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Research Grade Isatuximab

Catalog #:   DHD80802 Specific References (100) DATASHEET
Host species: Chimeric
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD80802

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Chimeric

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Cyclic ADP-ribose hydrolase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, T10, 2'-phospho-cyclic-ADP-ribose transferase, CD38, ADPRC 1, ADP-ribosyl cyclase 1, 2'-phospho-ADP-ribosyl cyclase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P28907

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

SAR-650984, hu38SB19, CAS: 1461640-62-9

Clone ID

Isatuximab

Data Image
  • Bioactivity
    Detects Human CD38 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Isatuximab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study, PMID: 31735560

Isatuximab for the treatment of relapsed/refractory multiple myeloma, PMID: 33111607

Isatuximab: First Approval, PMID: 32347476

Isatuximab plus carfilzomib/dexamethasone versus carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma: IKEMA Phase III study design, PMID: 31833394

Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab, PMID: 31779273

The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma, PMID: 30692097

Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells, PMID: 32922390

Isatuximab monotherapy in relapsed/refractory multiple myeloma: A Japanese, multicenter, phase 1/2, safety and efficacy study, PMID: 32975869

A phase 1b study of isatuximab plus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma, PMID: 30862646

Isatuximab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma patients with renal impairment: ICARIA-MM subgroup analysis, PMID: 32444867

Isatuximab, PMID: 32697463

Isatuximab plus pomalidomide/dexamethasone versus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma: ICARIA Phase III study design, PMID: 29268619

Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis, PMID: 32586908

Isatuximab as monotherapy and combined with dexamethasone in patients with relapsed/refractory multiple myeloma, PMID: 33080623

Antibodies to watch in 2020, PMID: 31847708

Therapeutic potential of isatuximab in the treatment of multiple myeloma: Evidence to date, PMID: 32446599

Correction to: Isatuximab: First Approval, PMID: 32447610

Incorporating isatuximab in the treatment of multiple myeloma, PMID: 31735559

Phase I trial of isatuximab monotherapy in the treatment of refractory multiple myeloma, PMID: 30926770

Isatuximab: A Review of Its Use in Multiple Myeloma, PMID: 34351561

Immune-based therapies in the management of multiple myeloma, PMID: 32829378

Drug-Disease Interaction and Time-Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients, PMID: 33021075

Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy, PMID: 30858549

CD38 antibodies in multiple myeloma: back to the future, PMID: 29118010

Emerging agents and regimens for multiple myeloma, PMID: 33168044

Antibodies to watch in 2019, PMID: 30516432

Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond, PMID: 29257139

Dexamethasone as a partner of isatuximab, PMID: 33661291

Resistance Mechanisms Towards CD38-Directed Antibody Therapy in Multiple Myeloma, PMID: 32331242

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma, PMID: 32054831

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma, PMID: 28249894

CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance, PMID: 30294326

Monoclonal antibodies targeting CD38 in hematological malignancies and beyond, PMID: 26864107

Immunomodulatory effects of CD38-targeting antibodies, PMID: 29702148

Monoclonal and Bispecific Anti-BCMA Antibodies in Multiple Myeloma, PMID: 32961764

A dose-finding Phase 2 study of single agent isatuximab (anti-CD38 mAb) in relapsed/refractory multiple myeloma, PMID: 32409691

A phase 1b study of isatuximab plus lenalidomide and dexamethasone for relapsed/refractory multiple myeloma, PMID: 28483761

Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial, PMID: 34097854

Isatuximab plus pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma according to prior lines of treatment and refractory status: ICARIA-MM subgroup analysis, PMID: 33839618

Multiple Myeloma: Clinical Updates From the American Society of Hematology Annual Meeting 2018, PMID: 31076371

In vivo vaccination effect in multiple myeloma patients treated with the monoclonal antibody isatuximab, PMID: 31409922

Evaluation of Preclinical Activity of Isatuximab in Patients with Acute Lymphoblastic Leukemia, PMID: 34376579

