Catalog No.
EHB96501
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Tyr235
Predicted molecular weight
27.44 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UX15
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LAYN, Layilin
Note
For research use only.
An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence., PMID:21740549
Layilin, a talin-binding hyaluronan receptor, is expressed in human articular chondrocytes and synoviocytes and is down-regulated by interleukin-1β., PMID:22722918
Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin., PMID:23048036
Secretion of inflammatory factors from chondrocytes by layilin signaling., PMID:25150153
Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells., PMID:26410531
Transcriptome profiling of human FoxP3+ regulatory T cells., PMID:26686412
Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity., PMID:28448136
Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review., PMID:29429372
Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice., PMID:30060618
LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers., PMID:30761122
Layilin enhances the invasive ability of malignant glioma cells via SNAI1 signaling., PMID:31145904
Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol-Induced Disruption of Epithelial Tight Junctions Through a layilin-Dependent Mechanism in Caco-2 Cells., PMID:31237689
Understanding tumor-infiltrating lymphocytes by single cell RNA sequencing., PMID:31699218
Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats., PMID:31712153
Layilin augments integrin activation to promote antitumor immunity., PMID:32539073
Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs., PMID:32809975
Increased IGFBP7 Expression Correlates with Poor Prognosis and Immune Infiltration in Gastric Cancer., PMID:33531979
Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells., PMID:33676182
Layilin Anchors Regulatory T Cells in Skin., PMID:34470859
The regulatory effect of hyaluronan on human mesenchymal stem cells' fate modulates their interaction with cancer cells in vitro., PMID:34707175
Assessment of anti-inflammatory and antioxidant activity of quercetin-rutin blend (SophorOx™) - an invitro cell based assay., PMID:35179009
Proteomics-Based Serum Alterations of the Human Protein Expression after Out-of-Hospital Cardiac Arrest: Pilot Study for Prognostication of Survivors vs. Non-Survivors at Day 1 after Return of Spontaneous Circulation (ROSC)., PMID:35207267
Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes., PMID:35618095
Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+T cells., PMID:36260222
ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis., PMID:36398067
Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides., PMID:36805871
The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis., PMID:37102425
Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer., PMID:37335337
Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status., PMID:37642473
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation., PMID:37996402
Assessment of Anti-Inflammatory and Antioxidant Activities of a Proprietary Preparation of Quercetin-Rutin Blend (SophorOx™) in Exercised Rats., PMID:38371227
Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study., PMID:38573314
Integrative single-cell analysis of LUAD: elucidating immune cell dynamics and prognostic modeling based on exhausted CD8+ T cells., PMID:38596689
Associations between multiple neurological biomarkers and distal sensorimotor polyneuropathy: KORA F4/FF4 study., PMID:38872492
Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy., PMID:39048581
Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma., PMID:39052598
Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity., PMID:39075931
Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks., PMID:39215079
Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization., PMID:39287922
Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins., PMID:39455917
De novo biosynthesis of mogroside V by multiplexed engineered yeasts., PMID:39788182
Potential drug targets for asthma identified through mendelian randomization analysis., PMID:39806440
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis., PMID:40026415
Characterization of Exhausted T Cell Signatures in Pan-Cancer Settings., PMID:40076932
For research use only. Not for human or drug use.
