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Research Grade Teprotumumab

Catalog #:   DHC29903 Specific References (101) DATASHEET
Host species: Human
Isotype: IgG1-nd
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC29903

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-nd

Clonality

Monoclonal

Target

CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P08069

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

RO4858696-000, CAS: 1036734-93-6

Clone ID

Teprotumumab

Data Image
  • Bioactivity
    Detects Human CD221/IGF1R in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Teprotumumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Teprotumumab: First Approval, PMID: 32157641

Teprotumumab for the Treatment of Active Thyroid Eye Disease, PMID: 31971679

Teprotumumab for Thyroid-Associated Ophthalmopathy, PMID: 28467880

Teprotumumab: a novel therapeutic monoclonal antibody for thyroid-associated ophthalmopathy, PMID: 32429706

Teprotumumab as a Novel Therapy for Thyroid-Associated Ophthalmopathy, PMID: 33391187

Teprotumumab in Thyroid-Associated Ophthalmopathy: Rationale for Therapeutic Insulin-Like Growth Factor-I Receptor Inhibition, PMID: 32040069

Teprotumumab for the treatment of thyroid eye disease, PMID: 32707005

Teprotumumab for Thyroid Eye Disease, PMID: 32205652

Teprotumumab for Active Thyroid Eye Disease, PMID: 32402171

Teprotumumab for Active Thyroid Eye Disease, PMID: 32402170

Teprotumumab for non-inflammatory thyroid eye disease (TED): evidence for increased IGF-1R expression, PMID: 33221815

Teprotumumab reduces extraocular muscle and orbital fat volume in thyroid eye disease, PMID: 33172865

[Teprotumumab for thyroid-associated ophthalmopathy : OPTIC], PMID: 33025123

Antibodies to watch in 2020, PMID: 31847708

Teprotumumab for Active Thyroid Eye Disease. Reply, PMID: 32402172

Teprotumumab: a disease modifying treatment for graves' orbitopathy, PMID: 32636936

Thyroid-associated ophthalmopathy: Emergence of teprotumumab as a promising medical therapy, PMID: 32088116

Treatment of Graves' ophthalmopathy, PMID: 33069387

Teprotumumab in Clinical Practice: Recommendations and Considerations From the OPTIC Trial Investigators, PMID: 33417417

Teprotumumab, PMID: 34292697

Teprotumumab (Tepezza): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment, PMID: 33481154

Teprotumumab, PMID: 33886177

Early experience with teprotumumab for chronic thyroid eye disease, PMID: 32462101

[Teprotumumab - selective IGF-1-receptor blockade improves significantly endocrine opthalmopathy in Basedow's disease], PMID: 32392608

Teprotumumab for Dysthyroid Optic Neuropathy: Early Response to Therapy, PMID: 32976335

Current and Emerging Treatment Strategies for Graves' Orbitopathy, PMID: 30659423

Antibodies to watch in 2019, PMID: 30516432

Medical treatment in thyroid eye disease in 2020, PMID: 32447327

Ototoxicity and Teprotumumab, PMID: 34448414

New insights into the pathogenesis and nonsurgical management of Graves orbitopathy, PMID: 31889140

Teprotumumab, an insulin-like growth factor-1 receptor antagonist antibody, in the treatment of active thyroid eye disease: a focus on proptosis, PMID: 30575804

A New Era in the Treatment of Thyroid Eye Disease, PMID: 31377284

Current and Future Treatments for Graves' Disease and Graves' Ophthalmopathy, PMID: 30286486

Teprotumumab for Optic Neuropathy in Thyroid Eye Disease, PMID: 33270090

Teprotumumab for thyroid eye disease: early response is not required for benefit, PMID: 34183792

Resolution of pretibial myxedema with teprotumumab in a patient with Graves disease, PMID: 33294564

Teprotumumab: Interpreting the Clinical Trials in the Context of Thyroid Eye Disease Pathogenesis and Current Therapies, PMID: 33930408

Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy, PMID: 30215690

Teprotumumab Treatment for Thyroid-Associated Ophthalmopathy, PMID: 33511083

Graves' disease: Clinical manifestations, immune pathogenesis (cytokines and chemokines) and therapy, PMID: 32059832

Advances in treatment of active, moderate-to-severe Graves' ophthalmopathy, PMID: 27346786

[Update Graves' disease 2019], PMID: 30703831

Current Understanding of the Progression and Management of Thyroid Associated Orbitopathy: A Systematic Review, PMID: 31823232

Teprotumumab and Hearing Loss: Case Series and Proposal for Audiologic Monitoring, PMID: 34085994

Graves’ Disease: Complications, PMID: 25905406

Teprotumumab for chronic thyroid eye disease, PMID: 34060414

Immunotherapies for thyroid eye disease, PMID: 31356255

Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes, PMID: 24878056

Novel therapies for thyroid autoimmune diseases: An update, PMID: 31813786

Teprotumumab for patients with active thyroid eye disease: a pooled data analysis, subgroup analyses, and off-treatment follow-up results from two randomised, double-masked, placebo-controlled, multicentre trials, PMID: 33865501

TSHR-targeting nucleic acid aptamer treats Graves' ophthalmopathy via novel allosteric inhibition. [DHC29903]

Case Report: Development of severe inflammatory orbitopathy after immune checkpoint inhibitor initiation., PMID:40529668

Teprotumumab in the management of thyroid eye disease mechanistic insights and adverse reactions: a comprehensive review., PMID:40496563

Persistent Palmar Rash Associated with Teprotumumab Treatment., PMID:40488249

Regional Differences in the Management of Thyroid Eye Disease: Results from an International Clinical Practice Survey of Endocrinologists., PMID:40432588

Comparative efficacy and safety of rituximab, tocilizumab, and teprotumumab in Graves' orbitopathy: a systematic review and meta-analysis., PMID:40404973

Long-term Cardiovascular, Renal, and Safety Outcomes of Teprotumumab versus Systemic Glucocorticoids in Thyroid Eye Disease: A Target Trial Emulation., PMID:40398692

Thyroid eye disease in the biologic era: a 40-year paradigm shift in nonsurgical therapeutic strategies., PMID:40397653

Teprotumumab Use in Thyroid Eye Disease: Clinical Outcomes in the United Arab Emirates- a First Regional Case Series., PMID:40396469

Time to improvement following teprotumumab treatment of thyroid eye disease: real world experience., PMID:40366381

LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy., PMID:40340927

Thyroid eye disease (Graves' orbitopathy): clinical presentation, epidemiology, pathogenesis, and management., PMID:40324443

Thyroid-related orbitopathy: clinical overview, novel medical treatments and the role of orbital surgery., PMID:40317422

Statins and Thyroid Eye Disease: A Propensity Score-Matched Retrospective Cohort Analysis., PMID:40309510

Efficacy and safety of Tocilizumab for thyroid eye disease: a systemic review and Meta-analysis., PMID:40304985

Teprotumumab Improves Quality of Life in Thyroid Eye Disease: Meta-analysis and Matching-adjusted Indirect Comparison., PMID:40303547

Orbital Decompression in the Biologic Era: Is There Still a Need for Surgery?, PMID:40299895

The role of IL-6 in thyroid eye disease: an update on emerging treatments., PMID:40297767

Drug-induced hearing loss: a real-world pharmacovigilance study using the FDA adverse event reporting system database., PMID:40188564

Targeted immunotherapies for Graves' thyroidal & orbital diseases., PMID:40145088

Multiple pseudoprogressions during ongoing immunotherapy-based treatment of advanced gastric neuroendocrine carcinoma: A case report and review of literature., PMID:40092963

Spectral-domain optical coherence tomography imaging findings in patients receiving teprotumumab for thyroid eye disease., PMID:40083365