EMA Review of Isatuximab in Combination with Pomalidomide and Dexamethasone for the Treatment of Adult Patients with Relapsed and Refractory Multiple Myeloma, PMID: 34213061

Tafasitamab, PMID: 33355731

PK/PD modeling analysis for dosing regimen selection of isatuximab as single agent and in combination therapy in patients with multiple myeloma, PMID: 34185964

Blood Transfusion Management for Patients Treated With Anti-CD38 Monoclonal Antibodies, PMID: 30498492

Treatment of relapsed/refractory multiple myeloma in the bortezomib and lenalidomide era: a systematic review and network meta-analysis, PMID: 33432438

Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma, PMID: 34024861

SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide, PMID: 26338273

Isatuximab plus pomalidomide and dexamethasone in frail patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis, PMID: 34383345

Risk adapted therapy for newly diagnosed multiple myeloma delivered through local cytogenetic laboratories in a National Clinical Trial: UKMRA RADAR study., PMID:40530259

Thromboembolism in transplant-ineligible multiple myeloma patients on triplet/quadruplet therapy: a post-hoc analysis of BENEFIT., PMID:40523501

CD38-targeted antibody-polymer drug conjugates for enhanced treatment of multiple myeloma., PMID:40516447

Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma., PMID:40493883

Global Access to Multiple Myeloma Therapies., PMID:40466014

Isatuximab Subcutaneous by On-Body Delivery System vs Isatuximab Intravenous Plus Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Phase 3 IRAKLIA Study., PMID:40459178

Measurable Residual Disease-Guided Therapy in Newly Diagnosed Myeloma., PMID:40459097

Functional multiomics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma., PMID:40453054

The utility of intravenous immunoglobulin infection prophylaxis in patients on anti-CD38 therapies., PMID:40452474

Real-world outcomes of isatuximab with pomalidomide and dexamethasone for relapsed and/or refractory multiple myeloma., PMID:40437669

Analysis of pharmacotherapeutic approaches for multiple myeloma and correlated renal and pulmonary impairments: a retrospective real-world registry study in the Greater Gulf Region (REPAIR Study)., PMID:40416867

Isatuximab, Carfilzomib, and Dexamethasone Combined With Late Autologous Stem Cell Transplantation: A Synergistic Strategy for First Relapse Multiple Myeloma., PMID:40387425

Practice-changing updates on multiple myeloma: highlights from the 2024 ASH annual meeting., PMID:40361170

Comparative Efficacy of Ciltacabtagene Autoleucel Versus Standard-of-Care Treatments for Patients with Previously Treated Relapsed or Refractory Multiple Myeloma: A Matching-Adjusted Indirect Comparison., PMID:40354013

Relapsed/refractory multiple myeloma: standard of care management of patients in the Gulf region., PMID:40352314

Beyond the Hydrashift assay: the utility of isoelectric focusing for therapeutic antibody and paraprotein detection., PMID:40305408

Pulmonary adverse events associated with monoclonal antibodies approved for multiple myeloma: a pharmacovigilance study based on the FDA adverse event reporting system., PMID:40302414

Efficacy and Safety of Isatuximab, Carfilzomib, and Dexamethasone (IsaKd) in Multiple Myeloma Patients at the First Relapse After Autologous Stem Cell Transplantation and Lenalidomide Maintenance: Results from the Multicenter, Real-Life AENEID Study., PMID:40284030

Consensus Guidelines and Recommendations for The CD38 Monoclonal Antibody-based Quadruplet Therapy and Management in Clinical Practice for Newly Diagnosed Multiple Myeloma: From the Pan-Pacific Multiple Myeloma Working Group., PMID:40271095

Efficacy and safety of isatuximab monotherapy to treat relapsed or refractory multiple myeloma: a pooled analysis of clinical trials., PMID:40257476

The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse., PMID:40241199

Efficacy and Safety of Quadruplet Therapy in Newly Diagnosed Transplant-Eligible Multiple Myeloma: A Systematic Review and Meta-Analysis., PMID:40176408

