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Research Grade Enfortumab

Catalog #:   DHJ41001 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ41001

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

LNIR, NECTIN4, PRR4 receptor-related protein 4, Nectin cell adhesion molecule 4, Ig superfamily receptor LNIR, Nectin-4, PVRL4

Concentration

3 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96NY8

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AGS-22CE, AGS-22M, AGS-22M6E, unconjugated : AGS-22C3 or AGSM6, CAS: 1346452-25-2

Clone ID

Enfortumab

Data Image
  • SDS-PAGE
    SDS PAGE for Enfortumab
  • Bioactivity
    Detects NECTIN4/PVRL4 in indirect ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Pivotal Trial of Enfortumab Vedotin in Urothelial Carcinoma After Platinum and Anti-Programmed Death 1/Programmed Death Ligand 1 Therapy, PMID: 31356140

Enfortumab vedotin to treat urothelial carcinoma, PMID: 32406880

Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models, PMID: 27013195

Clinical Overview of Enfortumab Vedotin in the Management of Locally Advanced or Metastatic Urothelial Carcinoma, PMID: 31823332

Enfortumab Vedotin in urothelial cancer, PMID: 33447264

Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma, PMID: 32945172

EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma, PMID: 32031899

Enfortumab Vedotin, a fully human monoclonal antibody against Nectin 4 conjugated to monomethyl auristatin E for metastatic urothelial Carcinoma, PMID: 31526130

A phase I study of enfortumab vedotin in Japanese patients with locally advanced or metastatic urothelial carcinoma, PMID: 31444589

FDA Approval Summary: Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma, PMID: 32962979

Antibodies to watch in 2020, PMID: 31847708

Enfortumab vedotin shows promise in solid tumours, PMID: 32066546

Enfortumab Vedotin Checks Urothelial Cancer, PMID: 31519705

Enfortumab vedotin - next game-changer in urothelial cancer, PMID: 33325754

Flexural Exanthema From Enfortumab Vedotin, PMID: 32542157

The biology and rationale of targeting nectin-4 in urothelial carcinoma, PMID: 33239713

Management of metastatic bladder cancer, PMID: 31030123

Clinicopathologic characterization of enfortumab vedotin-associated cutaneous toxicity in patients with urothelial carcinoma, PMID: 33301805

Enfortumab Vedotin, PMID: 33630480

Emerging Treatment Options for the Treatment of Metastatic Urothelial Cancer: Therapeutic Potential of Enfortumab Vedotin, PMID: 32982431

Antibodies to watch in 2019, PMID: 30516432

The emerging role of antibody-drug conjugates in urothelial carcinoma, PMID: 32552213

Targeting Nectin-4 in Bladder Cancer, PMID: 28634245

A rare presentation of enfortumab vedotin-induced toxic epidermal necrolysis, PMID: 33319007

Antibody-Drug Conjugates in Urothelial Carcinomas, PMID: 32008109

Enfortumab vedotin is safe and effective, PMID: 34031573

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma, PMID: 33577729

Cutaneous toxicity associated with enfortumab vedotin treatment of metastatic urothelial carcinoma, PMID: 30865407

Enfortumab vedotin for cisplatin-ineligible urothelial cancer, PMID: 33991513

Enfortumab Vedotin in Advanced Urothelial Carcinoma, PMID: 34192440

Enfortumab Vedotin in Advanced Urothelial Carcinoma. Reply, PMID: 34192441

Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial, PMID: 33991512

Benefit with enfortumab vedotin confirmed, PMID: 33649567

Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date, PMID: 33603337

Expression of Nectin-4 and PD-L1 in Upper Tract Urothelial Carcinoma, PMID: 32751328

Advancements in Therapy for Bladder Cancer: Enfortumab Vedotin, PMID: 33604101

Targeted Molecular Therapeutics for Bladder Cancer-A New Option beyond the Mixed Fortunes of Immune Checkpoint Inhibitors?, PMID: 33019653

Re: Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma, PMID: 33895011

Severe eczematoid and lichenoid eruption with full-thickness epidermal necrosis developing from metastatic urothelial cancer treated with enfortumab vedotin, PMID: 32860247

Enfortumab Vedotin: Nursing Perspectives on the Management of Adverse Events in Patients With Locally Advanced or Metastatic Urothelial Carcinoma, PMID: 33739346

New and topics: enfortumab vedotin mechanisms of response and resistance in urothelial cancer - What do we understand so far?, PMID: 34148797