Nationwide orbital decompression volume, surgical approach, and subspecialty distribution patterns within the center for medicare and medicaid services population in the era of teprotumumab., PMID:40079573

Efficacy and Safety of Teprotumumab in Thyroid Eye Disease: A Systematic Review and Meta-Analysis., PMID:39952471

Otologic Symptoms Following Teprotumumab Administration in Patients with Thyroid Eye Disease., PMID:39951668

Thyroid dermopathy and thyroid eye disease associated with hypofunctional autoimmune thyroid disease with high TSI/anti-TSHR antibodies improved with teprotumumab., PMID:39950657

Controversies Surrounding IGF-I Receptor Involvement in Thyroid-Associated Ophthalmopathy., PMID:39909461

A randomised, double-masked, placebo-controlled trial evaluating the efficacy and safety of teprotumumab for active thyroid eye disease in Japanese patients., PMID:39896230

Novel perspectives on the pharmacological treatment of thyroid-associated ophthalmopathy., PMID:39872310

Re: Ugradar et al.: The rate of re-treatment in patients treated with teprotumumab: a multicenter study of 119 patients with 1 year of follow-up (Ophthalmology. 2025;132:92-97)., PMID:39818625

Observational Characterization of the Retreatment Course of Patients With Thyroid Eye Disease., PMID:39780310

Reply Re: "Teprotumumab for the Treatment of Recalcitrant Thyroid Eye Disease"., PMID:39752221

Re: "Teprotumumab for the Treatment of Recalcitrant Thyroid Eye Disease"., PMID:39752220

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells., PMID:39723207

Clinical and Radiologic Predictors of Response to Teprotumumab: A 3D Volumetric Analysis of 35 Patients., PMID:39714282

Efficacy, Safety, and Recurrence in Older Thyroid Eye Disease Patients Undergoing Teprotumumab Treatment., PMID:39704303

Epidemiology and Management of Moderate to Severe Thyroid Eye Disease in the United States: Analysis of a Healthcare Claims Database., PMID:39690929

Comprehensive Comparisons of Different Treatments for Active Graves Orbitopathy: A Systematic Review and Bayesian Model-Based Network Meta-Analysis., PMID:39680569

Risk of audiologic side effects with teprotumumab treatment for thyroid eye disease: propensity matched analysis., PMID:39668181

Surgical Timing for Patients With Thyroid Eye Disease Treated With Teprotumumab: A Collaborative Multicenter Study., PMID:39656059

Teprotumumab versus intravenous methylprednisolone in thyroid eye disease: A systematic review., PMID:39651498

Advances of IGF-1R inhibitors in Graves' ophthalmopathy., PMID:39578269

Teprotumumab's Impact on Proptosis in Long-duration Thyroid Eye Disease: A Systematic Review and Meta-analysis., PMID:39526058

Recent advances in neuro-ophthalmology., PMID:39462921

Teprotumumab for the Treatment of Thyroid Eye Disease: Why Should We Keep Our Eyes "Wide Open"?-A Clinical and Pharmacovigilance Point of View., PMID:39452535

[Survey of the management of moderate to severe active Graves' orbitopathy at 28 metropolitan centers of excellence in France]., PMID:39368261

The Impact of Monoclonal Antibody Usage on Hearing Outcomes: A Systematic Review., PMID:39268884

Reply Re: "Proptosis Regression After Teprotumumab Treatment for Thyroid Eye Disease"., PMID:39240200

Re: "Proptosis Regression After Teprotumumab Treatment for Thyroid Eye Disease"., PMID:39240199

Effect of Cannabis Usage on Thyroid Eye Disease., PMID:39197177

Patterns of Teprotumumab-Induced Hearing Dysfunction: A Systematic Review., PMID:39194388

Datasheet

Document Download

Research Grade Teprotumumab.pdf

 

$ 372
Product specifications
100 μg 372 1 mg 1486

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Research Grade Teprotumumab [DHC29903]
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