Catalog No.
PHJ56001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD299/CLEC4M (Leu241-Glu399).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
DC-SIGNR,DC-SIGN2,CLEC4M,DC-SIGN-related protein,C-type lectin domain family 4 member M,CD299,L-SIGN,CD209L,Liver/lymph node-specific ICAM-3-grabbing non-integrin,CD209L1,Dendritic cell-specific ICAM-3-grabbing non-integrin 2,CD209 antigen-like protein 1
Purification
Purified by antigen affinity column.
Accession
Q9H2X3
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D., PMID:39791910
Simultaneous Blockade of CD209 and CD209L by Monoclonal Antibody Does Not Provide Sufficient Protection Against Multiple Viral Infections In Vivo., PMID:39783143
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies., PMID:34464958
Immunohistochemical Study of SARS-CoV-2 Viral Entry Factors in the Cornea and Ocular Surface., PMID:32826650
[Comparative analysis of structural characteristics and epitopes in S proteins between SARS-CoV-2 and SARS-CoV]., PMID:32762171
Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors., PMID:29894153
CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection., PMID:24965233
Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses., PMID:23312596
Interaction of L-SIGN with hepatitis C virus envelope protein E2 up-regulates Raf-MEK-ERK pathway., PMID:23292357
Expression of the C-type lectins DC-SIGN or L-SIGN alters host cell susceptibility for the avian coronavirus, infectious bronchitis virus., PMID:22340967
HIV-1 infection of DC: evidence for the acquisition of virus particles from infected T cells by antigen uptake mechanism., PMID:19829715
Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells., PMID:18809735
The Immunobiology of SARS*., PMID:17243893
DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes., PMID:16839201
Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses., PMID:16365436
Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody., PMID:15878980
L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus., PMID:15371595
Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation., PMID:15254204
C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles., PMID:15166245
DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses., PMID:14581539
Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells., PMID:12186897
Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN., PMID:12083838
Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission., PMID:12021323
Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques., PMID:11799181
For research use only. Not for human or drug use.
