Catalog No.
PHG20701
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human EP300 (His2283-His2414).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Histone crotonyltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300,Histone acetyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,EP300,p300 HAT,Histone butyryltransferase p300,P300,E1A-associated protein p300
Purification
Purified by antigen affinity column.
Accession
Q09472
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement., PMID:40090010
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis., PMID:40010102
Comparison of cell type and disease subset chromatin modifications in SLE., PMID:39543716
Next-Generation Therapies for Multiple Myeloma., PMID:39364307
Multi-omics analysis and response prediction of PD-1 monoclonal antibody containing regimens in patients with relapsed/refractory diffuse large B-cell lymphoma., PMID:39358470
EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction in lipopolysaccharide-induced tubular epithelial cells., PMID:39230047
Discovery of natural multi-targets neuraminidase inhibitor glycosides compounds against influenza A virus through network pharmacology, virtual screening, molecular dynamics simulation, and in vitro experiment., PMID:37743355
DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia., PMID:37713484
Analysing transcriptomic signatures and identifying potential genes for the protective effect of inactivated COVID-19 vaccines., PMID:37096063
A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer., PMID:36951687
Deficiency of p53 Causes the Inadequate Expression of miR-1246 in B Cells of Systemic Lupus Erythematosus., PMID:36165173
CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses., PMID:35990699
Hypoxia-inducible factor pathway genes predict survival in metastatic clear cell renal cell carcinoma., PMID:35973929
Follicular lymphoma: The long and winding road leading to your cure?, PMID:35908982
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer., PMID:35064087
Simultaneous single-molecule detection of the acetyltransferase and crotonyltransferase activities of histone acetylation writer p300., PMID:34693944
High Throughput miRNA Screening Identifies miR-574-3p Hyperproductive Effect in CHO Cells., PMID:34439791
P300 Inhibition Improves Cell Apoptosis and Cognition Impairment Induced by Sevoflurane Through Regulating IL-17A Activation., PMID:34314911
Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas: A Series of 22 Cases Expanding the Spectrum of Transdifferentiation., PMID:34265801
Mapping the residue specificities of epigenome enzymes by yeast surface display., PMID:34186032
PDL1 high expression without TP53, KEAP1 and EPHA5 mutations could better predict survival for patients with NSCLC receiving atezolizumab., PMID:33246647
Production of fever mediator PGE2 in human monocytes activated with MDP adjuvant is controlled by signaling from MAPK and p300 HAT: Key role of T cell derived factor., PMID:33126082
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53., PMID:33097607
Clinical efficacy and molecular biomarkers in a phase II study of tucidinostat plus R-CHOP in elderly patients with newly diagnosed diffuse large B-cell lymphoma., PMID:33097085
Prevalence of Immunological Defects in a Cohort of 97 Rubinstein-Taybi Syndrome Patients., PMID:32594341
Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells., PMID:31678303
Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies., PMID:31669559
An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review., PMID:31662917
Sodium Tanshinone IIA Silate Alleviates High Glucose Induced Barrier Impairment of Human Retinal Pigment Epithelium through the Reduction of NF-κB Activation via the AMPK/p300 Pathway., PMID:31576759
Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G>T, p.(Gly1479*) and c.3474G>A, p.(Trp1158*) and missense c.4627G>T, p.(Asp1543Tyr) mutations., PMID:31491690
M7-FLIPI is not prognostic in follicular lymphoma patients with first-line rituximab chemo-free therapy., PMID:31423576
Ultrasensitive electrochemiluminescence immunosensor for the transcriptional co-activator p300 by using a graphene oxide monolayer and tetrahedral DNA-mediated signal amplification., PMID:31049723
Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools., PMID:30471702
New concepts in follicular lymphoma biology: From BCL2 to epigenetic regulators and non-coding RNAs., PMID:30360879
Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells., PMID:30293774
The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells., PMID:30135206
Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling., PMID:30066852
Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks., PMID:29789295
A Chemical Probe for Protein Crotonylation., PMID:29584949
Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors., PMID:29290942
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients., PMID:29194580
Chronic sun exposure is associated with distinct histone acetylation changes in human skin., PMID:29150847
Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort., PMID:28302137
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs., PMID:27742770
Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients., PMID:26857726
miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy., PMID:26718496
A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer., PMID:26695438
Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry., PMID:26256760
Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients., PMID:25806092
Detecting key genes regulated by miRNAs in dysfunctional crosstalk pathway of myasthenia gravis., PMID:25705681
For research use only. Not for human or drug use.
