Catalog No.
PHF99501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TAP1 (Tyr525-Glu808).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TAP1,APT1,Peptide transporter involved in antigen processing 1,Really interesting new gene 4 protein,Peptide transporter TAP1,Peptide transporter PSF1,RING4,Antigen peptide transporter 1,PSF-1,ABCB2,Y3,Peptide supply factor 1,PSF1,ATP-binding cassette sub-family B member 2
Purification
Purified by antigen affinity column.
Accession
Q03518
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
TAP1 promotes immune escape by activating JNK/STAT1/PD-L1 signaling in EBV-associated gastric cancer., PMID:40500531
IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer., PMID:40091029
PMN-MDSCs are responsible for immune suppression in anti-PD-1 treated TAP1 defective melanoma., PMID:39825997
Autophagy Blockage Up-Regulates HLA-Class-I Molecule Expression in Lung Cancer and Enhances Anti-PD-L1 Immunotherapy Efficacy., PMID:39409895
Clinical efficacy and biomarker analysis of neoadjuvant camrelizumab plus chemotherapy for early-stage triple-negative breast cancer: a experimental single-arm phase II clinical trial pilot study., PMID:38116673
Protein-Protein Interactions: Co-immunoprecipitation., PMID:37930535
Tissue proteome analysis revealed an association between cancer, immune system response, and the idiopathic granulomatous mastitis., PMID:36175807
Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice., PMID:35911713
Human Papillomavirus 16 E6 Suppresses Transporter Associated with Antigen-Processing Complex in Human Tongue Keratinocyte Cells by Activating Lymphotoxin Pathway., PMID:35454851
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRV., PMID:35343384
Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial., PMID:35013615
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients., PMID:32923135
Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer., PMID:32847480
Immune characterization of metastatic colorectal cancer patients post reovirus administration., PMID:32552875
Histocompatibility Complex Status and Mendelian Randomization Analysis in Unsolved Antibody Deficiency., PMID:32038658
Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter., PMID:31817841
An Unbiased Immunoaffinity-Based Strategy for Profiling Covalent Drug Targets In Vivo., PMID:31743002
Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma., PMID:31686124
The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins., PMID:29879547
Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83., PMID:29793955
HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers., PMID:29362132
IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells., PMID:29020964
IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species., PMID:28477473
RNA Seq analysis for transcriptome profiling in response to classical swine fever vaccination in indigenous and crossbred pigs., PMID:28361233
Single nucleotide polymorphisms in the FcγR3A and TAP1 genes impact ADCC in cynomolgus monkey PBMCs., PMID:28154890
Absence of miR-182 Augments Cardiac Allograft Survival., PMID:27893611
CD137 Stimulation Enhances Cetuximab-Induced Natural Killer: Dendritic Cell Priming of Antitumor T-Cell Immunity in Patients with Head and Neck Cancer., PMID:27496866
Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients., PMID:27484791
STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients., PMID:25972070
β2-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system., PMID:25702838
Targeted delivery of an antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis., PMID:24155957
Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris)., PMID:23892057
Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity., PMID:23588237
Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii., PMID:23558133
Rescue of MHC-1 antigen processing machinery by down-regulation in expression of IGF-1 in human glioblastoma cells., PMID:23526983
Possible role of mural cell-covered mature blood vessels in inducing drug resistance in cancer-initiating cells., PMID:23473746
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients., PMID:23444227
Protein interaction and cellular localization of human CDC45., PMID:23364835
Mobilization of regulatory T cells in response to carotid injury does not influence subsequent neointima formation., PMID:23240042
Loss of heterozygosity at 6p21 and HLA class I expression in esophageal squamous cell carcinomas in China., PMID:22320985
Localization, expression change in PRRSV infection and association analysis of the porcine TAP1 gene., PMID:22211104
Bovine herpesvirus type 1 (BHV-1) UL49.5 luminal domain residues 30 to 32 are critical for MHC-I down-regulation in virus-infected cells., PMID:22046246
Different expression levels of the TAP peptide transporter lead to recognition of different antigenic peptides by tumor-specific CTL., PMID:22025554
Methylation of the promoter of human leukocyte antigen class I in human esophageal squamous cell carcinoma and its histopathological characteristics., PMID:21335133
Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex., PMID:21108342
[Paclitaxel blocks immunologic escape through up-regulating TAP-1, TAP-2 and eliminatiing Treg cells in 3LL-bearing mice]., PMID:20959065
Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype., PMID:19815810
Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas., PMID:19756593
A novel role of HLA class I in the pathology of medulloblastoma., PMID:19594892
Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer., PMID:19243813
For research use only. Not for human or drug use.