Case Report: Enfortumab Vedotin for Metastatic Urothelial Carcinoma: A Case Series on the Clinical and Histopathologic Spectrum of Adverse Cutaneous Reactions From Fatal Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis to Dermal Hypersensitivity Reaction, PMID: 33747934

Current Systemic Treatment Options in Metastatic Urothelial Carcinoma after Progression on Checkpoint Inhibition Therapy-A Systemic Review Combined with Single-Group Meta-Analysis of Three Studies Testing Enfortumab Vedotin, PMID: 34206980

Benefit of nectin-4 targeting with enfortumab vedotin confirmed, PMID: 33692500

Cutaneous reactions with enfortumab vedotin: A case series and review of the literature, PMID: 34235241

Antibody-Drug Conjugates in Bladder Cancer, PMID: 30112436

Emerging biomarkers in urothelial carcinoma: Challenges and opportunities, PMID: 32920502

Antibody-drug conjugates for the treatment of urothelial carcinoma, PMID: 32589063

Updates in the management and future landscape of urothelial carcinoma, PMID: 33143526

The Evolution of Antibody-Drug Conjugates: A Positive Inflexion Point, PMID: 32223669

Enfortumab vedotin therapy complicated by bullous dermatitis: A case report., PMID:40530174

Enfortumab vedotin-induced widespread vesiculobullous eruption mimicking disseminated herpetic infection in a patient with metastatic urothelial carcinoma., PMID:40526955

Optimizing enfortumab vedotin plus pembrolizumab therapy., PMID:40526099

Avelumab maintenance in advanced urothelial carcinoma: real-world data from Northern Spain (AVEBLADDER study)., PMID:40514610

Mechanistic Insights into Anti-Nectin4-VcMMAE-Induced Ocular Toxicity: From Cellular Uptake Pathways to Molecular Modification., PMID:40507807

Enfortumab vedotin induced interstitial lung disease: A first case report with pathological evidence from transbronchial lung cryobiopsy., PMID:40496844

Enfortumab Vedotin-Induced Diabetic Ketoacidosis and Acute Tubulointerstitial Nephritis Requiring Intensive Care in the Treatment of Advanced Urothelial Carcinoma: A Case Report., PMID:40487556

Real-world clinical outcomes of sacituzumab govitecan after prior exposure to enfortumab vedotin in patients with metastatic urothelial carcinoma., PMID:40479863

Two Cases of Enfortumab Vedotin-Induced Drug Eruption Diagnosed Based on the Distinctive Epidermal Mitotic Figures in Patients Receiving Combination Therapy With Pembrolizumab., PMID:40476598

Nectin-4-Targeting Radiotracers: Novel Theranostic Agents for Precision Oncology in Cancer., PMID:40474033

Enfortumab Vedotin Plus Pembrolizumab in Untreated Locally Advanced or Metastatic Urothelial Carcinoma: 2.5-Year Median Follow-Up of the Phase III EV-302/KEYNOTE-A39 Trial., PMID:40460988

Adverse cardiac events associated with antibody drug conjugates in cancer patients: a retrospective analysis on the FAERS database and randomized controlled trials., PMID:40455883

Enfortumab vedotin plus pembrolizumab versus chemotherapy in patients with previously untreated locally advanced or metastatic urothelial cancer (EV-302): patient-reported outcomes from an open-label, randomised, controlled, phase 3 study., PMID:40449498

Antibody-drug conjugates as game changers in bladder cancer: current progress and future directions., PMID:40433388

Consolidative Surgery for Advanced Urothelial Carcinoma Following Induction Enfortumab Vedotin and/or Immune Checkpoint Inhibitor Therapy: A Multicenter Analysis., PMID:40425390

Mechanistic Insights and Future Directions for Enfortumab Vedotin in Urothelial Carcinoma: Highlights from the 10th Annual Leo & Anne Albert Institute for Bladder Cancer Care and Research Symposium., PMID:40422537

E-VIRTUE: a study of enfortumab vedotin with or without pembrolizumab in rare genitourinary tumors-design and rationale., PMID:40421891

Erythema multiforme-like eruption with severe epidermal necrosis after administration of enfortumab vedotin., PMID:40417899

A Case of Generalized Anhidrosis That Developed During Treatment With Enfortumab Vedotin., PMID:40401791

Zelenectide pevedotin (BT-8009): a bicyclic peptide toxin conjugate targeting nectin-4 for the treatment of bladder cancer., PMID:40401457

