Catalog No.
PHA09301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ARNTL (Glu48-Leu320).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Basic-helix-loop-helix-PAS protein MOP3,ARNTL,Member of PAS protein 3,PAS domain-containing protein 3,BMAL1,Aryl hydrocarbon receptor nuclear translocator-like protein 1,BHLHE5,Class E basic helix-loop-helix protein 5,bHLHe5,MOP3,Brain and muscle ARNT-like 1,bHLH-PAS protein JAP3,PASD3
Purification
Purified by antigen affinity column.
Accession
O00327
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Disruption of thyroid-intrinsic clock aggravates experimental autoimmune thyroiditis., PMID:39998446
Chronological Effects of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer., PMID:39777632
The circadian clock gene BMAL1 modulates autoimmunity features in lupus., PMID:39664388
Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation., PMID:39064706
Silencing BMAL1 promotes M1/M2 polarization through the LDHA/lactate axis to promote GBM sensitivity to bevacizumab., PMID:38733825
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions., PMID:38509675
The rhythms of histones in regeneration: The epigenetic modifications determined by clock genes., PMID:38284199
Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression., PMID:38035406
Deficiency of BMAL1 promotes ROS generation and enhances IgE-dependent degranulation in mast cells., PMID:38000295
Circadian clock disruption in autoimmune thyroiditis., PMID:37548297
Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism., PMID:36054336
Improved locomotor recovery after contusive spinal cord injury in Bmal1-/- mice is associated with protection of the blood spinal cord barrier., PMID:32848194
The circadian clock protects against ferroptosis-induced sterile inflammation., PMID:32115146
Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A., PMID:31300350
The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis., PMID:30612576
Sex-Dependent Effects of Bmal1-Deficiency on Mouse Cerebral Cortex Infarction in Response to Photothrombotic Stroke., PMID:30314381
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis., PMID:29996098
Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML., PMID:27383066
CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice., PMID:27035655
Ras Activity Oscillates in the Mouse Suprachiasmatic Nucleus and Modulates Circadian Clock Dynamics., PMID:25762011
Brain and muscle Arnt-like 1 promotes skeletal muscle regeneration through satellite cell expansion., PMID:25218946
Epigenetic suppression of mouse Per2 expression in the suprachiasmatic nucleus by the inhalational anesthetic, sevoflurane., PMID:24498074
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma., PMID:22510946
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies., PMID:19861541
Localization of circadian clock protein BMAL1 in the photoperiodic signal transduction machinery in Japanese quail., PMID:19760601
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription., PMID:19414601
MOP3, a component of the molecular clock, regulates the development of B cells., PMID:16925591
Distribution of circadian clock-related proteins in the cephalic nervous system of the silkworm, Bombyx mori., PMID:15523109
The role of phosphorylation and degradation of hPER protein oscillation in normal human fibroblasts., PMID:14712925
Expression of circadian rhythm genes in gonadotropin-releasing hormone-secreting GT1-7 neurons., PMID:12960008
Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus., PMID:12859345
Light and glutamate-induced degradation of the circadian oscillating protein BMAL1 during the mammalian clock resetting., PMID:11027210
Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family., PMID:9585435
For research use only. Not for human or drug use.