Belantamab Mafodotin Plus Proteasome Inhibition Efficacy Versus Comparators in Early Relapsed Myeloma: A Systematic Review and Network Meta-Analysis., PMID:40143674

A systematic review and meta-analysis of phase III randomized controlled trials to assess the risk of pneumonia, URTIs, and VTE in multiple myeloma patients treated with isatuximab., PMID:40124649

PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs; approval of atezolizumab for alveolar soft part sarcoma, epcoritamab for follicular lymphoma, and isatuximab for multiple myeloma in Japan., PMID:40117081

Isatuximab plus bortezomib, lenalidomide, and dexamethasone for transplant-ineligible newly diagnosed multiple myeloma patients: a frailty subgroup analysis of the IMROZ trial., PMID:40109195

Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System., PMID:40095047

Cost-effectiveness analysis of combination therapies involving novel agents for first/second-relapse patients with multiple myeloma: a Markov model approach with calibration techniques., PMID:40088315

How First-Line Therapy is Changing in Transplant-Eligible Multiple Myeloma Patients., PMID:40084095

Efficacy of Combined CD38 and PD1 Inhibition with Isatuximab and Cemiplimab for Relapsed/Refractory NK/T-Cell Lymphoma., PMID:40073374

Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomidedexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data., PMID:40045883

Third-line multiple myeloma treatment of inpatients in a German cancer center: analysis of potential cost savings due to decreased renal insufficiency., PMID:40045293

Minimal Residual Disease Significance in Multiple Myeloma Patients Treated with Anti-CD38 Monoclonal Antibodies., PMID:40005973

Monoclonal Antibodies in Relapsed-Refractory Multiple Myeloma., PMID:40005960

Real-World Safety and Tolerability of Rapid, 30-Minutes, Intravenous Isatuximab in Patients With Multiple Myeloma., PMID:40000356

Evaluation of anti-CD38 monoclonal antibody-based immunotherapy in multiple myeloma with renal insufficiency: a systematic review and meta-analysis., PMID:39963097

Frontline management of multiple myeloma patients: optimizing treatment for patients in the Gulf region., PMID:39944235

Monoclonal Antibodies and Small-Molecule Inhibitors Associated Osteonecrosis of Jaw: A Retrospective Pharmacovigilance Study., PMID:39922223

Isatuximab, bortezomib, lenalidomide, and limited dexamethasone in patients with transplant-ineligible multiple myeloma (REST): a multicentre, single-arm, phase 2 trial., PMID:39909655

Efficacy and Prognostic Indicators of Isatuximab, Pomalidomide, and Dexamethasone (IsaPd) in Daratumumab-Refractory Multiple Myeloma Patients: A Multicenter Real-World Study., PMID:39898517

Isatuximab-Based Therapy for Multiple Myeloma. Reply., PMID:39879605

Isatuximab-Based Therapy for Multiple Myeloma., PMID:39879604

A plain language summary of the ICARIA study, comparing isatuximab-pomalidomide- dexamethasone with pomalidomide- dexamethasone in people with multiple myeloma., PMID:39851267

Characteristics and treatment patterns in patients with multiple myeloma in Japan: A retrospective cohort analysis., PMID:39847579

Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone Induction in Newly Diagnosed Myeloma: Analysis of the MIDAS Trial., PMID:39841461

Evolution of frontline treatment for multiple myeloma: clinical investigation of quadruplets containing carfilzomib and anti-CD38 monoclonal antibodies., PMID:39774926

Isatuximab (Sarclisa) for multiple myeloma., PMID:39752726

Advancements in the Treatment of Multiple Myeloma., PMID:39744254

Comprehensive safety evaluation of isatuximab in multiple myeloma using disproportionality analysis of FAERS and meta-analysis of randomized controlled trials., PMID:39738354

Isatuximab plus pomalidomide and dexamethasone in frail individuals with relapsed/refractory multiple myeloma in Japan., PMID:39729222

Datasheet

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Research Grade Isatuximab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Isatuximab [DHD80802]
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