular age-related macular degeneration, PMID: 29476754

Intravitreal aflibercept injection in Indian eyes with retinopathy of prematurity, PMID: 31124509

Aflibercept for intravitreal injection: in neovascular age-related macular degeneration, PMID: 23038609

Ziv-aflibercept: a novel angiogenesis inhibitor for the treatment of metastatic colorectal cancer, PMID: 24128964

Aflibercept a new target therapy in cancer treatment: a review, PMID: 26224565

Evaluation of aflibercept in the treatment of metastatic colorectal cancer, PMID: 25152076

INTRAVITREAL AFLIBERCEPT AND RANIBIZUMAB INJECTIONS FOR TYPE 3 NEOVASCULARIZATION, PMID: 28984737

HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration, PMID: 32574761

Ranibizumab and aflibercept for the treatment of wet age-related macular degeneration, PMID: 26076760

Aflibercept regulates retinal inflammation elicited by high glucose via the PlGF/ERK pathway, PMID: 31351870

PHARMACOKINETIC STUDY OF INTRAVITREAL AFLIBERCEPT IN HUMANS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION, PMID: 31145389

Aflibercept (eylea) for age-related macular degeneration, PMID: 22354219

Aflibercept: an update on recent milestones achieved, PMID: 25588083

Faricimab for treatment-resistant choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD): seven-months results using artificial intelligence and OCTA., PMID:40528210

Clinical Trials of Aflibercept Biosimilars: A Review., PMID:40526023

Intraocular inflammation following intravitreal injections of anti-vascular endothelial growth factor drugs., PMID:40522452

Interventions for central serous chorioretinopathy: a network meta-analysis., PMID:40522203

Age-independent anti-angiogenic therapy for choroidal neovascularization by targeting secretogranin III., PMID:40518488

Real-World 5-Year Outcomes of Age-Related Macular Degeneration with Bevacizumab as First-Line Anti-VEGF., PMID:40517351

A randomized, double-masked parallel-group, multicenter clinical study evaluating the efficacy and safety of the biosimilar candidate AVT06 compared to the reference product aflibercept in participants with neovascular age-related macular degeneration., PMID:40512025

Six-year findings of polypoidal choroidal vasculopathy in the EVEREST II study: Japanese subgroup analysis., PMID:40504425

Factors determining timing of first recurrence after three loading aflibercept injections in newly diagnosed neovascular age-related macular degeneration., PMID:40504424

Efficacy of switching from existing anti-vascular endothelial growth factor drugs to ranibizumab biosimilar in neovascular age-related macular degeneration., PMID:40500585

A Prospective Observational Study of Intravitreal Aflibercept in Retinal Vein Occlusion with Initially Good Visual Acuity., PMID:40499162

Effect of Faricimab versus Aflibercept on Hyperreflective Foci in Patients with Diabetic Macular Edema from the YOSEMITE/RHINE Trials., PMID:40496217

Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology., PMID:40493193

Usage of brolucizumab as treatment for wet age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV): A narrative review., PMID:40489855

Anti-VEGFs for Diabetic Macular Oedema: Analysis of Efficacy, Safety, and Cost of More Durable Therapies from a Dutch Societal Perspective., PMID:40481910

Intravitreal anti-vascular endothelial growth factor injections and risks of stroke in patients with neovascular age-related macular degeneration-A registry-based cohort study., PMID:40481786

A swept-source optical coherence tomography study of the spectrum of laser pointer maculopathy., PMID:40474312

TALON Phase IIIb Study: 32 Week Primary Results of Brolucizumab Using Treat and Extend for Neovascular Age Related Macular Degeneration., PMID:40466770

Corrigendum: Efficacy and safety of intravitreal injection of aflibercept biosimilar for treating diabetic macular edema., PMID:40458651

Extended duration of VEGF inhibition with aflibercept 8 mg: the role of reduced ocular clearance., PMID:40456958

Author Correction: Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema., PMID:40456888

Association between intravitreal anti-vascular endothelial growth factor agents and hypertension: a meta-analysis., PMID:40456283

Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model., PMID:40455045

Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration., PMID:40451292

Managing Choroidal Neovascularization in Pseudoxanthoma Elasticum: Outcomes of Vitrectomy and Intravitreal Ranibizumab/Aflibercept Therapy-A Case Report., PMID:40438152

Oral lamivudine in diabetic macular edema: A randomized, double-blind, placebo-controlled clinical trial., PMID:40436012

Real-Life Treatment Intervals and Morphological Outcomes Following the Switch to Faricimab Therapy in Neovascular Age-Related Macular Degeneration., PMID:40423060

Effectiveness and safety of anti-vascular endothelial growth factor therapies for macular edema in retinal vein occlusion: A systematic review and network meta-analysis of randomized controlled trials., PMID:40419166

Successful Response to Intravitreal Faricimab Injections in a Case of Neovascular Age-Related Macular Degeneration in Vitrectomized Eyes., PMID:40400877

Twelve-Month Outcomes of Faricimab for Patients with Sub-Optimally Responsive Diabetic Macular Oedema: A Retrospective Single-Centre Study., PMID:40396158

Response: Aflibercept for the treatment of pigmentary retinopathy in Kearns-Sayre Syndrome?, PMID:40392487

Aflibercept for the treatment of pigmentary retinopathy in Kearns-Sayre syndrome?, PMID:40389721

Socioeconomic Disparities in Intravitreal Injection Use and Anti-VEGF Agent Selection: Aflibercept/Ranibizumab Versus Bevacizumab., PMID:40383690

Prospective evaluation of soluble CD14 as a biomarker following five aflibercept treatments in diabetic macular edema., PMID:40379891

Successful use of aflibercept for high cardiac output in hereditary hemorrhagic telangiectasia after failure of pazopanib and bevacizumab therapy., PMID:40379104

Recurrence of Macular Edema in Branch Retinal Vein Occlusion-A Comparison of Aflibercept and Ranibizumab in a Randomized Trial., PMID:40373873

Sustainable Practices in Anti-VEGF Therapy: A 15-Year Bibliometric Analysis of Ranibizumab for Age-Related Macular Degeneration., PMID:40365539

Faricimab Reverts VEGF-A165-Induced Impairment of the Barrier Formed by Retinal Endothelial Cells., PMID:40362554

Silicone oil microdroplets from syringes with intravitreal anti-vascular endothelial growth factor and complement inhibitor injections., PMID:40359347

Bilateral Idiopathic Multifocal Pigment Epithelial Detachments: A Case Series and Review of Literature., PMID:40359333

Visual outcome following initiation of first injection versus after three monthly doses of aflibercept 2 mg for treatment naïve age-related macular degeneration to inform clinical trial designs: PRECISE Report No. 6., PMID:40355704

Long-term outcomes of the observe-and-plan regimen in treating neovascular age-related macular degeneration: a retrospective real-life analysis., PMID:40348918

Comprehensive multi-omics and pharmacokinetics reveal sclareol's role in inhibiting ocular neovascularization., PMID:40347925

Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis., PMID:40347224

Plain-language commentary: 2-year findings from the FIREFLEYE next study looking at how well aflibercept injected into affected eyes in babies with retinopathy of prematurity works and how safe it is compared with laser treatment., PMID:40342575

Improved functional and morphological outcomes with faricimab in nAMD eyes with poor response to prior intravitreal anti-VEGF therapy., PMID:40338383

Endophthalmitis following intravitreal injections at a tertiary center: real-life data on incidence, risk factors, management strategies, and visual outcomes., PMID:40335933

Uncommon Therapeutic Approaches for Patients with Recurrent Central Serous Chorioretinopathy: case report and literature review., PMID:40330964

Different clinical presentations of persistent placoid maculopathy: a case series., PMID:40329229

Comparison of treatment routine using aflibercept: Strict vs. relaxed retreatment regimen (TOLERANT study)-A non-inferiority, randomized controlled trial., PMID:40326420

Datasheet

Document Download

Research Grade Aflibercept.pdf

 

$ 426
Product specifications
100 μg 426 1 mg 1704

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Research Grade Aflibercept [DHD12629]
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