Anti-TGFBR1 Polyclonal Antibody

Catalog No.

PHE19401

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TGFBR1 (Leu34-Glu125).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Activin receptor-like kinase 5,ALK-5,TGFBR1,TGFR-1,ALK5,Transforming growth factor-beta receptor type I,TGF-beta type I receptor,TbetaR-I,SKR4,Activin A receptor type II-like protein kinase of 53kD,TGF-beta receptor type I,TGF-beta receptor type-1,Serine/threonine-protein kinase receptor R4

Purification

Purified by antigen affinity column.

Accession

P36897

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Mechanistic insights into Schisandrin C as the active anti-renal fibrosis ingredient of Schisandra chinensis: a network pharmacology analysis and transcriptomics integrated experimental verification., PMID:40500382

Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells., PMID:40148545

Discovery of HM-279, a Potent Inhibitor of ALK5 for Improving Therapeutic Efficacy of Cancer Immunotherapy., PMID:40108955

Identification of TGFBR1 Gene Variants in Two Chinese Pedigrees with Loeys-Dietz Syndrome., PMID:39937695

Lumican/Lumikine Promotes Healing of Corneal Epithelium Debridement by Upregulation of EGFR Ligand Expression via Noncanonical Smad-Independent TGFβ/TBRs Signaling., PMID:39404363

Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601

Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response., PMID:39046874

Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta., PMID:38744219

TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation., PMID:38441961

Maternal diet during gestation affect prostatic tissue component in SHR/Izm offspring., PMID:38032025

GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model., PMID:37904673

TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies., PMID:37718518

The Identification and Clinical Value Evaluation of CYCS Related to Asthma through Bioinformatics Analysis and Functional Experiments., PMID:37091894

Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion., PMID:36343916

PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II., PMID:35139382

Hyper-IgE syndrome, 2021 update., PMID:34419355

Tofacitinib Ameliorates Lupus Through Suppression of T Cell Activation Mediated by TGF-Beta Type I Receptor., PMID:34394075

Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma., PMID:33811482

Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer., PMID:33688022

Single nucleotide variants in immune-response genes and the tumor microenvironment composition predict progression of mantle cell lymphoma., PMID:33648463

Polymorphisms in MicroRNA Target Sites of TGF-β Signaling Pathway Genes and Susceptibility to Allergic Rhinitis., PMID:33596578

circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling., PMID:33545359

Micellar Casein and Whey Powder Hold a TGF-β Activity and Regulate ID Genes In Vitro., PMID:33477984

The epigenetic treatment remodel genome-wide histone H4 hyper-acetylation patterns and affect signaling pathways in acute promyelocytic leukemia cells., PMID:33045196

Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner., PMID:32977155

TGFβ-Directed Therapeutics: 2020., PMID:32835827

Transforming growth factor beta orchestrates PD-L1 enrichment in tumor-derived exosomes and mediates CD8 T-cell dysfunction regulating early phosphorylation of TCR signalome in breast cancer., PMID:32832992

PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis., PMID:32482644

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?, PMID:32143707

The relation between anti-TGBFR1 immunohistochemical reaction and low Ki67, small tumor size and high estrogen receptor expression in invasive breast cancer., PMID:32103597

Deficient Regulatory Innate Lymphoid Cells and Differential Expression of miRNAs in Acute Myeloid Leukemia Quantified by Next Generation Sequence., PMID:32099460

Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1., PMID:32066676

miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1., PMID:31734320

TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration., PMID:31514337

TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone., PMID:31506281

Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors., PMID:31434718

Anaplastic lymphoma kinase 5A4 immunohistochemistry as a diagnostic assay in lung cancer: A Canadian reference testing center's results in population-based reflex testing., PMID:31390053

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation., PMID:31290007

Breast Cancer Stem Cells with Tumor- versus Metastasis-Initiating Capacities Are Modulated by TGFBR1 Inhibition., PMID:31257133

Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling., PMID:31171625

Combination Therapy for Treating Advanced Drug-Resistant Acute Lymphoblastic Leukemia., PMID:31138521

Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer., PMID:30979739

A Combination Therapy Targeting Endoglin and VEGF-A Prevents Subretinal Fibro-Neovascularization Caused by Induced Müller Cell Disruption., PMID:30592496

Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic Stroke., PMID:30208313

Hyaluronan antagonizes the differentiation effect of TGF-β1 on nasal epithelial cells through down-regulation of TGF-β type I receptor., PMID:30032656

Inhibition of SRC family kinases facilitates anti-CTLA4 immunotherapy in head and neck squamous cell carcinoma., PMID:29955905

Trastuzumab inhibits pituitary tumor cell growth modulating the TGFB/SMAD2/3 pathway., PMID:29875136

Autoimmune Retinopathy: An Immunologic Cellular-Driven Disorder., PMID:29721944

Specific blockade CD73 alters the "exhausted" phenotype of T cells in head and neck squamous cell carcinoma., PMID:29663369

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation., PMID:29577978

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