Catalog No.
PHE43601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD158b2/KIR2DL3 (His22-Pro341).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
NKAT2b,KIR2DL3,p58 natural killer cell receptor clone CL-6,p58.2 MHC class-I-specific NK receptor,CD158 antigen-like family member B2,MHC class I NK cell receptor,KIR-023GB,Killer inhibitory receptor cl 2-3,p58 NK receptor CL-6,CD158b2,Killer cell immunoglobulin-like receptor 2DL3,Natural killer-associated transcript 2,CD158B2,KIRCL23,NKAT-2,NKAT2a,NKAT2
Purification
Purified by antigen affinity column.
Accession
P43628
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Missing Self-Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study., PMID:34301794
Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1., PMID:34017328
The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans., PMID:31613998
Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC., PMID:30698860
A novel antibody combination to identify KIR2DS2high natural killer cells in KIR2DL3/L2/S2 heterozygous donors., PMID:30381896
KIR downregulation by IL-12/15/18 unleashes human NK cells from KIR/HLA-I inhibition and enhances killing of tumor cells., PMID:29105756
NK Cells Expressing the Inhibitory Killer Immunoglobulin-Like Receptors (iKIR) KIR2DL1, KIR2DL3 and KIR3DL1 Are Less Likely to Be CD16+ than Their iKIR Negative Counterparts., PMID:27732638
Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general., PMID:25037176
[Effects of blocking inhibitory KIR receptors on cytotoxic activity of human NK cells in vitro]., PMID:21984148
A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection., PMID:21600205
Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining., PMID:20525888
B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression., PMID:20056126
Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies., PMID:19740374
Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes., PMID:18292496
Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation., PMID:18158964
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils., PMID:16254138
Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2., PMID:15314042
Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma., PMID:14562047
Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors., PMID:11470774
TCR gamma delta cytotoxic T lymphocytes expressing the killer cell-inhibitory receptor p58.2 (CD158b) selectively lyse acute myeloid leukemia cells., PMID:11438826
Differential disappearance of inhibitory natural killer cell receptors during HAART and possible impairment of HIV-1-specific CD8 cytotoxic T lymphocytes., PMID:11399978
Tumor cells regulate the lytic activity of tumor-specific cytotoxic t lymphocytes by modulating the inhibitory natural killer receptor function., PMID:11309272
Non-MHC-restricted CD4+ T lymphocytes are regulated by HLA-Cw7-mediated inhibition., PMID:11163077
Altered expression of natural killer cell inhibitory receptors (KIRs) on T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients., PMID:10746261
Monoclonal antibodies with various reactivity to p58 killer inhibitory receptors., PMID:10626681
Natural killer cell-mediated recognition of human trophoblast., PMID:10092546
Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors., PMID:9378975
p46, a novel natural killer cell-specific surface molecule that mediates cell activation., PMID:9314561
The killer cell inhibitory receptor genomic region on human chromosome 19q13.4., PMID:9234476
A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation., PMID:8765026
The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer., PMID:8760804
The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function., PMID:8630400
Physical and functional independency of p70 and p58 natural killer (NK) cell receptors for HLA class I: their role in the definition of different groups of alloreactive NK cell clones., PMID:8643653
Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells., PMID:7650491
Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains., PMID:7749980
For research use only. Not for human or drug use.