Progress of antibody-drug conjugates in the treatment of locally advanced or metastatic urothelial carcinoma: opportunities and challenges., PMID:40377724

The patients have spoken: how does enfortumab vedotin impact quality of life?, PMID:40376537

Evaluation of Optimal Sequential Treatment Patterns and Clinical Outcomes in Patients With Advanced Urothelial Carcinoma Treated With First-Line Platinum-Based Chemotherapy: A Multicenter Collaborative Study., PMID:40375459

Immune Checkpoint Inhibitors and Antibody-Drug Conjugates in Urothelial Carcinoma: Current Landscape and Future Directions., PMID:40361519

Increased Risk of Hyperglycemia in Advanced Urothelial Cancer Patients Treated with Enfortumab Vedotin: A Systematic Review and Meta-Analysis., PMID:40358559

Complete Response after Avelumab Maintenance Therapy: Successful Management of Metastatic Urothelial Carcinoma., PMID:40352709

Salvage Surgery Following Remarkable Tumor Shrinkage With Enfortumab Vedotin in Advanced Urothelial Carcinoma., PMID:40336728

Novel Molecular Biomarkers to Guide Treatment Decision-making in Metastatic Urothelial Cancer-A Patient Cohort Analysis., PMID:40300922

Advancements in systemic therapy for muscle-invasive bladder cancer: A systematic review from the beginning to the latest updates., PMID:40296876

Treatment Outcomes After Progression With Enfortumab Vedotin in Patients With Advanced Urothelial Carcinoma., PMID:40295063

Steroid Premedication Impact on Efficacy and Cutaneous Toxicity of Enfortumab Vedotin for Advanced Urothelial Carcinoma., PMID:40295014

Cancer-induced Pain Is Associated With Poor Overall Survival of Urothelial Carcinoma Patients Treated With Enfortumab Vedotin., PMID:40295006

Real-World Clinical Outcomes with First-Line Systemic Treatment and Avelumab Maintenance in US Patients with Locally Advanced or Metastatic Urothelial Carcinoma: The SPEAR Bladder-II Study., PMID:40277744

Evaluation of Nectin-4 and Trop-2: Implications for Patient Outcomes and Therapy in Penile Cancer., PMID:40252843

Association between drug-related cutaneous adverse events and survival outcomes in patients treated with enfortumab vedotin., PMID:40252634

Pembrolizumab after platinum-based chemotherapy for metastatic urothelial cancer: comparison between patients from a Dutch nationwide cohort and KEYNOTE-045., PMID:40250101

Clinical Response to Enfortumab Vedotin and Pembrolizumab in a Patient with Vaginal Squamous Cell Carcinoma: A Case Report., PMID:40235861

Balancing effectiveness, toxicity, and individualization: enfortumab vedotin in advanced urothelial cancer., PMID:40226067

Strategies to overcome resistance to enfortumab vedotin and pembrolizumab for patients with urothelial carcinoma: harnessing present knowledge for future advances., PMID:40225697

Cost-Effectiveness of Enfortumab Vedotin and Pembrolizumab for First-Line Metastatic Urothelial Cancer in the United States., PMID:40220863

High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy., PMID:40215164

Nectin-4 expression patterns and therapeutics in oncology., PMID:40209851

[Enfortumab-vedotin in combination with pembrolizumab as first-line treatment for advanced/metastatic urothelial carcinoma]., PMID:40204543

Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas., PMID:40198857

Organ-specific tumor response to enfortumab vedotin in metastatic urothelial carcinoma: a multicenter retrospective study., PMID:40197493

Editorial Comment to "Impact of Skin Adverse Events on Prognosis in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Treated With Enfortumab Vedotin: A Real-World Multicenter Study"., PMID:40195588

Lines of Therapy for Locally Advanced/Metastatic Urothelial Carcinoma: The New Paradigm., PMID:40184571

Impact of Initial Relative Dose Intensity on Tumor Response and Survival Outcomes in Enfortumab Vedotin Monotherapy for Previously Treated Advanced Urothelial Carcinoma: A Real-world Analysis From a Multicenter Study., PMID:40175211

Oncology: What You May Have Missed in 2024., PMID:40163865

Clinical significance of the dose modification of enfortumab vedotin monotherapy for advanced urothelial carcinoma., PMID:40163660

Datasheet

Document Download

Research Grade Enfortumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Enfortumab [DHJ41001]
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